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Evidence for an anabolic action of essential amino acid analogues in uremia and starvation.
Z Ernahrungswiss Suppl 1976 Jun 17-19; (19):5-12ZE

Abstract

Nitrogen-free analogues of essential amino acids, when administered with those essential amino acids for which analogues are ineffective or unavailable, exert three actions that may be beneficial in protein-deficient or protein-intolerant subjects. First, they bring about an increase in the concentrations of essential amino acids in the blood at the expense of the concentrations of certain non-essential amino acids, notably alanine and glutamine. This effect is most readily demonstrated in children with congenital defects of the urea cycle enzymes, but can also be seen during daily therapy of adults with portal-systemic encephalopathy. Second, these compounds promote nitrogen balance through their suppressive effect on urea synthesis (an effect not attributable to re-utilization of ammonia derived from urease action in the gut). This action is demonstrable in obese subjects who are already conserving nitrogen maximally at the end of a prolonged fast and can also be shown in the first week of fasting when the branched-chain keto acids alone are administered. In both situations, improved nitrogen conservation persists long after the analogues are metabolized, suggesting enzyme adaptations. In chronic uremics, nitrogen balance can be maintained in some (but not all) patients on very low nitrogen intakes. Third, these mixtures may delay or reverse the progressive decline in glomerular filtration rate characteristic of chronic renal failure in some cases: thus, for example, 5 of 6 patients taken off chronic dialysis have maintained lower serum urea concentrations without evidence of protein malnutrition for periods of 2-24 months.

Authors

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Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

1072939

Citation

Walser, M, et al. "Evidence for an Anabolic Action of Essential Amino Acid Analogues in Uremia and Starvation." Zeitschrift Fur Ernahrungswissenschaft. Journal of Nutritional Sciences. Supplementa, 1976, pp. 5-12.
Walser M, Sapir DG, Mitch WE, et al. Evidence for an anabolic action of essential amino acid analogues in uremia and starvation. Z Ernahrungswiss Suppl. 1976.
Walser, M., Sapir, D. G., Mitch, W. E., Batshaw, M., Brusilow, S., & Maddrey, W. C. (1976). Evidence for an anabolic action of essential amino acid analogues in uremia and starvation. Zeitschrift Fur Ernahrungswissenschaft. Journal of Nutritional Sciences. Supplementa, (19), pp. 5-12.
Walser M, et al. Evidence for an Anabolic Action of Essential Amino Acid Analogues in Uremia and Starvation. Z Ernahrungswiss Suppl. 1976;(19)5-12. PubMed PMID: 1072939.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence for an anabolic action of essential amino acid analogues in uremia and starvation. AU - Walser,M, AU - Sapir,D G, AU - Mitch,W E, AU - Batshaw,M, AU - Brusilow,S, AU - Maddrey,W C, PY - 1976/6/17/pubmed PY - 1976/6/17/medline PY - 1976/6/17/entrez SP - 5 EP - 12 JF - Zeitschrift fur Ernahrungswissenschaft. Journal of nutritional sciences. Supplementa JO - Z Ernahrungswiss Suppl IS - 19 N2 - Nitrogen-free analogues of essential amino acids, when administered with those essential amino acids for which analogues are ineffective or unavailable, exert three actions that may be beneficial in protein-deficient or protein-intolerant subjects. First, they bring about an increase in the concentrations of essential amino acids in the blood at the expense of the concentrations of certain non-essential amino acids, notably alanine and glutamine. This effect is most readily demonstrated in children with congenital defects of the urea cycle enzymes, but can also be seen during daily therapy of adults with portal-systemic encephalopathy. Second, these compounds promote nitrogen balance through their suppressive effect on urea synthesis (an effect not attributable to re-utilization of ammonia derived from urease action in the gut). This action is demonstrable in obese subjects who are already conserving nitrogen maximally at the end of a prolonged fast and can also be shown in the first week of fasting when the branched-chain keto acids alone are administered. In both situations, improved nitrogen conservation persists long after the analogues are metabolized, suggesting enzyme adaptations. In chronic uremics, nitrogen balance can be maintained in some (but not all) patients on very low nitrogen intakes. Third, these mixtures may delay or reverse the progressive decline in glomerular filtration rate characteristic of chronic renal failure in some cases: thus, for example, 5 of 6 patients taken off chronic dialysis have maintained lower serum urea concentrations without evidence of protein malnutrition for periods of 2-24 months. SN - 0084-5337 UR - https://www.unboundmedicine.com/medline/citation/1072939/Evidence_for_an_anabolic_action_of_essential_amino_acid_analogues_in_uremia_and_starvation_ DB - PRIME DP - Unbound Medicine ER -