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RETRACTED ARTICLE

Randomized clinical trial of granisetron, droperidol and metoclopramide for the treatment of nausea and vomiting after laparoscopic cholecystectomy.
Br J Surg. 2000 Mar; 87(3):285-8.BJ

Abstract

BACKGROUND

Patients undergoing laparoscopic cholecystectomy (LC) may be especially at risk of experiencing postoperative nausea and vomiting (PONV). This study was undertaken to evaluate the efficacy of granisetron, droperidol and metoclopramide for the treatment of PONV after LC.

METHODS

After experiencing PONV during the first 3 h after recovery from anaesthesia, 120 patients (78 women) received, in a randomized double-blind manner, granisetron 40 microg/kg, droperidol 20 microg/kg or metoclopramide 0.2 mg/kg (n = 40 per group) intravenously. Patients were then observed for 24 h after administration of the study drug.

RESULTS

Complete control of established PONV, defined as no emetic symptoms and no need for another rescue antiemetic medication, was achieved in 88 per cent of patients with granisetron, 60 per cent with droperidol and 55 per cent with metoclopramide (P < 0.05). No clinically adverse events were observed in any of the groups.

CONCLUSION

A high dose of granisetron (40 microg/kg) was more effective than droperidol 20 microg/kg or metoclopramide 0.2 mg/kg for the treatment of established PONV after LC.

Authors+Show Affiliations

Departments of Anaesthesiology and Surgery, Toride Kyodo General Hospital, Toride City, Ibaraki, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Retracted Publication

Language

eng

PubMed ID

10718795

Citation

Fujii, Y, et al. "Randomized Clinical Trial of Granisetron, Droperidol and Metoclopramide for the Treatment of Nausea and Vomiting After Laparoscopic Cholecystectomy." The British Journal of Surgery, vol. 87, no. 3, 2000, pp. 285-8.
Fujii Y, Tanaka H, Kawasaki T. Randomized clinical trial of granisetron, droperidol and metoclopramide for the treatment of nausea and vomiting after laparoscopic cholecystectomy. Br J Surg. 2000;87(3):285-8.
Fujii, Y., Tanaka, H., & Kawasaki, T. (2000). Randomized clinical trial of granisetron, droperidol and metoclopramide for the treatment of nausea and vomiting after laparoscopic cholecystectomy. The British Journal of Surgery, 87(3), 285-8.
Fujii Y, Tanaka H, Kawasaki T. Randomized Clinical Trial of Granisetron, Droperidol and Metoclopramide for the Treatment of Nausea and Vomiting After Laparoscopic Cholecystectomy. Br J Surg. 2000;87(3):285-8. PubMed PMID: 10718795.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Randomized clinical trial of granisetron, droperidol and metoclopramide for the treatment of nausea and vomiting after laparoscopic cholecystectomy. AU - Fujii,Y, AU - Tanaka,H, AU - Kawasaki,T, PY - 2000/3/16/pubmed PY - 2000/3/16/medline PY - 2000/3/16/entrez SP - 285 EP - 8 JF - The British journal of surgery JO - Br J Surg VL - 87 IS - 3 N2 - BACKGROUND: Patients undergoing laparoscopic cholecystectomy (LC) may be especially at risk of experiencing postoperative nausea and vomiting (PONV). This study was undertaken to evaluate the efficacy of granisetron, droperidol and metoclopramide for the treatment of PONV after LC. METHODS: After experiencing PONV during the first 3 h after recovery from anaesthesia, 120 patients (78 women) received, in a randomized double-blind manner, granisetron 40 microg/kg, droperidol 20 microg/kg or metoclopramide 0.2 mg/kg (n = 40 per group) intravenously. Patients were then observed for 24 h after administration of the study drug. RESULTS: Complete control of established PONV, defined as no emetic symptoms and no need for another rescue antiemetic medication, was achieved in 88 per cent of patients with granisetron, 60 per cent with droperidol and 55 per cent with metoclopramide (P < 0.05). No clinically adverse events were observed in any of the groups. CONCLUSION: A high dose of granisetron (40 microg/kg) was more effective than droperidol 20 microg/kg or metoclopramide 0.2 mg/kg for the treatment of established PONV after LC. SN - 0007-1323 UR - https://www.unboundmedicine.com/medline/citation/10718795/Randomized_clinical_trial_of_granisetron_droperidol_and_metoclopramide_for_the_treatment_of_nausea_and_vomiting_after_laparoscopic_cholecystectomy_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0007-1323&amp;date=2000&amp;volume=87&amp;issue=3&amp;spage=285 DB - PRIME DP - Unbound Medicine ER -