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Correlation between pertussis toxin IgG antibodies in postvaccination sera and subsequent protection against pertussis.
J Infect Dis. 2000 Mar; 181(3):1010-3.JI

Abstract

All acellular pertussis vaccines contain pertussis toxoid and induce protection against pertussis. This study investigated the relation between the postvaccination levels of pertussis toxin (PT) serum IgG and protection against pertussis. PT IgG was determined in sera obtained 21-77 days after the third vaccination from 813 children who received 3 doses of pertussis toxoid. The children were followed for 21-33 months after vaccination for the occurrence of pertussis. Of the children, 126 were exposed to pertussis in their households. The median PT IgG concentration was 79 U/mL in those who developed severe pertussis (>/=21 day of paroxysmal cough), 156 U/mL with mild pertussis (<21 days of paroxysmal cough), and 246 U/mL in those who did not develop pertussis (79 vs. 246, P<.0001). Corresponding values in the 687 children with no household exposure were 99, 124, and 155 U/mL, respectively (99 vs. 155, P<.0001). Thus, there is a highly significant correlation between the level of vaccine-induced serum PT IgG and protection against pertussis.

Authors+Show Affiliations

Göteborg Pertussis Vaccine Study, Göteborg Primary Health Care System, S-416 60 Göteborg, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10720524

Citation

Taranger, J, et al. "Correlation Between Pertussis Toxin IgG Antibodies in Postvaccination Sera and Subsequent Protection Against Pertussis." The Journal of Infectious Diseases, vol. 181, no. 3, 2000, pp. 1010-3.
Taranger J, Trollfors B, Lagergård T, et al. Correlation between pertussis toxin IgG antibodies in postvaccination sera and subsequent protection against pertussis. J Infect Dis. 2000;181(3):1010-3.
Taranger, J., Trollfors, B., Lagergård, T., Sundh, V., Bryla, D. A., Schneerson, R., & Robbins, J. B. (2000). Correlation between pertussis toxin IgG antibodies in postvaccination sera and subsequent protection against pertussis. The Journal of Infectious Diseases, 181(3), 1010-3.
Taranger J, et al. Correlation Between Pertussis Toxin IgG Antibodies in Postvaccination Sera and Subsequent Protection Against Pertussis. J Infect Dis. 2000;181(3):1010-3. PubMed PMID: 10720524.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation between pertussis toxin IgG antibodies in postvaccination sera and subsequent protection against pertussis. AU - Taranger,J, AU - Trollfors,B, AU - Lagergård,T, AU - Sundh,V, AU - Bryla,D A, AU - Schneerson,R, AU - Robbins,J B, PY - 2000/3/18/pubmed PY - 2000/4/29/medline PY - 2000/3/18/entrez SP - 1010 EP - 3 JF - The Journal of infectious diseases JO - J Infect Dis VL - 181 IS - 3 N2 - All acellular pertussis vaccines contain pertussis toxoid and induce protection against pertussis. This study investigated the relation between the postvaccination levels of pertussis toxin (PT) serum IgG and protection against pertussis. PT IgG was determined in sera obtained 21-77 days after the third vaccination from 813 children who received 3 doses of pertussis toxoid. The children were followed for 21-33 months after vaccination for the occurrence of pertussis. Of the children, 126 were exposed to pertussis in their households. The median PT IgG concentration was 79 U/mL in those who developed severe pertussis (>/=21 day of paroxysmal cough), 156 U/mL with mild pertussis (<21 days of paroxysmal cough), and 246 U/mL in those who did not develop pertussis (79 vs. 246, P<.0001). Corresponding values in the 687 children with no household exposure were 99, 124, and 155 U/mL, respectively (99 vs. 155, P<.0001). Thus, there is a highly significant correlation between the level of vaccine-induced serum PT IgG and protection against pertussis. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/10720524/Correlation_between_pertussis_toxin_IgG_antibodies_in_postvaccination_sera_and_subsequent_protection_against_pertussis_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/315318 DB - PRIME DP - Unbound Medicine ER -