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Role of histamine H(1) receptor in pain perception: a study of the receptor gene knockout mice.
Eur J Pharmacol. 2000 Mar 10; 391(1-2):81-9.EJ

Abstract

To study the participation of histamine H(1) receptors in pain perception, histamine H(1) receptor knockout mice were examined for pain threshold by means of three different kinds of nociceptive tasks. These included assays for thermal nociception (hot-plate, tail-flick, paw-withdrawal), mechanical nociception (tail-pressure), and chemical nociception (abdominal constriction, formalin test, capsaicin test) which evoked pain by the activation in nociceptive Adelta and C fibers. The mutant mice lacking histamine H(1) receptors showed significantly fewer nociceptive responses to the hot-plate, tail-flick, tail-pressure, paw-withdrawal, formalin, capsaicin, and abdominal constriction tests. Sensitivity to noxious stimuli in histamine H(1) receptor knockout mice significantly decreased when compared to wild-type mice. This data indicates that histamine plays an important role in both somatic and visceral pain perceptions through histamine H(1) receptors. The difference in the effect of histamine H(1) receptors antagonist, the active (D-) and inactive (L-) isomers of chlorpheniramine on ICR mice further substantiates the evidence of the role of histamine H(1) receptors on pain threshold.

Authors+Show Affiliations

Department of Pharmacology, Tohoku University School of Medicine, Seiryo-machi 2-1, Aoba-Ku, Sendai, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10720638

Citation

Mobarakeh, J I., et al. "Role of Histamine H(1) Receptor in Pain Perception: a Study of the Receptor Gene Knockout Mice." European Journal of Pharmacology, vol. 391, no. 1-2, 2000, pp. 81-9.
Mobarakeh JI, Sakurada S, Katsuyama S, et al. Role of histamine H(1) receptor in pain perception: a study of the receptor gene knockout mice. Eur J Pharmacol. 2000;391(1-2):81-9.
Mobarakeh, J. I., Sakurada, S., Katsuyama, S., Kutsuwa, M., Kuramasu, A., Lin, Z. Y., Watanabe, T., Hashimoto, Y., Watanabe, T., & Yanai, K. (2000). Role of histamine H(1) receptor in pain perception: a study of the receptor gene knockout mice. European Journal of Pharmacology, 391(1-2), 81-9.
Mobarakeh JI, et al. Role of Histamine H(1) Receptor in Pain Perception: a Study of the Receptor Gene Knockout Mice. Eur J Pharmacol. 2000 Mar 10;391(1-2):81-9. PubMed PMID: 10720638.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of histamine H(1) receptor in pain perception: a study of the receptor gene knockout mice. AU - Mobarakeh,J I, AU - Sakurada,S, AU - Katsuyama,S, AU - Kutsuwa,M, AU - Kuramasu,A, AU - Lin,Z Y, AU - Watanabe,T, AU - Hashimoto,Y, AU - Watanabe,T, AU - Yanai,K, PY - 2000/3/18/pubmed PY - 2000/5/16/medline PY - 2000/3/18/entrez SP - 81 EP - 9 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 391 IS - 1-2 N2 - To study the participation of histamine H(1) receptors in pain perception, histamine H(1) receptor knockout mice were examined for pain threshold by means of three different kinds of nociceptive tasks. These included assays for thermal nociception (hot-plate, tail-flick, paw-withdrawal), mechanical nociception (tail-pressure), and chemical nociception (abdominal constriction, formalin test, capsaicin test) which evoked pain by the activation in nociceptive Adelta and C fibers. The mutant mice lacking histamine H(1) receptors showed significantly fewer nociceptive responses to the hot-plate, tail-flick, tail-pressure, paw-withdrawal, formalin, capsaicin, and abdominal constriction tests. Sensitivity to noxious stimuli in histamine H(1) receptor knockout mice significantly decreased when compared to wild-type mice. This data indicates that histamine plays an important role in both somatic and visceral pain perceptions through histamine H(1) receptors. The difference in the effect of histamine H(1) receptors antagonist, the active (D-) and inactive (L-) isomers of chlorpheniramine on ICR mice further substantiates the evidence of the role of histamine H(1) receptors on pain threshold. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/10720638/Role_of_histamine_H_1__receptor_in_pain_perception:_a_study_of_the_receptor_gene_knockout_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(00)00060-1 DB - PRIME DP - Unbound Medicine ER -