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Associations of tibial lead levels with BsmI polymorphisms in the vitamin D receptor in former organolead manufacturing workers.
Environ Health Perspect. 2000 Mar; 108(3):199-203.EH

Abstract

We evaluated associations of tibial lead levels with polymorphisms in the vitamin D receptor (VDR) in 504 former organolead manufacturing workers with past exposure to lead. In this cross-sectional study, we measured tibial lead by (109)Cd K-shell X-ray fluorescence. Tibial lead was evaluated in subjects with different VDR genotypes defined using the BsmI restriction enzyme, adjusting for confounding variables. Study participants had a mean age +/- SD of 57.4 +/- 7.6 years. A total of 169 (33.5%) subjects were homozygous for the BsmI restriction site (designated bb), 251 (49.8%) were heterozygous (Bb), and 84 (16.7%) were homozygous for the absence of the restriction site (BB). Among all of the study subjects, tibial lead concentrations were low, with a mean +/- SD of 14.4 +/- 9.3 microg Pb/g bone mineral. There were only small differences in tibial lead concentrations by VDR genotype, with mean +/- SD tibial lead concentrations of 13.9 +/- 7.9, 14.3 +/- 9.5, and 15.5 +/- 11.1 in subjects with bb, Bb, and BB, respectively. In a multiple linear regression model of tibial lead concentrations, the VDR genotype modified the relation between age and tibial lead concentrations; subjects with the B allele had larger increases in tibial lead concentrations with increasing age (0.37, 0.48, and 0.67 microg/g per year of age in subjects with bb, Bb, and BB, respectively; the adjusted p-value for trend in slopes = 0.04). The VDR genotype also modified the relation between years since last exposure to lead and tibial lead concentrations. Subjects with bb evidenced an average decline in tibial lead concentrations of 0.10 microg/g per year since their last exposure to lead, whereas subjects with Bb and BB evidenced average increases of 0.03 and 0.11 microg/g per year, respectively (the adjusted p-value for trend in slopes = 0.01). Polymorphisms in the vitamin D receptor modified the relations of age and years since the last exposure to lead with tibial lead concentrations. Although controversy remains on the influence of the VDR genotype on bone mineral density, the data suggest that variant VDR alleles modify lead concentrations in bone, either by influencing lead content or calcium content or both.

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Authors+Show Affiliations

Schwartz BS
Division of Occupational and Environmental Health, Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA. bschwart@jhsph.edu
Stewart WF
No affiliation info available
Kelsey KT
No affiliation info available
Simon D
No affiliation info available
Park S
No affiliation info available
Links JM
No affiliation info available
Todd AC
No affiliation info available

MeSH

AdultAge DistributionAge FactorsAgedBody BurdenBone DensityConfounding Factors, EpidemiologicCross-Sectional StudiesEnvironmental MonitoringGenotypeHumansLeadLinear ModelsMetallurgyMiddle AgedOccupational ExposurePolymorphism, Restriction Fragment LengthRadiographyReceptors, CalcitriolRestriction MappingSpectrometry, X-Ray EmissionTibiaTime FactorsUnited States

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10706524

Citation

Schwartz, B S., et al. "Associations of Tibial Lead Levels With BsmI Polymorphisms in the Vitamin D Receptor in Former Organolead Manufacturing Workers." Environmental Health Perspectives, vol. 108, no. 3, 2000, pp. 199-203.
Schwartz BS, Stewart WF, Kelsey KT, et al. Associations of tibial lead levels with BsmI polymorphisms in the vitamin D receptor in former organolead manufacturing workers. Environ Health Perspect. 2000;108(3):199-203.
Schwartz, B. S., Stewart, W. F., Kelsey, K. T., Simon, D., Park, S., Links, J. M., & Todd, A. C. (2000). Associations of tibial lead levels with BsmI polymorphisms in the vitamin D receptor in former organolead manufacturing workers. Environmental Health Perspectives, 108(3), 199-203.
Schwartz BS, et al. Associations of Tibial Lead Levels With BsmI Polymorphisms in the Vitamin D Receptor in Former Organolead Manufacturing Workers. Environ Health Perspect. 2000;108(3):199-203. PubMed PMID: 10706524.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of tibial lead levels with BsmI polymorphisms in the vitamin D receptor in former organolead manufacturing workers. AU - Schwartz,B S, AU - Stewart,W F, AU - Kelsey,K T, AU - Simon,D, AU - Park,S, AU - Links,J M, AU - Todd,A C, PY - 2000/3/8/pubmed PY - 2000/4/29/medline PY - 2000/3/8/entrez SP - 199 EP - 203 JF - Environmental health perspectives JO - Environ Health Perspect VL - 108 IS - 3 N2 - We evaluated associations of tibial lead levels with polymorphisms in the vitamin D receptor (VDR) in 504 former organolead manufacturing workers with past exposure to lead. In this cross-sectional study, we measured tibial lead by (109)Cd K-shell X-ray fluorescence. Tibial lead was evaluated in subjects with different VDR genotypes defined using the BsmI restriction enzyme, adjusting for confounding variables. Study participants had a mean age +/- SD of 57.4 +/- 7.6 years. A total of 169 (33.5%) subjects were homozygous for the BsmI restriction site (designated bb), 251 (49.8%) were heterozygous (Bb), and 84 (16.7%) were homozygous for the absence of the restriction site (BB). Among all of the study subjects, tibial lead concentrations were low, with a mean +/- SD of 14.4 +/- 9.3 microg Pb/g bone mineral. There were only small differences in tibial lead concentrations by VDR genotype, with mean +/- SD tibial lead concentrations of 13.9 +/- 7.9, 14.3 +/- 9.5, and 15.5 +/- 11.1 in subjects with bb, Bb, and BB, respectively. In a multiple linear regression model of tibial lead concentrations, the VDR genotype modified the relation between age and tibial lead concentrations; subjects with the B allele had larger increases in tibial lead concentrations with increasing age (0.37, 0.48, and 0.67 microg/g per year of age in subjects with bb, Bb, and BB, respectively; the adjusted p-value for trend in slopes = 0.04). The VDR genotype also modified the relation between years since last exposure to lead and tibial lead concentrations. Subjects with bb evidenced an average decline in tibial lead concentrations of 0.10 microg/g per year since their last exposure to lead, whereas subjects with Bb and BB evidenced average increases of 0.03 and 0.11 microg/g per year, respectively (the adjusted p-value for trend in slopes = 0.01). Polymorphisms in the vitamin D receptor modified the relations of age and years since the last exposure to lead with tibial lead concentrations. Although controversy remains on the influence of the VDR genotype on bone mineral density, the data suggest that variant VDR alleles modify lead concentrations in bone, either by influencing lead content or calcium content or both. SN - 0091-6765 UR - https://www.unboundmedicine.com/medline/citation/10706524/Associations_of_tibial_lead_levels_with_BsmI_polymorphisms_in_the_vitamin_D_receptor_in_former_organolead_manufacturing_workers_ L2 - https://ehp.niehs.nih.gov/doi/10.1289/ehp.00108199?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓25 ↑29]

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