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Effect of low-dose oral contraceptives on androgenic markers and acne.
Contraception. 1999 Nov; 60(5):255-62.C

Abstract

Oral contraceptives (OC) suppress excess androgen production; however, different progestins in combination with low-dose estrogens produce divergent effects on sex hormone-binding globulin (SHBG) and testosterone that may influence clinical outcomes. This multicenter, open-label, randomized study compared biochemical androgen profiles and clinical outcomes associated with two OC containing the same amounts of ethinyl estradiol (EE, 20 micrograms) but different progestins, levonorgestrel (LNG, 100 micrograms), and norethindrone acetate (NETA, 1000 micrograms). Fifty-eight healthy women (18-28 years old) received three cycles of treatment with LNG/EE (n = 30) or NETA/EE (n = 28). The results showed that LNG reduced androgen levels in three compartments--adrenal, ovarian, and peripheral. NETA reduced only adrenal and peripheral androgens. Despite a 2.2-fold greater relative increase in SHBG with NETA than LNG, bioavailable testosterone (T) was reduced by the same amount with LNG and NETA. Both treatments improved acne and were well tolerated. Low-dose OC (EE, 20 micrograms) are effective in reducing circulating androgens and acne lesions without causing weight gain. Although LNG and NETA affected secondary markers differently, both OC formulations produced an equivalent decrease in bioavailable.

Authors+Show Affiliations

University of South Alabama, Mobile, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10717776

Citation

Thorneycroft, I H., et al. "Effect of Low-dose Oral Contraceptives On Androgenic Markers and Acne." Contraception, vol. 60, no. 5, 1999, pp. 255-62.
Thorneycroft IH, Stanczyk FZ, Bradshaw KD, et al. Effect of low-dose oral contraceptives on androgenic markers and acne. Contraception. 1999;60(5):255-62.
Thorneycroft, I. H., Stanczyk, F. Z., Bradshaw, K. D., Ballagh, S. A., Nichols, M., & Weber, M. E. (1999). Effect of low-dose oral contraceptives on androgenic markers and acne. Contraception, 60(5), 255-62.
Thorneycroft IH, et al. Effect of Low-dose Oral Contraceptives On Androgenic Markers and Acne. Contraception. 1999;60(5):255-62. PubMed PMID: 10717776.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of low-dose oral contraceptives on androgenic markers and acne. AU - Thorneycroft,I H, AU - Stanczyk,F Z, AU - Bradshaw,K D, AU - Ballagh,S A, AU - Nichols,M, AU - Weber,M E, PY - 2000/3/16/pubmed PY - 2000/3/16/medline PY - 2000/3/16/entrez KW - Acne KW - Americas KW - Androgens KW - Biology KW - California KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Female KW - Contraceptive Agents, Progestin KW - Contraceptive Methods KW - Dermatitis KW - Developed Countries KW - Diseases KW - Endocrine System KW - Family Planning KW - Hormones KW - Levonorgestrel KW - Norethindrone KW - Norethindrone Acetate KW - North America KW - Northern America KW - Oral Contraceptives KW - Physiology KW - Research Report KW - Testosterone KW - United States SP - 255 EP - 62 JF - Contraception JO - Contraception VL - 60 IS - 5 N2 - Oral contraceptives (OC) suppress excess androgen production; however, different progestins in combination with low-dose estrogens produce divergent effects on sex hormone-binding globulin (SHBG) and testosterone that may influence clinical outcomes. This multicenter, open-label, randomized study compared biochemical androgen profiles and clinical outcomes associated with two OC containing the same amounts of ethinyl estradiol (EE, 20 micrograms) but different progestins, levonorgestrel (LNG, 100 micrograms), and norethindrone acetate (NETA, 1000 micrograms). Fifty-eight healthy women (18-28 years old) received three cycles of treatment with LNG/EE (n = 30) or NETA/EE (n = 28). The results showed that LNG reduced androgen levels in three compartments--adrenal, ovarian, and peripheral. NETA reduced only adrenal and peripheral androgens. Despite a 2.2-fold greater relative increase in SHBG with NETA than LNG, bioavailable testosterone (T) was reduced by the same amount with LNG and NETA. Both treatments improved acne and were well tolerated. Low-dose OC (EE, 20 micrograms) are effective in reducing circulating androgens and acne lesions without causing weight gain. Although LNG and NETA affected secondary markers differently, both OC formulations produced an equivalent decrease in bioavailable. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/10717776/Effect_of_low_dose_oral_contraceptives_on_androgenic_markers_and_acne_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0010-7824(99)00093-1 DB - PRIME DP - Unbound Medicine ER -