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Acute generalized exanthematous pustulosis associated with oral terbinafine.
Australas J Dermatol. 2000 Feb; 41(1):42-5.AJ

Abstract

A case history of acute generalized exanthematous pustulosis (AGEP) following oral terbinafine is reported. A 64-year-old woman presented with a rapidly spreading micropustular eruption 3 days after completing a 28-day course of oral terbinafine. There was a positive family history of psoriasis but no personal history. The clinical presentation and histopathology were consistent with AGEP. There was nearly complete resolution of the pustular eruption within 3.5 weeks following cessation of oral terbinafine and treatment with topical and systemic corticosteroids. The patient has remained free of any recurrence 18 months later. A summary of drugs known to be associated with AGEP is presented. Prompt recognition of AGEP is stressed in order to avoid confusion with acute generalized pustular psoriasis or a systemic infection. The most important aspect of management is the immediate withdrawal of the suspect drug.

Authors+Show Affiliations

Hall AP
Department of Dermatology, Western Hospital, Footscray, Victoria, Australia.
Tate B
No affiliation info available

MeSH

Acute DiseaseAdministration, OralAntifungal AgentsBackDrug EruptionsExanthemaFemaleFoot DermatosesHumansMiddle AgedNaphthalenesOnychomycosisTerbinafine

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

10715900

Citation

Hall, A P., and B Tate. "Acute Generalized Exanthematous Pustulosis Associated With Oral Terbinafine." The Australasian Journal of Dermatology, vol. 41, no. 1, 2000, pp. 42-5.
Hall AP, Tate B. Acute generalized exanthematous pustulosis associated with oral terbinafine. Australas J Dermatol. 2000;41(1):42-5.
Hall, A. P., & Tate, B. (2000). Acute generalized exanthematous pustulosis associated with oral terbinafine. The Australasian Journal of Dermatology, 41(1), 42-5.
Hall AP, Tate B. Acute Generalized Exanthematous Pustulosis Associated With Oral Terbinafine. Australas J Dermatol. 2000;41(1):42-5. PubMed PMID: 10715900.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute generalized exanthematous pustulosis associated with oral terbinafine. AU - Hall,A P, AU - Tate,B, PY - 2000/3/15/pubmed PY - 2000/4/1/medline PY - 2000/3/15/entrez SP - 42 EP - 5 JF - The Australasian journal of dermatology JO - Australas J Dermatol VL - 41 IS - 1 N2 - A case history of acute generalized exanthematous pustulosis (AGEP) following oral terbinafine is reported. A 64-year-old woman presented with a rapidly spreading micropustular eruption 3 days after completing a 28-day course of oral terbinafine. There was a positive family history of psoriasis but no personal history. The clinical presentation and histopathology were consistent with AGEP. There was nearly complete resolution of the pustular eruption within 3.5 weeks following cessation of oral terbinafine and treatment with topical and systemic corticosteroids. The patient has remained free of any recurrence 18 months later. A summary of drugs known to be associated with AGEP is presented. Prompt recognition of AGEP is stressed in order to avoid confusion with acute generalized pustular psoriasis or a systemic infection. The most important aspect of management is the immediate withdrawal of the suspect drug. SN - 0004-8380 UR - https://www.unboundmedicine.com/medline/citation/10715900/Acute_generalized_exanthematous_pustulosis_associated_with_oral_terbinafine_ DB - PRIME DP - Unbound Medicine ER -