Tags

Type your tag names separated by a space and hit enter

Diet and cataract: the Blue Mountains Eye Study.
Ophthalmology 2000; 107(3):450-6O

Abstract

PURPOSE

To investigate relationships between a wide range of macro- and micronutrients, including antioxidant vitamins, and the three main types of cataract in older people.

DESIGN

Population-based cross-sectional study.

PARTICIPANTS

Two thousand nine hundred people aged 49 to 97 years living in an urban community near Sydney, Australia.

TESTING

Food frequency questionnaires and lens photography.

MAIN OUTCOME MEASURE

Lens photographs were graded for presence and severity of cortical, nuclear, and posterior subcapsular cataracts.

RESULTS

Higher intakes of protein, vitamin A, niacin, thiamin, and riboflavin were associated with reduced prevalence of nuclear cataract. After adjusting for multiple known cataract risk factors, the odds ratios for those in the highest intake quintile groups compared to those in the lowest intake quintiles were 0.5 (95% confidence interval [CI], 0.3-0.8) for protein, 0.5 (95% CI, 0.3-0.9) for vitamin A, 0.6 (95% CI, 0.4-0.9) for niacin, 0.6 (95% CI, 0.4-0.9) for thiamin, and 0.5 (95% CI, 0.3-0.9) for riboflavin. Intake of polyunsaturated fats was associated with reduced prevalence of cortical cataract. No nutrients were associated with posterior subcapsular cataract.

CONCLUSIONS

The nucleus of the lens is particularly sensitive to nutrient deficiencies. Protein, vitamin A, niacin, thiamin, and riboflavin protected against nuclear cataract in this study.

Authors+Show Affiliations

Department of Public Health and Community Medicine, University of Sydney, Australia. bobc@pub.health.usyd.edu.auNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10711880

Citation

Cumming, R G., et al. "Diet and Cataract: the Blue Mountains Eye Study." Ophthalmology, vol. 107, no. 3, 2000, pp. 450-6.
Cumming RG, Mitchell P, Smith W. Diet and cataract: the Blue Mountains Eye Study. Ophthalmology. 2000;107(3):450-6.
Cumming, R. G., Mitchell, P., & Smith, W. (2000). Diet and cataract: the Blue Mountains Eye Study. Ophthalmology, 107(3), pp. 450-6.
Cumming RG, Mitchell P, Smith W. Diet and Cataract: the Blue Mountains Eye Study. Ophthalmology. 2000;107(3):450-6. PubMed PMID: 10711880.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diet and cataract: the Blue Mountains Eye Study. AU - Cumming,R G, AU - Mitchell,P, AU - Smith,W, PY - 2000/3/11/pubmed PY - 2000/3/18/medline PY - 2000/3/11/entrez SP - 450 EP - 6 JF - Ophthalmology JO - Ophthalmology VL - 107 IS - 3 N2 - PURPOSE: To investigate relationships between a wide range of macro- and micronutrients, including antioxidant vitamins, and the three main types of cataract in older people. DESIGN: Population-based cross-sectional study. PARTICIPANTS: Two thousand nine hundred people aged 49 to 97 years living in an urban community near Sydney, Australia. TESTING: Food frequency questionnaires and lens photography. MAIN OUTCOME MEASURE: Lens photographs were graded for presence and severity of cortical, nuclear, and posterior subcapsular cataracts. RESULTS: Higher intakes of protein, vitamin A, niacin, thiamin, and riboflavin were associated with reduced prevalence of nuclear cataract. After adjusting for multiple known cataract risk factors, the odds ratios for those in the highest intake quintile groups compared to those in the lowest intake quintiles were 0.5 (95% confidence interval [CI], 0.3-0.8) for protein, 0.5 (95% CI, 0.3-0.9) for vitamin A, 0.6 (95% CI, 0.4-0.9) for niacin, 0.6 (95% CI, 0.4-0.9) for thiamin, and 0.5 (95% CI, 0.3-0.9) for riboflavin. Intake of polyunsaturated fats was associated with reduced prevalence of cortical cataract. No nutrients were associated with posterior subcapsular cataract. CONCLUSIONS: The nucleus of the lens is particularly sensitive to nutrient deficiencies. Protein, vitamin A, niacin, thiamin, and riboflavin protected against nuclear cataract in this study. SN - 0161-6420 UR - https://www.unboundmedicine.com/medline/citation/10711880/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(99)00024-X DB - PRIME DP - Unbound Medicine ER -