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Bioimpedance resistance ratios for the evaluation of dry weight in hemodialysis.
Clin Nephrol. 2000 Feb; 53(2):108-14.CN

Abstract

MATERIAL

Restoration of body water compartments to normal by ultrafiltration is a major goal of hemodialysis. Dry weight is the term used to define normal body water in dialysis patients, but it is limited, as it is based solely on clinical observations. Bioimpedance spectroscopy can accurately measure the resistance of body fluid compartments. The ratio of the resistances of the intracellular to extracellular water should reflect the relative volume of these compartments. As dialysis patients accumulate excess fluid in their extracellular compartment, this ratio may prove useful in the evaluation of dry weight.

METHODS

We measured the resistances of the intracellular and extracellular fluid compartments in normal subjects to define the normal ratio of the resistances of these compartments. Women had a slightly higher ratio than men (women: 2.41 +/- 0.23 vs. men: 2.08 +/- 0.23 vs. p < 0.0001). The ratios determined in the normal population were taken as the normal physiologic ratio and were used to define physiologic dry weight. We then compared dialysis patients both pre- and post-dialysis to this normal population.

RESULTS

We found that most patients (67%, n = 18) had an elevated ratio pre-dialysis suggesting excess extracellular fluid. Of the 38 treatments in which patients achieved their clinical dry weight, 19 (50%) had persistently elevated Ri/Re ratios, suggesting they had not reached physiologic dry weight.

CONCLUSION

These data suggest that many dialysis patients carry excess extracellular fluid post dialysis despite achieving their clinical dry weight. Furthermore, the resistance ratio derived from bioimpedance spectroscopy may be a useful clinical tool in determining dry weight.

Authors+Show Affiliations

Division of Renal Disease and Hypertension, University of Colorado Health Sciences Center, Denver 80262, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10711412

Citation

Spiegel, D M., et al. "Bioimpedance Resistance Ratios for the Evaluation of Dry Weight in Hemodialysis." Clinical Nephrology, vol. 53, no. 2, 2000, pp. 108-14.
Spiegel DM, Bashir K, Fisch B. Bioimpedance resistance ratios for the evaluation of dry weight in hemodialysis. Clin Nephrol. 2000;53(2):108-14.
Spiegel, D. M., Bashir, K., & Fisch, B. (2000). Bioimpedance resistance ratios for the evaluation of dry weight in hemodialysis. Clinical Nephrology, 53(2), 108-14.
Spiegel DM, Bashir K, Fisch B. Bioimpedance Resistance Ratios for the Evaluation of Dry Weight in Hemodialysis. Clin Nephrol. 2000;53(2):108-14. PubMed PMID: 10711412.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioimpedance resistance ratios for the evaluation of dry weight in hemodialysis. AU - Spiegel,D M, AU - Bashir,K, AU - Fisch,B, PY - 2000/3/11/pubmed PY - 2000/3/25/medline PY - 2000/3/11/entrez SP - 108 EP - 14 JF - Clinical nephrology JO - Clin Nephrol VL - 53 IS - 2 N2 - MATERIAL: Restoration of body water compartments to normal by ultrafiltration is a major goal of hemodialysis. Dry weight is the term used to define normal body water in dialysis patients, but it is limited, as it is based solely on clinical observations. Bioimpedance spectroscopy can accurately measure the resistance of body fluid compartments. The ratio of the resistances of the intracellular to extracellular water should reflect the relative volume of these compartments. As dialysis patients accumulate excess fluid in their extracellular compartment, this ratio may prove useful in the evaluation of dry weight. METHODS: We measured the resistances of the intracellular and extracellular fluid compartments in normal subjects to define the normal ratio of the resistances of these compartments. Women had a slightly higher ratio than men (women: 2.41 +/- 0.23 vs. men: 2.08 +/- 0.23 vs. p < 0.0001). The ratios determined in the normal population were taken as the normal physiologic ratio and were used to define physiologic dry weight. We then compared dialysis patients both pre- and post-dialysis to this normal population. RESULTS: We found that most patients (67%, n = 18) had an elevated ratio pre-dialysis suggesting excess extracellular fluid. Of the 38 treatments in which patients achieved their clinical dry weight, 19 (50%) had persistently elevated Ri/Re ratios, suggesting they had not reached physiologic dry weight. CONCLUSION: These data suggest that many dialysis patients carry excess extracellular fluid post dialysis despite achieving their clinical dry weight. Furthermore, the resistance ratio derived from bioimpedance spectroscopy may be a useful clinical tool in determining dry weight. SN - 0301-0430 UR - https://www.unboundmedicine.com/medline/citation/10711412/Bioimpedance_resistance_ratios_for_the_evaluation_of_dry_weight_in_hemodialysis_ DB - PRIME DP - Unbound Medicine ER -