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Increased urinary N-telopeptide cross-linked type 1 collagen predicts bone loss in patients with inflammatory bowel disease.
Am J Gastroenterol. 2000 Mar; 95(3):699-704.AJ

Abstract

OBJECTIVE

Reduced bone mineral density (BMD) is common in patients with inflammatory bowel disease (IBD), but the factors associated with its longitudinal rate of change have not been established. We prospectively assessed the rate of change in BMD, and its association with biochemical markers of bone turnover.

METHODS

Twenty-two patients with Crohn's disease and 14 ulcerative colitis patients age 37.1 +/- 11.6 yr were followed for 2 yr. Lumbar spine (L2-L4) and femoral neck BMD were measured by dual x-ray absorptiometry at baseline and 24 months. Bone-specific alkaline phosphatase, osteocalcin, urinary N-telopeptide crosslinked type 1 collagen (NTx), parathyroid hormone, and 25-hydroxyvitamin-D were determined at baseline.

RESULTS

At baseline, 59% of Crohn's patients and 43% of ulcerative colitis patients were osteoporotic, with spine or femoral neck BMD T-score < -2.5. Spine BMD, and spine and femoral neck T-scores were lower and disease duration was longer in nine patients with ileal resection compared with nonoperated patients (0.84 +/- 0.15 g/cm2 vs 0.96 +/- 0.11 g/cm2, -3.0 +/- 1.5 vs -1.7 +/- 1.3, -3.2 +/- 1.5 vs -2.2 +/- 1.0, respectively; all p < 0.05). At 24 months, 13/36 (36%) and 14/36 (39%) patients experienced spinal and femoral neck bone loss, respectively, with mean annual percent BMD changes of -2.0% and -1.5%, respectively. NTx, a bone resorption marker, inversely correlated with spinal BMD rate of change (r = -0.4, p < 0.05). Using quartiles analysis, patients with the highest NTx (Q4) experienced the greatest decrease in spine BMD compared with patients with the lowest NTx (Q1).

CONCLUSIONS

Spine and femoral neck bone loss continues over time in more than one-third of IBD patients. Increased NTx level predicts spinal bone loss in IBD patients.

Authors+Show Affiliations

Department of Medicine, Hadassah University Hospital on Mount Scopus, Hebrew University Hadassah Medical School, Jerusalem, Israel.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10710060

Citation

Dresner-Pollak, R, et al. "Increased Urinary N-telopeptide Cross-linked Type 1 Collagen Predicts Bone Loss in Patients With Inflammatory Bowel Disease." The American Journal of Gastroenterology, vol. 95, no. 3, 2000, pp. 699-704.
Dresner-Pollak R, Karmeli F, Eliakim R, et al. Increased urinary N-telopeptide cross-linked type 1 collagen predicts bone loss in patients with inflammatory bowel disease. Am J Gastroenterol. 2000;95(3):699-704.
Dresner-Pollak, R., Karmeli, F., Eliakim, R., Ackerman, Z., & Rachmilewitz, D. (2000). Increased urinary N-telopeptide cross-linked type 1 collagen predicts bone loss in patients with inflammatory bowel disease. The American Journal of Gastroenterology, 95(3), 699-704.
Dresner-Pollak R, et al. Increased Urinary N-telopeptide Cross-linked Type 1 Collagen Predicts Bone Loss in Patients With Inflammatory Bowel Disease. Am J Gastroenterol. 2000;95(3):699-704. PubMed PMID: 10710060.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased urinary N-telopeptide cross-linked type 1 collagen predicts bone loss in patients with inflammatory bowel disease. AU - Dresner-Pollak,R, AU - Karmeli,F, AU - Eliakim,R, AU - Ackerman,Z, AU - Rachmilewitz,D, PY - 2000/3/10/pubmed PY - 2000/3/25/medline PY - 2000/3/10/entrez SP - 699 EP - 704 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 95 IS - 3 N2 - OBJECTIVE: Reduced bone mineral density (BMD) is common in patients with inflammatory bowel disease (IBD), but the factors associated with its longitudinal rate of change have not been established. We prospectively assessed the rate of change in BMD, and its association with biochemical markers of bone turnover. METHODS: Twenty-two patients with Crohn's disease and 14 ulcerative colitis patients age 37.1 +/- 11.6 yr were followed for 2 yr. Lumbar spine (L2-L4) and femoral neck BMD were measured by dual x-ray absorptiometry at baseline and 24 months. Bone-specific alkaline phosphatase, osteocalcin, urinary N-telopeptide crosslinked type 1 collagen (NTx), parathyroid hormone, and 25-hydroxyvitamin-D were determined at baseline. RESULTS: At baseline, 59% of Crohn's patients and 43% of ulcerative colitis patients were osteoporotic, with spine or femoral neck BMD T-score < -2.5. Spine BMD, and spine and femoral neck T-scores were lower and disease duration was longer in nine patients with ileal resection compared with nonoperated patients (0.84 +/- 0.15 g/cm2 vs 0.96 +/- 0.11 g/cm2, -3.0 +/- 1.5 vs -1.7 +/- 1.3, -3.2 +/- 1.5 vs -2.2 +/- 1.0, respectively; all p < 0.05). At 24 months, 13/36 (36%) and 14/36 (39%) patients experienced spinal and femoral neck bone loss, respectively, with mean annual percent BMD changes of -2.0% and -1.5%, respectively. NTx, a bone resorption marker, inversely correlated with spinal BMD rate of change (r = -0.4, p < 0.05). Using quartiles analysis, patients with the highest NTx (Q4) experienced the greatest decrease in spine BMD compared with patients with the lowest NTx (Q1). CONCLUSIONS: Spine and femoral neck bone loss continues over time in more than one-third of IBD patients. Increased NTx level predicts spinal bone loss in IBD patients. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/10710060/Increased_urinary_N_telopeptide_cross_linked_type_1_collagen_predicts_bone_loss_in_patients_with_inflammatory_bowel_disease_ L2 - https://Insights.ovid.com/pubmed?pmid=10710060 DB - PRIME DP - Unbound Medicine ER -