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Difference in the effect of adiposity on bone density between pre- and postmenopausal women.
Maturitas 2000; 34(3):261-6M

Abstract

OBJECTIVES

Elevated bone mineral density (BMD) in obese women is partially attributable to the higher circulating estrogen levels derived from extraglandular aromatization in adipose tissue. However, it remains unclear whether there is an effect of overall adiposity on BMD in both pre- and postmenopausal women. The difference in the effect of overall adiposity on BMD between pre- and postmenopausal women was investigated.

MATERIALS AND METHODS

Subjects were 296 premenopausal women with regular menstruation and 233 postmenopausal women. Age, age at menarche, years since menopause (YSM, in postmenopausal women), weight, height, and body mass index were recorded. Total fat mass amount, lean mass amount, and percentage of body fat were measured by whole body scanning with dual-energy X-ray absorptiometry (DEXA). Lumbar spine BMD (L2-L4) was measured by DEXA. In each group, significant determinants of BMD were investigated using univariate and stepwise multiple regression analysis.

RESULTS

In postmenopausal women, YSM, lean mass amount, total fat mass amount, and height were significant determinants of BMD (R(2)=0.273, P<0.001). In premenopausal women, only two variables including lean mass amount and age at menarche were significant determinants of lumbar spine BMD (R(2)=0.110, P<0.001), but total fat mass amount and percentage of body fat were not significant determinants of BMD.

CONCLUSION

The effect of overall adiposity on BMD is more prominent in postmenopausal women than in premenopausal women.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10717492

Citation

Douchi, T, et al. "Difference in the Effect of Adiposity On Bone Density Between Pre- and Postmenopausal Women." Maturitas, vol. 34, no. 3, 2000, pp. 261-6.
Douchi T, Yamamoto S, Oki T, et al. Difference in the effect of adiposity on bone density between pre- and postmenopausal women. Maturitas. 2000;34(3):261-6.
Douchi, T., Yamamoto, S., Oki, T., Maruta, K., Kuwahata, R., Yamasaki, H., & Nagata, Y. (2000). Difference in the effect of adiposity on bone density between pre- and postmenopausal women. Maturitas, 34(3), pp. 261-6.
Douchi T, et al. Difference in the Effect of Adiposity On Bone Density Between Pre- and Postmenopausal Women. Maturitas. 2000 Mar 31;34(3):261-6. PubMed PMID: 10717492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Difference in the effect of adiposity on bone density between pre- and postmenopausal women. AU - Douchi,T, AU - Yamamoto,S, AU - Oki,T, AU - Maruta,K, AU - Kuwahata,R, AU - Yamasaki,H, AU - Nagata,Y, PY - 2000/3/16/pubmed PY - 2000/9/19/medline PY - 2000/3/16/entrez SP - 261 EP - 6 JF - Maturitas JO - Maturitas VL - 34 IS - 3 N2 - OBJECTIVES: Elevated bone mineral density (BMD) in obese women is partially attributable to the higher circulating estrogen levels derived from extraglandular aromatization in adipose tissue. However, it remains unclear whether there is an effect of overall adiposity on BMD in both pre- and postmenopausal women. The difference in the effect of overall adiposity on BMD between pre- and postmenopausal women was investigated. MATERIALS AND METHODS: Subjects were 296 premenopausal women with regular menstruation and 233 postmenopausal women. Age, age at menarche, years since menopause (YSM, in postmenopausal women), weight, height, and body mass index were recorded. Total fat mass amount, lean mass amount, and percentage of body fat were measured by whole body scanning with dual-energy X-ray absorptiometry (DEXA). Lumbar spine BMD (L2-L4) was measured by DEXA. In each group, significant determinants of BMD were investigated using univariate and stepwise multiple regression analysis. RESULTS: In postmenopausal women, YSM, lean mass amount, total fat mass amount, and height were significant determinants of BMD (R(2)=0.273, P<0.001). In premenopausal women, only two variables including lean mass amount and age at menarche were significant determinants of lumbar spine BMD (R(2)=0.110, P<0.001), but total fat mass amount and percentage of body fat were not significant determinants of BMD. CONCLUSION: The effect of overall adiposity on BMD is more prominent in postmenopausal women than in premenopausal women. SN - 0378-5122 UR - https://www.unboundmedicine.com/medline/citation/10717492/Difference_in_the_effect_of_adiposity_on_bone_density_between_pre__and_postmenopausal_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378512299001140 DB - PRIME DP - Unbound Medicine ER -