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DNA copy number changes in Schistosoma-associated and non-Schistosoma-associated bladder cancer.
Am J Pathol. 2000 Mar; 156(3):871-8.AJ

Abstract

DNA copy number changes were investigated in 69 samples of schistosoma-associated (SA) and non-schistosoma-associated (NSA) squamous cell carcinoma (SCC) and transitional cell carcinoma (TCC) of the bladder by comparative genomic hybridization (CGH). DNA copy number changes were detected in 47 tumors. SA tumors had more changes than NSA tumors (mean, 7 vs. 4), whereas the number of changes in SCC and TCC tumors was similar. SA tumors displayed more gains than losses (1.7:1), whereas NSA tumors showed an equal number of gains and losses. Changes that were observed at similar frequencies in SCC and TCC, irrespective of the schistosomal status, included gains and high-level amplifications at 1q, 8q, and 20q and losses in 9p and 13q. These changes may be involved in a common pathway for bladder tumor development and progression independent of schistosomal status or histological subtype. Losses in 3p and gains at 5p were seen only in SCC (P < 0.01) and losses in 5q were more frequent in SA-SCC than in other tumors (P < 0.05). However, changes that were more frequent in TCC than those in SCC included gains at 17q (P < 0.01) and losses in 4q (P < 0.05) and 6q (P < 0.01). Gains and high-level amplifications at 5p were seen only in SA-SCC (P < 0. 01), whereas gains and high-level amplifications with minimal common overlapping regions at 11q13 were more frequently seen both in SA-SCC and SA-TCC tumors (P < 0.01). In addition to the above mentioned alterations, several other changes were also seen at lower frequencies. The variations in the DNA copy number changes observed in TCC, SCC, SA, and NSA bladder carcinomas suggest that these tumors have different genetic pathways.

Authors+Show Affiliations

Department of Medical Genetics, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10702404

Citation

El-Rifai, W, et al. "DNA Copy Number Changes in Schistosoma-associated and non-Schistosoma-associated Bladder Cancer." The American Journal of Pathology, vol. 156, no. 3, 2000, pp. 871-8.
El-Rifai W, Kamel D, Larramendy ML, et al. DNA copy number changes in Schistosoma-associated and non-Schistosoma-associated bladder cancer. Am J Pathol. 2000;156(3):871-8.
El-Rifai, W., Kamel, D., Larramendy, M. L., Shoman, S., Gad, Y., Baithun, S., El-Awady, M., Eissa, S., Khaled, H., Soloneski, S., Sheaff, M., & Knuutila, S. (2000). DNA copy number changes in Schistosoma-associated and non-Schistosoma-associated bladder cancer. The American Journal of Pathology, 156(3), 871-8.
El-Rifai W, et al. DNA Copy Number Changes in Schistosoma-associated and non-Schistosoma-associated Bladder Cancer. Am J Pathol. 2000;156(3):871-8. PubMed PMID: 10702404.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - DNA copy number changes in Schistosoma-associated and non-Schistosoma-associated bladder cancer. AU - El-Rifai,W, AU - Kamel,D, AU - Larramendy,M L, AU - Shoman,S, AU - Gad,Y, AU - Baithun,S, AU - El-Awady,M, AU - Eissa,S, AU - Khaled,H, AU - Soloneski,S, AU - Sheaff,M, AU - Knuutila,S, PY - 2000/3/7/pubmed PY - 2000/3/25/medline PY - 2000/3/7/entrez SP - 871 EP - 8 JF - The American journal of pathology JO - Am. J. Pathol. VL - 156 IS - 3 N2 - DNA copy number changes were investigated in 69 samples of schistosoma-associated (SA) and non-schistosoma-associated (NSA) squamous cell carcinoma (SCC) and transitional cell carcinoma (TCC) of the bladder by comparative genomic hybridization (CGH). DNA copy number changes were detected in 47 tumors. SA tumors had more changes than NSA tumors (mean, 7 vs. 4), whereas the number of changes in SCC and TCC tumors was similar. SA tumors displayed more gains than losses (1.7:1), whereas NSA tumors showed an equal number of gains and losses. Changes that were observed at similar frequencies in SCC and TCC, irrespective of the schistosomal status, included gains and high-level amplifications at 1q, 8q, and 20q and losses in 9p and 13q. These changes may be involved in a common pathway for bladder tumor development and progression independent of schistosomal status or histological subtype. Losses in 3p and gains at 5p were seen only in SCC (P < 0.01) and losses in 5q were more frequent in SA-SCC than in other tumors (P < 0.05). However, changes that were more frequent in TCC than those in SCC included gains at 17q (P < 0.01) and losses in 4q (P < 0.05) and 6q (P < 0.01). Gains and high-level amplifications at 5p were seen only in SA-SCC (P < 0. 01), whereas gains and high-level amplifications with minimal common overlapping regions at 11q13 were more frequently seen both in SA-SCC and SA-TCC tumors (P < 0.01). In addition to the above mentioned alterations, several other changes were also seen at lower frequencies. The variations in the DNA copy number changes observed in TCC, SCC, SA, and NSA bladder carcinomas suggest that these tumors have different genetic pathways. SN - 0002-9440 UR - https://www.unboundmedicine.com/medline/citation/10702404/DNA_copy_number_changes_in_Schistosoma_associated_and_non_Schistosoma_associated_bladder_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9440(10)64956-5 DB - PRIME DP - Unbound Medicine ER -