Tags

Type your tag names separated by a space and hit enter

Family risk score of coronary heart disease (CHD) as a predictor of CHD: the Atherosclerosis Risk in Communities (ARIC) study and the NHLBI family heart study.
Genet Epidemiol 2000; 18(3):236-50GE

Abstract

Family history of coronary heart disease (CHD) has been found to be a risk factor for CHD in numerous studies. Few studies have addressed whether a quantitative measure of family history of CHD (family risk score, FRS) predicts CHD in African Americans. This study assessed the association between FRS and incident CHD of participants, and the variation of the association by gender and race. Participants in the study were a biracial population-based cohort with 3,958 African Americans and 10,580 Whites aged 45-64 years old in the ARIC baseline survey (1987-1989). They were randomly selected from four U. S. communities. During follow-up (1987-1993), 352 participants experienced the onset of CHD. Incidence density of CHD (per 1,000 person-years) was 7.8 and 3.6 among African-American men (AAM) and women (AAW), and 7.2 and 2.2 among White men (WM) and women (WW). The hazard rate ratio (HRR) of CHD associated with one standard deviation increase of FRS was 1.52 in AAW, 1.46 in AAM, 1.41 in WW, and 1.68 in WM. The HRRs decreased 4.6% in AAW, 1.4% in WW, 5.7% in AAM, and 3.0% in WM, but increased 2.1% in AAM after adjustment for selected covariates. FRS predicts incident CHD in African Americans and Whites, men and women. The relation of FRS to incident CHD can be only partially explained by the selected risk factors in the biological causal pathways: IMT, T-G, LDL, HDL, Lp(a), fibrinogen and hypertension. No significant difference by race has been found in this study.

Authors+Show Affiliations

Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-8050, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10723108

Citation

Li, R, et al. "Family Risk Score of Coronary Heart Disease (CHD) as a Predictor of CHD: the Atherosclerosis Risk in Communities (ARIC) Study and the NHLBI Family Heart Study." Genetic Epidemiology, vol. 18, no. 3, 2000, pp. 236-50.
Li R, Bensen JT, Hutchinson RG, et al. Family risk score of coronary heart disease (CHD) as a predictor of CHD: the Atherosclerosis Risk in Communities (ARIC) study and the NHLBI family heart study. Genet Epidemiol. 2000;18(3):236-50.
Li, R., Bensen, J. T., Hutchinson, R. G., Province, M. A., Hertz-Picciotto, I., Sprafka, J. M., & Tyroler, H. A. (2000). Family risk score of coronary heart disease (CHD) as a predictor of CHD: the Atherosclerosis Risk in Communities (ARIC) study and the NHLBI family heart study. Genetic Epidemiology, 18(3), pp. 236-50.
Li R, et al. Family Risk Score of Coronary Heart Disease (CHD) as a Predictor of CHD: the Atherosclerosis Risk in Communities (ARIC) Study and the NHLBI Family Heart Study. Genet Epidemiol. 2000;18(3):236-50. PubMed PMID: 10723108.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Family risk score of coronary heart disease (CHD) as a predictor of CHD: the Atherosclerosis Risk in Communities (ARIC) study and the NHLBI family heart study. AU - Li,R, AU - Bensen,J T, AU - Hutchinson,R G, AU - Province,M A, AU - Hertz-Picciotto,I, AU - Sprafka,J M, AU - Tyroler,H A, PY - 2000/3/21/pubmed PY - 2000/5/16/medline PY - 2000/3/21/entrez SP - 236 EP - 50 JF - Genetic epidemiology JO - Genet. Epidemiol. VL - 18 IS - 3 N2 - Family history of coronary heart disease (CHD) has been found to be a risk factor for CHD in numerous studies. Few studies have addressed whether a quantitative measure of family history of CHD (family risk score, FRS) predicts CHD in African Americans. This study assessed the association between FRS and incident CHD of participants, and the variation of the association by gender and race. Participants in the study were a biracial population-based cohort with 3,958 African Americans and 10,580 Whites aged 45-64 years old in the ARIC baseline survey (1987-1989). They were randomly selected from four U. S. communities. During follow-up (1987-1993), 352 participants experienced the onset of CHD. Incidence density of CHD (per 1,000 person-years) was 7.8 and 3.6 among African-American men (AAM) and women (AAW), and 7.2 and 2.2 among White men (WM) and women (WW). The hazard rate ratio (HRR) of CHD associated with one standard deviation increase of FRS was 1.52 in AAW, 1.46 in AAM, 1.41 in WW, and 1.68 in WM. The HRRs decreased 4.6% in AAW, 1.4% in WW, 5.7% in AAM, and 3.0% in WM, but increased 2.1% in AAM after adjustment for selected covariates. FRS predicts incident CHD in African Americans and Whites, men and women. The relation of FRS to incident CHD can be only partially explained by the selected risk factors in the biological causal pathways: IMT, T-G, LDL, HDL, Lp(a), fibrinogen and hypertension. No significant difference by race has been found in this study. SN - 0741-0395 UR - https://www.unboundmedicine.com/medline/citation/10723108/Family_risk_score_of_coronary_heart_disease__CHD__as_a_predictor_of_CHD:_the_Atherosclerosis_Risk_in_Communities__ARIC__study_and_the_NHLBI_family_heart_study_ L2 - https://doi.org/10.1002/(SICI)1098-2272(200003)18:3<236::AID-GEPI4>3.0.CO;2-0 DB - PRIME DP - Unbound Medicine ER -