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Specific phospholipid fatty acid composition of brain regions in mice. Effects of n-3 polyunsaturated fatty acid deficiency and phospholipid supplementation.
J Lipid Res 2000; 41(3):465-72JL

Abstract

This study examined the effects of dietary alpha-linolenic acid deficiency followed or not by supplementation with phospholipids rich in n;-3 polyunsaturated fatty acid (PUFA) on the fatty acid composition of total phospholipids in 11 brain regions. Three weeks before mating, mice were fed a semisynthetic diet containing both linoleic and alpha-linolenic acid or deficient in alpha-linolenic acid. Pups were fed the same diet as their dams. At the age of 7 weeks, a part of the deficient group were supplemented with n;-3 polyunsaturated fatty acids (PUFA) from either egg yolk or pig brain phospholipids for 2 months. Saturated and monounsaturated fatty acid levels varied among brain regions and were not significantly affected by the diet. In control mice, the level of 22:6 n-3 was significantly higher in the frontal cortex compared to all regions. alpha-Linolenic acid deficiency decreased the level of 22:6 n-3 and was compensated by an increase in 22:5 n-6 in all regions. However, the brain regions were affected differently. After the pituitary gland, the frontal cortex, and the striatum were the most markedly affected with 40% reduction of 22:6 n-3. Supplementation with egg yolk or cerebral phospholipids in deficient mice restored a normal fatty acid composition in brain regions except for the frontal cortex. There was a regional distribution of the fatty acids in the brain and the impact of deficiency in alpha-linolenic acid was region-specific. Dietary egg yolk or cerebral phospholipids are an effective source of n-3 PUFA for the recovery of altered fatty acid composition induced by a diet deficient in n-3 PUFA.

Authors+Show Affiliations

INSERM U26, Unite de Neuro-Pharmaco-Nutrition, 75010 Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10706594

Citation

Carrié, I, et al. "Specific Phospholipid Fatty Acid Composition of Brain Regions in Mice. Effects of N-3 Polyunsaturated Fatty Acid Deficiency and Phospholipid Supplementation." Journal of Lipid Research, vol. 41, no. 3, 2000, pp. 465-72.
Carrié I, Clément M, de Javel D, et al. Specific phospholipid fatty acid composition of brain regions in mice. Effects of n-3 polyunsaturated fatty acid deficiency and phospholipid supplementation. J Lipid Res. 2000;41(3):465-72.
Carrié, I., Clément, M., de Javel, D., Francès, H., & Bourre, J. M. (2000). Specific phospholipid fatty acid composition of brain regions in mice. Effects of n-3 polyunsaturated fatty acid deficiency and phospholipid supplementation. Journal of Lipid Research, 41(3), pp. 465-72.
Carrié I, et al. Specific Phospholipid Fatty Acid Composition of Brain Regions in Mice. Effects of N-3 Polyunsaturated Fatty Acid Deficiency and Phospholipid Supplementation. J Lipid Res. 2000;41(3):465-72. PubMed PMID: 10706594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Specific phospholipid fatty acid composition of brain regions in mice. Effects of n-3 polyunsaturated fatty acid deficiency and phospholipid supplementation. AU - Carrié,I, AU - Clément,M, AU - de Javel,D, AU - Francès,H, AU - Bourre,J M, PY - 2000/3/8/pubmed PY - 2000/5/16/medline PY - 2000/3/8/entrez SP - 465 EP - 72 JF - Journal of lipid research JO - J. Lipid Res. VL - 41 IS - 3 N2 - This study examined the effects of dietary alpha-linolenic acid deficiency followed or not by supplementation with phospholipids rich in n;-3 polyunsaturated fatty acid (PUFA) on the fatty acid composition of total phospholipids in 11 brain regions. Three weeks before mating, mice were fed a semisynthetic diet containing both linoleic and alpha-linolenic acid or deficient in alpha-linolenic acid. Pups were fed the same diet as their dams. At the age of 7 weeks, a part of the deficient group were supplemented with n;-3 polyunsaturated fatty acids (PUFA) from either egg yolk or pig brain phospholipids for 2 months. Saturated and monounsaturated fatty acid levels varied among brain regions and were not significantly affected by the diet. In control mice, the level of 22:6 n-3 was significantly higher in the frontal cortex compared to all regions. alpha-Linolenic acid deficiency decreased the level of 22:6 n-3 and was compensated by an increase in 22:5 n-6 in all regions. However, the brain regions were affected differently. After the pituitary gland, the frontal cortex, and the striatum were the most markedly affected with 40% reduction of 22:6 n-3. Supplementation with egg yolk or cerebral phospholipids in deficient mice restored a normal fatty acid composition in brain regions except for the frontal cortex. There was a regional distribution of the fatty acids in the brain and the impact of deficiency in alpha-linolenic acid was region-specific. Dietary egg yolk or cerebral phospholipids are an effective source of n-3 PUFA for the recovery of altered fatty acid composition induced by a diet deficient in n-3 PUFA. SN - 0022-2275 UR - https://www.unboundmedicine.com/medline/citation/10706594/Specific_phospholipid_fatty_acid_composition_of_brain_regions_in_mice__Effects_of_n_3_polyunsaturated_fatty_acid_deficiency_and_phospholipid_supplementation_ L2 - http://www.jlr.org/cgi/pmidlookup?view=long&pmid=10706594 DB - PRIME DP - Unbound Medicine ER -