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[Diabetes mellitus and fibrinogen. Hemorrheological and microcirculatory consequences].
J Mal Vasc. 2000 Feb; 25(1):53-7.JM

Abstract

Fibrinogen level, erythrocyte aggregation and transcutaneous oxygen pressure (TcPO2) were measured in the two populations of 32 healthy volunteer subjects and 119 diabetic patients without any clinical sign of micro and/or macroangiopathy. Measured parameters were studied according to both the long term glycemic control (HbA1C) and the type of diabetes. Results showed a significant elevation of plasma fibrinogen in all diabetic patients even when they had good glycemic control. Hyperfibrinogenemia appeared to be related to both long term glycemic control and type of diabetes. Hyperfibrinogenemia in studied diabetic patients was associated with a tendency to erythrocyte hyperaggregation. Indeed, this hyperaggregation like fibrinogen level, seem to be related to both HbA1C level and the type of diabetes. In contrast, the TcPO2 was found to be significantly decreased in all patients irrespective to either HbA1C or the type of diabetes. Besides, TcPO2 was not correlated with fibrinogen nor erythrocyte aggregation. In conclusion, the decrease in TcPO2 as observed here, does not directly depend upon the type of diabetes, or the HbA1C level, i.e the quality of mid and/or long term glycemic control.

Authors+Show Affiliations

Unité de Recherches d'Hémorhéologie Clinique et de Microcirculation, Nevers, France.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

10705136

Citation

Le Dévéhat, C, et al. "[Diabetes Mellitus and Fibrinogen. Hemorrheological and Microcirculatory Consequences]." Journal Des Maladies Vasculaires, vol. 25, no. 1, 2000, pp. 53-7.
Le Dévéhat C, Khodabandehlou T, Vimeux M. [Diabetes mellitus and fibrinogen. Hemorrheological and microcirculatory consequences]. J Mal Vasc. 2000;25(1):53-7.
Le Dévéhat, C., Khodabandehlou, T., & Vimeux, M. (2000). [Diabetes mellitus and fibrinogen. Hemorrheological and microcirculatory consequences]. Journal Des Maladies Vasculaires, 25(1), 53-7.
Le Dévéhat C, Khodabandehlou T, Vimeux M. [Diabetes Mellitus and Fibrinogen. Hemorrheological and Microcirculatory Consequences]. J Mal Vasc. 2000;25(1):53-7. PubMed PMID: 10705136.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Diabetes mellitus and fibrinogen. Hemorrheological and microcirculatory consequences]. AU - Le Dévéhat,C, AU - Khodabandehlou,T, AU - Vimeux,M, PY - 2000/3/8/pubmed PY - 2000/5/16/medline PY - 2000/3/8/entrez SP - 53 EP - 7 JF - Journal des maladies vasculaires JO - J Mal Vasc VL - 25 IS - 1 N2 - Fibrinogen level, erythrocyte aggregation and transcutaneous oxygen pressure (TcPO2) were measured in the two populations of 32 healthy volunteer subjects and 119 diabetic patients without any clinical sign of micro and/or macroangiopathy. Measured parameters were studied according to both the long term glycemic control (HbA1C) and the type of diabetes. Results showed a significant elevation of plasma fibrinogen in all diabetic patients even when they had good glycemic control. Hyperfibrinogenemia appeared to be related to both long term glycemic control and type of diabetes. Hyperfibrinogenemia in studied diabetic patients was associated with a tendency to erythrocyte hyperaggregation. Indeed, this hyperaggregation like fibrinogen level, seem to be related to both HbA1C level and the type of diabetes. In contrast, the TcPO2 was found to be significantly decreased in all patients irrespective to either HbA1C or the type of diabetes. Besides, TcPO2 was not correlated with fibrinogen nor erythrocyte aggregation. In conclusion, the decrease in TcPO2 as observed here, does not directly depend upon the type of diabetes, or the HbA1C level, i.e the quality of mid and/or long term glycemic control. SN - 0398-0499 UR - https://www.unboundmedicine.com/medline/citation/10705136/[Diabetes_mellitus_and_fibrinogen__Hemorrheological_and_microcirculatory_consequences]_ L2 - http://www.em-consulte.com/retrieve/pii/69429 DB - PRIME DP - Unbound Medicine ER -