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Vegetable and fruit consumption and lung cancer risk in the Netherlands Cohort Study on diet and cancer.

Abstract

OBJECTIVE

The purpose was to study the association between vegetable and fruit consumption and lung cancer incidence using 1074 cases after 6.3 years of follow-up in the Netherlands Cohort Study.

METHODS

Dietary intake was assessed using a 150-item food-frequency questionnaire. Multivariate models were used including age, sex, family history of lung cancer, highest educational level attained, and smoking history.

RESULTS

Statistically significant inverse associations were found with total vegetables and most vegetable groups. Rate ratios (RRs) based on consumption frequency showed the strongest effect of vegetables from the Brassica group (RR 0.5, 95% confidence interval (95% CI) 0.3-0.9, for consumption > or = 3 times per week versus < or = once a month). RR of highest versus lowest quintile of total vegetable consumption was 0.7 (95% CI 0.5-1.0, p-trend 0.001). Statistically significant inverse associations were found for all fruits listed in the questionnaire. RRs for quintiles of total fruit intake were 1.0, 0.7, 0.6, 0.6 and 0.8 respectively (p-trend < 0.0001). Protective effects of fruits and vegetables were stronger in current than in former smokers, and weaker for adenocarcinomas than for other types of tumors.

CONCLUSIONS

Inverse associations with lung cancer are found for both vegetable and fruit intake, but no specific type of vegetable or fruit seems to be particularly responsible.

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  • Authors+Show Affiliations

    ,

    Department of Nutritional Epidemiology, TNO Nutrition and Food Research Institute, Zeist, The Netherlands. Voorrips@voeding.tno.nl

    , , , , ,

    Source

    Cancer causes & control : CCC 11:2 2000 Feb pg 101-15

    MeSH

    Age Distribution
    Aged
    Cohort Studies
    Confidence Intervals
    Confounding Factors (Epidemiology)
    Female
    Fruit
    Humans
    Incidence
    Lung Neoplasms
    Male
    Middle Aged
    Multivariate Analysis
    Netherlands
    Nutrition Surveys
    Prospective Studies
    Risk Assessment
    Sex Distribution
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    10710193

    Citation

    Voorrips, L E., et al. "Vegetable and Fruit Consumption and Lung Cancer Risk in the Netherlands Cohort Study On Diet and Cancer." Cancer Causes & Control : CCC, vol. 11, no. 2, 2000, pp. 101-15.
    Voorrips LE, Goldbohm RA, Verhoeven DT, et al. Vegetable and fruit consumption and lung cancer risk in the Netherlands Cohort Study on diet and cancer. Cancer Causes Control. 2000;11(2):101-15.
    Voorrips, L. E., Goldbohm, R. A., Verhoeven, D. T., van Poppel, G. A., Sturmans, F., Hermus, R. J., & van den Brandt, P. A. (2000). Vegetable and fruit consumption and lung cancer risk in the Netherlands Cohort Study on diet and cancer. Cancer Causes & Control : CCC, 11(2), pp. 101-15.
    Voorrips LE, et al. Vegetable and Fruit Consumption and Lung Cancer Risk in the Netherlands Cohort Study On Diet and Cancer. Cancer Causes Control. 2000;11(2):101-15. PubMed PMID: 10710193.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vegetable and fruit consumption and lung cancer risk in the Netherlands Cohort Study on diet and cancer. AU - Voorrips,L E, AU - Goldbohm,R A, AU - Verhoeven,D T, AU - van Poppel,G A, AU - Sturmans,F, AU - Hermus,R J, AU - van den Brandt,P A, PY - 2000/3/10/pubmed PY - 2000/4/1/medline PY - 2000/3/10/entrez SP - 101 EP - 15 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 11 IS - 2 N2 - OBJECTIVE: The purpose was to study the association between vegetable and fruit consumption and lung cancer incidence using 1074 cases after 6.3 years of follow-up in the Netherlands Cohort Study. METHODS: Dietary intake was assessed using a 150-item food-frequency questionnaire. Multivariate models were used including age, sex, family history of lung cancer, highest educational level attained, and smoking history. RESULTS: Statistically significant inverse associations were found with total vegetables and most vegetable groups. Rate ratios (RRs) based on consumption frequency showed the strongest effect of vegetables from the Brassica group (RR 0.5, 95% confidence interval (95% CI) 0.3-0.9, for consumption > or = 3 times per week versus < or = once a month). RR of highest versus lowest quintile of total vegetable consumption was 0.7 (95% CI 0.5-1.0, p-trend 0.001). Statistically significant inverse associations were found for all fruits listed in the questionnaire. RRs for quintiles of total fruit intake were 1.0, 0.7, 0.6, 0.6 and 0.8 respectively (p-trend < 0.0001). Protective effects of fruits and vegetables were stronger in current than in former smokers, and weaker for adenocarcinomas than for other types of tumors. CONCLUSIONS: Inverse associations with lung cancer are found for both vegetable and fruit intake, but no specific type of vegetable or fruit seems to be particularly responsible. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/10710193/Vegetable_and_fruit_consumption_and_lung_cancer_risk_in_the_Netherlands_Cohort_Study_on_diet_and_cancer_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=10710193.ui DB - PRIME DP - Unbound Medicine ER -