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Prolonged effect of liposomes encapsulating pilocarpine HCl in normal and glaucomatous rabbits.
Int J Pharm. 2000 Mar 30; 198(1):29-38.IJ

Abstract

The possibility of using liposomes as an ophthalmic drug delivery carrier for the lipophilic drug, pilocarpine HCl, was investigated on the eyes of normal and glaucomatous pigmented rabbits. The intraocular pressure (IOP) of rabbits was measured, using a Shi∅tz tonometer, as a function of time after topical administration with free drug, neutral and negatively charged multilamellar vesicles (MLVs) encapsulating pilocarpine HCl. The results showed that administration with neutral MLVs displayed the most prolonged effect with respect to negatively charged MLVs and free drug. The efficiency of MLVs encapsulating pilocarpine HCl, measured using spectrophotometric technique, was found to be 96% in our modified preparations. The storage stability of MLVs encapsulating pilocarpine HCl was investigated by measuring phase transition and size distribution using light scattering technique. The results show that liposomes encapsulating pilocarpine HCl have kept their integrity and physicochemical properties for at least 15 months, which makes them suitable for commercial use.

Authors+Show Affiliations

Biophysics Department, Faculty of Science, Cairo University, Cairo, Egypt.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10722948

Citation

Monem, A S., et al. "Prolonged Effect of Liposomes Encapsulating Pilocarpine HCl in Normal and Glaucomatous Rabbits." International Journal of Pharmaceutics, vol. 198, no. 1, 2000, pp. 29-38.
Monem AS, Ali FM, Ismail MW. Prolonged effect of liposomes encapsulating pilocarpine HCl in normal and glaucomatous rabbits. Int J Pharm. 2000;198(1):29-38.
Monem, A. S., Ali, F. M., & Ismail, M. W. (2000). Prolonged effect of liposomes encapsulating pilocarpine HCl in normal and glaucomatous rabbits. International Journal of Pharmaceutics, 198(1), 29-38.
Monem AS, Ali FM, Ismail MW. Prolonged Effect of Liposomes Encapsulating Pilocarpine HCl in Normal and Glaucomatous Rabbits. Int J Pharm. 2000 Mar 30;198(1):29-38. PubMed PMID: 10722948.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prolonged effect of liposomes encapsulating pilocarpine HCl in normal and glaucomatous rabbits. AU - Monem,A S, AU - Ali,F M, AU - Ismail,M W, PY - 2000/3/21/pubmed PY - 2000/6/8/medline PY - 2000/3/21/entrez SP - 29 EP - 38 JF - International journal of pharmaceutics JO - Int J Pharm VL - 198 IS - 1 N2 - The possibility of using liposomes as an ophthalmic drug delivery carrier for the lipophilic drug, pilocarpine HCl, was investigated on the eyes of normal and glaucomatous pigmented rabbits. The intraocular pressure (IOP) of rabbits was measured, using a Shi∅tz tonometer, as a function of time after topical administration with free drug, neutral and negatively charged multilamellar vesicles (MLVs) encapsulating pilocarpine HCl. The results showed that administration with neutral MLVs displayed the most prolonged effect with respect to negatively charged MLVs and free drug. The efficiency of MLVs encapsulating pilocarpine HCl, measured using spectrophotometric technique, was found to be 96% in our modified preparations. The storage stability of MLVs encapsulating pilocarpine HCl was investigated by measuring phase transition and size distribution using light scattering technique. The results show that liposomes encapsulating pilocarpine HCl have kept their integrity and physicochemical properties for at least 15 months, which makes them suitable for commercial use. SN - 0378-5173 UR - https://www.unboundmedicine.com/medline/citation/10722948/Prolonged_effect_of_liposomes_encapsulating_pilocarpine_HCl_in_normal_and_glaucomatous_rabbits_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(99)00348-8 DB - PRIME DP - Unbound Medicine ER -