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Precursor B-lymphoblastic transformation of grade I follicle center lymphoma.
Am J Clin Pathol. 2000 Mar; 113(3):411-8.AJ

Abstract

Part of the natural history of follicle center lymphoma (FCL) is transformation to a more aggressive neoplasm, almost always a diffuse large B-cell lymphoma. We describe a rare example of a precursor B-lymphoblastic transformation of grade I FCL occurring in a 45-year-old woman 12 years after initial presentation and 3 years after successful treatment for a diffuse large cell transformation. The lymphoblastic lymphoma shared the same immunoglobulin heavy chain gene rearrangement as the FCL as assessed by polymerase chain reaction amplification and direct sequencing, as well as identical kappa light chain gene rearrangements by Southern blot analysis. The immunoglobulin heavy chain variable gene sequences of both tumors showed numerous identical base substitutions compared with germline sequences and 3 additional mutations in the lymphoblastic lymphoma not present in the low-grade FCL. These results indicate origin of the lymphoblastic process from the mature follicle center B-cell clone, rather than divergent origin of the 2 tumors from a common immature B-cell precursor.

Authors+Show Affiliations

Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235-9073, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

10705823

Citation

Kroft, S H., et al. "Precursor B-lymphoblastic Transformation of Grade I Follicle Center Lymphoma." American Journal of Clinical Pathology, vol. 113, no. 3, 2000, pp. 411-8.
Kroft SH, Domiati-Saad R, Finn WG, et al. Precursor B-lymphoblastic transformation of grade I follicle center lymphoma. Am J Clin Pathol. 2000;113(3):411-8.
Kroft, S. H., Domiati-Saad, R., Finn, W. G., Dawson, D. B., Schnitzer, B., Singleton, T. P., & Ross, C. W. (2000). Precursor B-lymphoblastic transformation of grade I follicle center lymphoma. American Journal of Clinical Pathology, 113(3), 411-8.
Kroft SH, et al. Precursor B-lymphoblastic Transformation of Grade I Follicle Center Lymphoma. Am J Clin Pathol. 2000;113(3):411-8. PubMed PMID: 10705823.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Precursor B-lymphoblastic transformation of grade I follicle center lymphoma. AU - Kroft,S H, AU - Domiati-Saad,R, AU - Finn,W G, AU - Dawson,D B, AU - Schnitzer,B, AU - Singleton,T P, AU - Ross,C W, PY - 2000/3/8/pubmed PY - 2000/3/25/medline PY - 2000/3/8/entrez SP - 411 EP - 8 JF - American journal of clinical pathology JO - Am J Clin Pathol VL - 113 IS - 3 N2 - Part of the natural history of follicle center lymphoma (FCL) is transformation to a more aggressive neoplasm, almost always a diffuse large B-cell lymphoma. We describe a rare example of a precursor B-lymphoblastic transformation of grade I FCL occurring in a 45-year-old woman 12 years after initial presentation and 3 years after successful treatment for a diffuse large cell transformation. The lymphoblastic lymphoma shared the same immunoglobulin heavy chain gene rearrangement as the FCL as assessed by polymerase chain reaction amplification and direct sequencing, as well as identical kappa light chain gene rearrangements by Southern blot analysis. The immunoglobulin heavy chain variable gene sequences of both tumors showed numerous identical base substitutions compared with germline sequences and 3 additional mutations in the lymphoblastic lymphoma not present in the low-grade FCL. These results indicate origin of the lymphoblastic process from the mature follicle center B-cell clone, rather than divergent origin of the 2 tumors from a common immature B-cell precursor. SN - 0002-9173 UR - https://www.unboundmedicine.com/medline/citation/10705823/Precursor_B_lymphoblastic_transformation_of_grade_I_follicle_center_lymphoma_ L2 - https://academic.oup.com/ajcp/article-lookup/doi/10.1309/Y2YD-UNA2-C95R-AVM3 DB - PRIME DP - Unbound Medicine ER -