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Comparison of endoscopic variceal sclerotherapy alone and in combination with octreotide in controlling acute variceal hemorrhage and early rebleeding in patients with low-risk cirrhosis.
Am J Gastroenterol. 2000 Mar; 95(3):768-71.AJ

Abstract

OBJECTIVE

Efficacy of endoscopic variceal sclerotherapy (EVS) alone and in combination with octreotide in controlling acute variceal bleeding and preventing early rebleeding was compared in a double-blind study.

METHODS

Consecutive patients presenting with variceal bleeding with low-risk liver cirrhosis were randomized into two groups. Group A received EVS with 3-5 ml of ethanolamine oleate per varix and placebo injection at 50 microg/h; group B received the combined therapy of EVS and octreotide 50 microg/h continuously for 5 days. A total of 70 patients (mean age, 38.4 +/- 8.6 yr) were selected for the study, which included 56 men (mean age, 37.9 +/- 8.5 yr) and 14 women (mean age, 40.6 +/- 9.0 yr). Thirty-five patients were allocated in each group.

RESULTS

In group A bleeding was controlled in 30 patients (85.7%) and in group B in 33 (94.3%) (p = 0.24). The number of patients who rebled during the first 5 days after sclerotherapy was eight (22.9%) and two (5.7%) in groups A and B, respectively (p = 0.04). The mean packs of blood transfused to the patients of groups A and B were 2.1 +/- 1.2 packs and 1.5 +/- 0.7 packs, respectively (p = 0.03). The mean hospital stay of group A was 6.6 +/- 1.3 days, whereas that in group B was 5.9 +/- 1.2 days (p = 0.04). One patient from each group died during the course of the study.

CONCLUSIONS

No significant difference was observed in arrest of bleeding in the two groups, but episodes of early rebleeding, blood transfusions, and hospital stay was significantly less in group B.

Authors+Show Affiliations

Chandka Medical College, Larkana, Pakistan.No affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

10710072

Citation

Zuberi, B F., and Q Baloch. "Comparison of Endoscopic Variceal Sclerotherapy Alone and in Combination With Octreotide in Controlling Acute Variceal Hemorrhage and Early Rebleeding in Patients With Low-risk Cirrhosis." The American Journal of Gastroenterology, vol. 95, no. 3, 2000, pp. 768-71.
Zuberi BF, Baloch Q. Comparison of endoscopic variceal sclerotherapy alone and in combination with octreotide in controlling acute variceal hemorrhage and early rebleeding in patients with low-risk cirrhosis. Am J Gastroenterol. 2000;95(3):768-71.
Zuberi, B. F., & Baloch, Q. (2000). Comparison of endoscopic variceal sclerotherapy alone and in combination with octreotide in controlling acute variceal hemorrhage and early rebleeding in patients with low-risk cirrhosis. The American Journal of Gastroenterology, 95(3), 768-71.
Zuberi BF, Baloch Q. Comparison of Endoscopic Variceal Sclerotherapy Alone and in Combination With Octreotide in Controlling Acute Variceal Hemorrhage and Early Rebleeding in Patients With Low-risk Cirrhosis. Am J Gastroenterol. 2000;95(3):768-71. PubMed PMID: 10710072.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of endoscopic variceal sclerotherapy alone and in combination with octreotide in controlling acute variceal hemorrhage and early rebleeding in patients with low-risk cirrhosis. AU - Zuberi,B F, AU - Baloch,Q, PY - 2000/3/10/pubmed PY - 2000/3/25/medline PY - 2000/3/10/entrez SP - 768 EP - 71 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 95 IS - 3 N2 - OBJECTIVE: Efficacy of endoscopic variceal sclerotherapy (EVS) alone and in combination with octreotide in controlling acute variceal bleeding and preventing early rebleeding was compared in a double-blind study. METHODS: Consecutive patients presenting with variceal bleeding with low-risk liver cirrhosis were randomized into two groups. Group A received EVS with 3-5 ml of ethanolamine oleate per varix and placebo injection at 50 microg/h; group B received the combined therapy of EVS and octreotide 50 microg/h continuously for 5 days. A total of 70 patients (mean age, 38.4 +/- 8.6 yr) were selected for the study, which included 56 men (mean age, 37.9 +/- 8.5 yr) and 14 women (mean age, 40.6 +/- 9.0 yr). Thirty-five patients were allocated in each group. RESULTS: In group A bleeding was controlled in 30 patients (85.7%) and in group B in 33 (94.3%) (p = 0.24). The number of patients who rebled during the first 5 days after sclerotherapy was eight (22.9%) and two (5.7%) in groups A and B, respectively (p = 0.04). The mean packs of blood transfused to the patients of groups A and B were 2.1 +/- 1.2 packs and 1.5 +/- 0.7 packs, respectively (p = 0.03). The mean hospital stay of group A was 6.6 +/- 1.3 days, whereas that in group B was 5.9 +/- 1.2 days (p = 0.04). One patient from each group died during the course of the study. CONCLUSIONS: No significant difference was observed in arrest of bleeding in the two groups, but episodes of early rebleeding, blood transfusions, and hospital stay was significantly less in group B. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/10710072/Comparison_of_endoscopic_variceal_sclerotherapy_alone_and_in_combination_with_octreotide_in_controlling_acute_variceal_hemorrhage_and_early_rebleeding_in_patients_with_low_risk_cirrhosis_ L2 - https://Insights.ovid.com/pubmed?pmid=10710072 DB - PRIME DP - Unbound Medicine ER -