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The contribution of genetic influences to measures of lower-extremity function in older male twins.
J Gerontol A Biol Sci Med Sci 2000; 55(1):B49-53JG

Abstract

Tests of balance, gait, and endurance were administered to 95 monozygotic (MZ) and 92 dizygotic (DZ), white male twins aged 68 to 79 years who had been born in the United States. Within-twin-pair correlations were calculated for each individual task and for an overall summary performance score. These were subjected to structural equation modeling to determine the contributions of genetic and environmental influences to individual differences in performance scores. MZ intraclass correlations were significant and greater than DZ correlations for the 8-foot walk and the repeated chair stands task, but not for the standing balance task. The heritability of the lower-extremity summary score was 57%, of which 39% was due to additive genetic effects and 18% due to nonadditive effects. In addition, we found that genetic influences contributed primarily to twin similarity in the poorest quartile of performance, whereas shared environmental influences contributed to twin similarity in the best quartile.

Authors+Show Affiliations

Center for Health Sciences, SRI International, Menlo Park, California 94025, USA. doritc@unix.sri.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Twin Study

Language

eng

PubMed ID

10719763

Citation

Carmelli, D, et al. "The Contribution of Genetic Influences to Measures of Lower-extremity Function in Older Male Twins." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 55, no. 1, 2000, pp. B49-53.
Carmelli D, Kelly-Hayes M, Wolf PA, et al. The contribution of genetic influences to measures of lower-extremity function in older male twins. J Gerontol A Biol Sci Med Sci. 2000;55(1):B49-53.
Carmelli, D., Kelly-Hayes, M., Wolf, P. A., Swan, G. E., Jack, L. M., Reed, T., & Guralnik, J. M. (2000). The contribution of genetic influences to measures of lower-extremity function in older male twins. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 55(1), pp. B49-53.
Carmelli D, et al. The Contribution of Genetic Influences to Measures of Lower-extremity Function in Older Male Twins. J Gerontol A Biol Sci Med Sci. 2000;55(1):B49-53. PubMed PMID: 10719763.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The contribution of genetic influences to measures of lower-extremity function in older male twins. AU - Carmelli,D, AU - Kelly-Hayes,M, AU - Wolf,P A, AU - Swan,G E, AU - Jack,L M, AU - Reed,T, AU - Guralnik,J M, PY - 2000/3/17/pubmed PY - 2000/4/1/medline PY - 2000/3/17/entrez SP - B49 EP - 53 JF - The journals of gerontology. Series A, Biological sciences and medical sciences JO - J. Gerontol. A Biol. Sci. Med. Sci. VL - 55 IS - 1 N2 - Tests of balance, gait, and endurance were administered to 95 monozygotic (MZ) and 92 dizygotic (DZ), white male twins aged 68 to 79 years who had been born in the United States. Within-twin-pair correlations were calculated for each individual task and for an overall summary performance score. These were subjected to structural equation modeling to determine the contributions of genetic and environmental influences to individual differences in performance scores. MZ intraclass correlations were significant and greater than DZ correlations for the 8-foot walk and the repeated chair stands task, but not for the standing balance task. The heritability of the lower-extremity summary score was 57%, of which 39% was due to additive genetic effects and 18% due to nonadditive effects. In addition, we found that genetic influences contributed primarily to twin similarity in the poorest quartile of performance, whereas shared environmental influences contributed to twin similarity in the best quartile. SN - 1079-5006 UR - https://www.unboundmedicine.com/medline/citation/10719763/The_contribution_of_genetic_influences_to_measures_of_lower_extremity_function_in_older_male_twins_ L2 - https://academic.oup.com/biomedgerontology/article-lookup/doi/10.1093/gerona/55.1.b49 DB - PRIME DP - Unbound Medicine ER -