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[The antimutagenic activity of biomass extracts from the cultured cells of medicinal plants in the Ames test].
Tsitol Genet. 1999 Nov-Dec; 33(6):19-25.TG

Abstract

Antimutagenic activity of 20 and 40% ethanol extracts from the biomass of Rhodiola rosea, Polyscias filicifolia, Panax ginseng and Ungernia victoris cultured cells have been studied. DDDTDP, ethidium bromide, benz(a)pyrene, benzidine served as model mutagens for Salmonella typhimurium TA 98 strain (the latter two were tested in presence of metabolic activation system); for S. typhimurium TA 100 strain these were tio-tefa, bichromate potassium and sodium azide and heavy metal compounds (chlorides of manganese, zinc, cadmium, lead acetate) for both strains. Higher capacity of the extracts from the biomass of R. rosea and P. filicifolia to counteract gene mutations induced by various mutagens was demonstrated (ca. 90% inhibition in isolated cases). In the experiment with the metabolic activation most effective proved to be the extracts from the P. ginseng biomass (up to 34% and 47% mutagenicity inhibition).

Authors

Duhan OM
No affiliation info available
Baryliak IR
No affiliation info available
Nester TI
No affiliation info available
Dvornyk AS
No affiliation info available
Kunakh VA
No affiliation info available

MeSH

Antimutagenic AgentsCells, CulturedDose-Response Relationship, DrugMutagenicity TestsMutationPlant ExtractsPlants, MedicinalSalmonella typhimurium

Pub Type(s)

English Abstract
Journal Article

Language

ukr

PubMed ID

10707407

Citation

Duhan, O M., et al. "[The Antimutagenic Activity of Biomass Extracts From the Cultured Cells of Medicinal Plants in the Ames Test]." TSitologiia I Genetika, vol. 33, no. 6, 1999, pp. 19-25.
Duhan OM, Baryliak IR, Nester TI, et al. [The antimutagenic activity of biomass extracts from the cultured cells of medicinal plants in the Ames test]. Tsitol Genet. 1999;33(6):19-25.
Duhan, O. M., Baryliak, I. R., Nester, T. I., Dvornyk, A. S., & Kunakh, V. A. (1999). [The antimutagenic activity of biomass extracts from the cultured cells of medicinal plants in the Ames test]. TSitologiia I Genetika, 33(6), 19-25.
Duhan OM, et al. [The Antimutagenic Activity of Biomass Extracts From the Cultured Cells of Medicinal Plants in the Ames Test]. Tsitol Genet. 1999 Nov-Dec;33(6):19-25. PubMed PMID: 10707407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The antimutagenic activity of biomass extracts from the cultured cells of medicinal plants in the Ames test]. AU - Duhan,O M, AU - Baryliak,I R, AU - Nester,T I, AU - Dvornyk,A S, AU - Kunakh,V A, PY - 2000/3/9/pubmed PY - 2000/3/25/medline PY - 2000/3/9/entrez SP - 19 EP - 25 JF - TSitologiia i genetika JO - Tsitol Genet VL - 33 IS - 6 N2 - Antimutagenic activity of 20 and 40% ethanol extracts from the biomass of Rhodiola rosea, Polyscias filicifolia, Panax ginseng and Ungernia victoris cultured cells have been studied. DDDTDP, ethidium bromide, benz(a)pyrene, benzidine served as model mutagens for Salmonella typhimurium TA 98 strain (the latter two were tested in presence of metabolic activation system); for S. typhimurium TA 100 strain these were tio-tefa, bichromate potassium and sodium azide and heavy metal compounds (chlorides of manganese, zinc, cadmium, lead acetate) for both strains. Higher capacity of the extracts from the biomass of R. rosea and P. filicifolia to counteract gene mutations induced by various mutagens was demonstrated (ca. 90% inhibition in isolated cases). In the experiment with the metabolic activation most effective proved to be the extracts from the P. ginseng biomass (up to 34% and 47% mutagenicity inhibition). SN - 0564-3783 UR - https://www.unboundmedicine.com/medline/citation/10707407/[The_antimutagenic_activity_of_biomass_extracts_from_the_cultured_cells_of_medicinal_plants_in_the_Ames_test]_ DB - PRIME DP - Unbound Medicine ER -