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Relationship between pernicious anaemia and gastric neuroendocrine cell disorders.
Neth J Med. 2000 Feb; 56(2):56-62.NJ

Abstract

The incidence of gastric carcinoid tumours is increasing. This rise is probably due to the number of gastroscopies and improved histological techniques. The majority (65%) of these gastric tumours is associated with chronic atrophic gastritis and pernicious anaemia. In this article two patients are presented, one with pernicious anaemia and gastric neuroendocrine cell hyperplasia and one with pernicious anaemia and multiple gastric carcinoids. These neuroendocrine cell disorders have a relatively favourable prognosis. Therefore, a wait-and-see policy was preferred. The pathogenesis, clinical symptoms, diagnosis, prognosis and treatment of these different neuroendocrine cell manifestations are discussed. We recommend performing a gastroscopy at the time of diagnosis for young patients with pernicious anaemia, and whenever abdominal problems, unexplained weight loss or aggravation of the anaemia arise.

Authors+Show Affiliations

Department of Internal Medicine, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

10710942

Citation

Spoelstra-de Man, A M., et al. "Relationship Between Pernicious Anaemia and Gastric Neuroendocrine Cell Disorders." The Netherlands Journal of Medicine, vol. 56, no. 2, 2000, pp. 56-62.
Spoelstra-de Man AM, Wagenaar SS, van der Sluys Veer A, et al. Relationship between pernicious anaemia and gastric neuroendocrine cell disorders. Neth J Med. 2000;56(2):56-62.
Spoelstra-de Man, A. M., Wagenaar, S. S., van der Sluys Veer, A., & Brouwer, C. B. (2000). Relationship between pernicious anaemia and gastric neuroendocrine cell disorders. The Netherlands Journal of Medicine, 56(2), 56-62.
Spoelstra-de Man AM, et al. Relationship Between Pernicious Anaemia and Gastric Neuroendocrine Cell Disorders. Neth J Med. 2000;56(2):56-62. PubMed PMID: 10710942.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between pernicious anaemia and gastric neuroendocrine cell disorders. AU - Spoelstra-de Man,A M, AU - Wagenaar,S S, AU - van der Sluys Veer,A, AU - Brouwer,C B, PY - 2000/3/11/pubmed PY - 2000/4/15/medline PY - 2000/3/11/entrez SP - 56 EP - 62 JF - The Netherlands journal of medicine JO - Neth J Med VL - 56 IS - 2 N2 - The incidence of gastric carcinoid tumours is increasing. This rise is probably due to the number of gastroscopies and improved histological techniques. The majority (65%) of these gastric tumours is associated with chronic atrophic gastritis and pernicious anaemia. In this article two patients are presented, one with pernicious anaemia and gastric neuroendocrine cell hyperplasia and one with pernicious anaemia and multiple gastric carcinoids. These neuroendocrine cell disorders have a relatively favourable prognosis. Therefore, a wait-and-see policy was preferred. The pathogenesis, clinical symptoms, diagnosis, prognosis and treatment of these different neuroendocrine cell manifestations are discussed. We recommend performing a gastroscopy at the time of diagnosis for young patients with pernicious anaemia, and whenever abdominal problems, unexplained weight loss or aggravation of the anaemia arise. SN - 0300-2977 UR - https://www.unboundmedicine.com/medline/citation/10710942/Relationship_between_pernicious_anaemia_and_gastric_neuroendocrine_cell_disorders_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0300297799001175 DB - PRIME DP - Unbound Medicine ER -