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Triptans. A support to the central link between serotonin and acetylcholine in migraine.
Adv Exp Med Biol 1999; 467:183-9AE

Abstract

Recently synthesized triptans, sumatriptan derivatives, display aborting migraine activity at doses and with plasmatic maximum peak dramatically lower (20-40 times) than sumatriptan, the 5-HT like agonist, which is the original molecule. That triptans easily cross blood-brain barrier strongly supports the central theory of migraine. We recently discovered the anti-migraine prophylactic action of centrally acting anti-cholinesterase agents, that seems a further support to the central theory of migraine. Indeed, acetylcholine is an important analgesia neurotransmitter and is intertwined with 5-HT central pathways.

Authors+Show Affiliations

Interuniversity Centre of Neurochemistry, Florence, Italy.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10721055

Citation

Nicolodi, M, and F Sicuteri. "Triptans. a Support to the Central Link Between Serotonin and Acetylcholine in Migraine." Advances in Experimental Medicine and Biology, vol. 467, 1999, pp. 183-9.
Nicolodi M, Sicuteri F. Triptans. A support to the central link between serotonin and acetylcholine in migraine. Adv Exp Med Biol. 1999;467:183-9.
Nicolodi, M., & Sicuteri, F. (1999). Triptans. A support to the central link between serotonin and acetylcholine in migraine. Advances in Experimental Medicine and Biology, 467, pp. 183-9.
Nicolodi M, Sicuteri F. Triptans. a Support to the Central Link Between Serotonin and Acetylcholine in Migraine. Adv Exp Med Biol. 1999;467:183-9. PubMed PMID: 10721055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Triptans. A support to the central link between serotonin and acetylcholine in migraine. AU - Nicolodi,M, AU - Sicuteri,F, PY - 2000/3/18/pubmed PY - 2000/5/16/medline PY - 2000/3/18/entrez SP - 183 EP - 9 JF - Advances in experimental medicine and biology JO - Adv. Exp. Med. Biol. VL - 467 N2 - Recently synthesized triptans, sumatriptan derivatives, display aborting migraine activity at doses and with plasmatic maximum peak dramatically lower (20-40 times) than sumatriptan, the 5-HT like agonist, which is the original molecule. That triptans easily cross blood-brain barrier strongly supports the central theory of migraine. We recently discovered the anti-migraine prophylactic action of centrally acting anti-cholinesterase agents, that seems a further support to the central theory of migraine. Indeed, acetylcholine is an important analgesia neurotransmitter and is intertwined with 5-HT central pathways. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/10721055/Triptans__A_support_to_the_central_link_between_serotonin_and_acetylcholine_in_migraine_ L2 - http://www.diseaseinfosearch.org/result/4811 DB - PRIME DP - Unbound Medicine ER -