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Frequency and allelic association of common variants in the lipoprotein lipase gene in different ethnic groups: the Wandsworth Heart and Stroke Study.
Genet Epidemiol. 2000 Mar; 18(3):203-16.GE

Abstract

The lower serum triglyceride (Tg), higher high density cholesterol (HDL-C) levels and low coronary heart disease (CHD) mortality in black populations, contrast with that in whites. By comparison, South Asian populations display a higher mortality from CHD associated with increased Tg and low HDL-C levels. Lipoprotein lipase (LPL) plays a major role in Tg metabolism. To determine if variation in the LPL gene contributes to the differences in lipid levels, we studied the frequencies and allelic associations of five common variants in the lipoprotein lipase (LPL) gene (-93T/G, D9N, N291S, S447X, and the HinddIII RFLP in intron 8) with serum Tg and HDL-cholesterol concentrations in population samples of middle-aged men and women of whites, South Asians, and blacks of African origin co-resident in South London. Significantly higher frequencies of the H(-) (P < 0.00001), N9 (P < 0.001), and -93G (P < 10(-10)) alleles were seen in blacks compared to the other two groups. Allelic association between -93G and N9, and H(+) and X447 was strong in all three groups. However, no association was observed between serum Tg and HDL-cholesterol concentrations and these variants in the three ethnic groups. A single common polymorphism in the LPL gene is unlikely to account for the differences in fasting serum Tg in populations of different ethnic background. The importance of the differences in frequencies and the mechanism(s) whereby these may contribute towards a beneficial LPL genotype in black populations remain to be determined.

Authors+Show Affiliations

Division of Cardiovascular Genetics, Department of Medicine, University College London, London, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10723106

Citation

Hall, S, et al. "Frequency and Allelic Association of Common Variants in the Lipoprotein Lipase Gene in Different Ethnic Groups: the Wandsworth Heart and Stroke Study." Genetic Epidemiology, vol. 18, no. 3, 2000, pp. 203-16.
Hall S, Talmud PJ, Cook DG, et al. Frequency and allelic association of common variants in the lipoprotein lipase gene in different ethnic groups: the Wandsworth Heart and Stroke Study. Genet Epidemiol. 2000;18(3):203-16.
Hall, S., Talmud, P. J., Cook, D. G., Wicks, P. D., Rothwell, M. J., Strazzullo, P., Sagnella, G. A., & Cappuccio, F. P. (2000). Frequency and allelic association of common variants in the lipoprotein lipase gene in different ethnic groups: the Wandsworth Heart and Stroke Study. Genetic Epidemiology, 18(3), 203-16.
Hall S, et al. Frequency and Allelic Association of Common Variants in the Lipoprotein Lipase Gene in Different Ethnic Groups: the Wandsworth Heart and Stroke Study. Genet Epidemiol. 2000;18(3):203-16. PubMed PMID: 10723106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Frequency and allelic association of common variants in the lipoprotein lipase gene in different ethnic groups: the Wandsworth Heart and Stroke Study. AU - Hall,S, AU - Talmud,P J, AU - Cook,D G, AU - Wicks,P D, AU - Rothwell,M J, AU - Strazzullo,P, AU - Sagnella,G A, AU - Cappuccio,F P, PY - 2000/3/21/pubmed PY - 2000/5/16/medline PY - 2000/3/21/entrez SP - 203 EP - 16 JF - Genetic epidemiology JO - Genet Epidemiol VL - 18 IS - 3 N2 - The lower serum triglyceride (Tg), higher high density cholesterol (HDL-C) levels and low coronary heart disease (CHD) mortality in black populations, contrast with that in whites. By comparison, South Asian populations display a higher mortality from CHD associated with increased Tg and low HDL-C levels. Lipoprotein lipase (LPL) plays a major role in Tg metabolism. To determine if variation in the LPL gene contributes to the differences in lipid levels, we studied the frequencies and allelic associations of five common variants in the lipoprotein lipase (LPL) gene (-93T/G, D9N, N291S, S447X, and the HinddIII RFLP in intron 8) with serum Tg and HDL-cholesterol concentrations in population samples of middle-aged men and women of whites, South Asians, and blacks of African origin co-resident in South London. Significantly higher frequencies of the H(-) (P < 0.00001), N9 (P < 0.001), and -93G (P < 10(-10)) alleles were seen in blacks compared to the other two groups. Allelic association between -93G and N9, and H(+) and X447 was strong in all three groups. However, no association was observed between serum Tg and HDL-cholesterol concentrations and these variants in the three ethnic groups. A single common polymorphism in the LPL gene is unlikely to account for the differences in fasting serum Tg in populations of different ethnic background. The importance of the differences in frequencies and the mechanism(s) whereby these may contribute towards a beneficial LPL genotype in black populations remain to be determined. SN - 0741-0395 UR - https://www.unboundmedicine.com/medline/citation/10723106/Frequency_and_allelic_association_of_common_variants_in_the_lipoprotein_lipase_gene_in_different_ethnic_groups:_the_Wandsworth_Heart_and_Stroke_Study_ L2 - https://doi.org/10.1002/(SICI)1098-2272(200003)18:3&lt;203::AID-GEPI2&gt;3.0.CO;2-I DB - PRIME DP - Unbound Medicine ER -