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Comparison of topical 0.3% ofloxacin with fortified tobramycin plus cefazolin in the treatment of bacterial keratitis.
Eye (Lond). 1999 Dec; 13 (Pt 6):744-7.E

Abstract

PURPOSE

Ofloxacin is a broad spectrum fluoroquinolone antibiotic with good ocular penetration. We compared ofloxacin 3% solution with a combination of fortified tobramycin sulphate and cefazolin sodium solutions in the treatment of culture-proven bacterial keratitis.

METHODS

Thirty eyes with culture-proven bacterial corneal ulcers were enrolled in a prospective randomised, controlled, double-masked study for comparison. The ofloxacin drop and saline were decanted into two identical-looking bottles to the tobramycin and cefazolin. The cases were randomly allocated into treatment with 0.3% ofloxacin solution or a combination of fortified antibiotics (1.5% tobramycin and 10% cefazolin solutions; control group) along with supportive cycloplegic, vitamins and anti-glaucoma therapy. Student's t-test was used to compare the results.

RESULTS

Staphylococcus aureus and coagulase-negative staphylococci were the two most common organisms isolated. Resolution of the ulcer was achieved in 93% and 87% of cases in the ofloxacin and control groups respectively. The mean time required for symptomatic relief was 7.8 +/- 1.54 days and for epithelial healing 15.0 +/- 3.86 days in ofloxacin group, compared with 8.33 +/- 1.54 days for symptomatic relief and 15.46 +/- 3.86 days for epithelial healing in the control group. Post-resolution best corrected visual acuity of 20/200 or better was achieved in all but one eye in both groups.

CONCLUSIONS

Ofloxacin and combined fortified tobramycin and cefazolin topical drops were comparable for treating cases of bacterial corneal ulcer. However, considering its easy availability and cost-effectiveness, monotherapy with ofloxacin is preferred over the combined fortified tobramycin and cefazolin therapy.

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Authors+Show Affiliations

Panda A
Cornea Service Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. anitap38@hotmail.com
Ahuja R
No affiliation info available
Sastry SS
No affiliation info available

MeSH

AdolescentAdultAgedAnti-Bacterial AgentsAnti-Infective AgentsCefazolinCephalosporinsCorneal UlcerDouble-Blind MethodDrug Therapy, CombinationEye Infections, BacterialFemaleHumansMaleMiddle AgedOfloxacinOphthalmic SolutionsProspective StudiesStaphylococcal InfectionsTobramycinVisual Acuity

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

10707137

Citation

Panda, A, et al. "Comparison of Topical 0.3% Ofloxacin With Fortified Tobramycin Plus Cefazolin in the Treatment of Bacterial Keratitis." Eye (London, England), vol. 13 (Pt 6), 1999, pp. 744-7.
Panda A, Ahuja R, Sastry SS. Comparison of topical 0.3% ofloxacin with fortified tobramycin plus cefazolin in the treatment of bacterial keratitis. Eye (Lond). 1999;13 (Pt 6):744-7.
Panda, A., Ahuja, R., & Sastry, S. S. (1999). Comparison of topical 0.3% ofloxacin with fortified tobramycin plus cefazolin in the treatment of bacterial keratitis. Eye (London, England), 13 (Pt 6), 744-7.
Panda A, Ahuja R, Sastry SS. Comparison of Topical 0.3% Ofloxacin With Fortified Tobramycin Plus Cefazolin in the Treatment of Bacterial Keratitis. Eye (Lond). 1999;13 (Pt 6):744-7. PubMed PMID: 10707137.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of topical 0.3% ofloxacin with fortified tobramycin plus cefazolin in the treatment of bacterial keratitis. AU - Panda,A, AU - Ahuja,R, AU - Sastry,S S, PY - 2000/3/9/pubmed PY - 2000/3/9/medline PY - 2000/3/9/entrez SP - 744 EP - 7 JF - Eye (London, England) JO - Eye (Lond) VL - 13 (Pt 6) N2 - PURPOSE: Ofloxacin is a broad spectrum fluoroquinolone antibiotic with good ocular penetration. We compared ofloxacin 3% solution with a combination of fortified tobramycin sulphate and cefazolin sodium solutions in the treatment of culture-proven bacterial keratitis. METHODS: Thirty eyes with culture-proven bacterial corneal ulcers were enrolled in a prospective randomised, controlled, double-masked study for comparison. The ofloxacin drop and saline were decanted into two identical-looking bottles to the tobramycin and cefazolin. The cases were randomly allocated into treatment with 0.3% ofloxacin solution or a combination of fortified antibiotics (1.5% tobramycin and 10% cefazolin solutions; control group) along with supportive cycloplegic, vitamins and anti-glaucoma therapy. Student's t-test was used to compare the results. RESULTS: Staphylococcus aureus and coagulase-negative staphylococci were the two most common organisms isolated. Resolution of the ulcer was achieved in 93% and 87% of cases in the ofloxacin and control groups respectively. The mean time required for symptomatic relief was 7.8 +/- 1.54 days and for epithelial healing 15.0 +/- 3.86 days in ofloxacin group, compared with 8.33 +/- 1.54 days for symptomatic relief and 15.46 +/- 3.86 days for epithelial healing in the control group. Post-resolution best corrected visual acuity of 20/200 or better was achieved in all but one eye in both groups. CONCLUSIONS: Ofloxacin and combined fortified tobramycin and cefazolin topical drops were comparable for treating cases of bacterial corneal ulcer. However, considering its easy availability and cost-effectiveness, monotherapy with ofloxacin is preferred over the combined fortified tobramycin and cefazolin therapy. SN - 0950-222X UR - https://www.unboundmedicine.com/medline/citation/10707137/Comparison_of_topical_0_3_ofloxacin_with_fortified_tobramycin_plus_cefazolin_in_the_treatment_of_bacterial_keratitis_ L2 - https://doi.org/10.1038/eye.1999.220 DB - PRIME DP - Unbound Medicine ER -