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Immunomodulation and anti-cancer activity of polysaccharide-protein complexes.
Curr Med Chem. 2000 Jul; 7(7):715-29.CM

Abstract

In the last three decades, numerous polysaccharides and polysaccharide-protein complexes have been isolated from mushrooms and used as a source of therapeutic agents. The most promising biopharmacological activities of these biopolymers are their immunomodulation and anti-cancer effects. They are mainly present as glucans with different types of glycosidic linkages such as (1-->3), (1-->6)-beta-glucans and (1-->3)-alpha-glucans, and as true herteroglycans, while others mostly bind to protein residues as polysaccharide-protein complexes. Three antitumor mushroom polysaccharides, i.e. lentinan, schizophyllan and protein-bound polysaccharide (PSK, Krestin), isolated respectively, from Lentinus edodes, Schizophyllum commune and Coriolus versicolor, have become large market items in Japan. Lentinan and schizophyllan are pure beta-glucans, whereas PSK is a protein-bound beta-glucan. A polysaccharide peptide (PSP), isolated from a strain of Coriolus versicolor in China, has also been widely used as an anti-cancer and immunomodulatory agent. Although the mechansim of their antitumor action is still not completely clear, these polysaccharides and polysaccharide-protein complexes are suggested to enhance cell-mediated immune responses in vivo and in vitro and act as biological response modifiers. Potentiation of the host defense system may result in the activation of many kinds of immune cells that are vitally important for the maintenance of homeostasis. Polysaccharides or polysaccharide-protein complexes are considered as multi-cytokine inducers that are able to induce gene expression of vaious immunomodulatory cytokines and cytokine receptors. Some interesting studies focus on investigation of the relationship between their structure and antitumor activity, elucidation of their antitumor mechanism at the molecular level, and improvement of their various biological activities by chemical modifications.

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Authors+Show Affiliations

Ooi VE
Department of Biology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.
Liu F
No affiliation info available

MeSH

Adjuvants, ImmunologicAnimalsAntineoplastic AgentsHumansIn Vitro TechniquesPolysaccharidesProteins

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10702635

Citation

Ooi, V E., and F Liu. "Immunomodulation and Anti-cancer Activity of Polysaccharide-protein Complexes." Current Medicinal Chemistry, vol. 7, no. 7, 2000, pp. 715-29.
Ooi VE, Liu F. Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Curr Med Chem. 2000;7(7):715-29.
Ooi, V. E., & Liu, F. (2000). Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Current Medicinal Chemistry, 7(7), 715-29.
Ooi VE, Liu F. Immunomodulation and Anti-cancer Activity of Polysaccharide-protein Complexes. Curr Med Chem. 2000;7(7):715-29. PubMed PMID: 10702635.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. AU - Ooi,V E, AU - Liu,F, PY - 2000/3/7/pubmed PY - 2000/7/15/medline PY - 2000/3/7/entrez SP - 715 EP - 29 JF - Current medicinal chemistry JO - Curr Med Chem VL - 7 IS - 7 N2 - In the last three decades, numerous polysaccharides and polysaccharide-protein complexes have been isolated from mushrooms and used as a source of therapeutic agents. The most promising biopharmacological activities of these biopolymers are their immunomodulation and anti-cancer effects. They are mainly present as glucans with different types of glycosidic linkages such as (1-->3), (1-->6)-beta-glucans and (1-->3)-alpha-glucans, and as true herteroglycans, while others mostly bind to protein residues as polysaccharide-protein complexes. Three antitumor mushroom polysaccharides, i.e. lentinan, schizophyllan and protein-bound polysaccharide (PSK, Krestin), isolated respectively, from Lentinus edodes, Schizophyllum commune and Coriolus versicolor, have become large market items in Japan. Lentinan and schizophyllan are pure beta-glucans, whereas PSK is a protein-bound beta-glucan. A polysaccharide peptide (PSP), isolated from a strain of Coriolus versicolor in China, has also been widely used as an anti-cancer and immunomodulatory agent. Although the mechansim of their antitumor action is still not completely clear, these polysaccharides and polysaccharide-protein complexes are suggested to enhance cell-mediated immune responses in vivo and in vitro and act as biological response modifiers. Potentiation of the host defense system may result in the activation of many kinds of immune cells that are vitally important for the maintenance of homeostasis. Polysaccharides or polysaccharide-protein complexes are considered as multi-cytokine inducers that are able to induce gene expression of vaious immunomodulatory cytokines and cytokine receptors. Some interesting studies focus on investigation of the relationship between their structure and antitumor activity, elucidation of their antitumor mechanism at the molecular level, and improvement of their various biological activities by chemical modifications. SN - 0929-8673 UR - https://www.unboundmedicine.com/medline/citation/10702635/Immunomodulation_and_anti_cancer_activity_of_polysaccharide_protein_complexes_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=0929-8673&volume=7&issue=7&spage=715&aulast=Ooi DB - PRIME DP - Unbound Medicine ER -