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[Dementia with Lewy bodies].
Neurologia. 2000 Jan; 15(1):15-21.N

Abstract

Dementia with Lewy bodies (DLB) is the second most frequent cause of primary degenerative dementias, following Alzheimer's disease (AD). The nosologic situation of this disease has fragile limits. There is controversy as to whether Parkinson's disease (PD) and DLB are two different entities or whether they make up part of the same spectrum. The terms diffuse Lewy bodies disease and the variant of Lewy bodies in senile dementia or AD have been used to describe pathologic changes with clinical manifestations of dementia and parkinsonism. At present, DLB should be understood as an entity with the essential feature being the presence of Lewy bodies in the brain stem and cerebral cortex. From the point of view of clinical examination, DLB is characterized by the presence of subcortical or progressive cortical dementia, at times without severe memory disorders, with great fluctuations and well detailed recurrent visual hallucinations. These cognitive alterations are associated with parkinsonism. Other frequent disorders are falls, syncopes, transitory alterations in consciousness, great sensitivity to neuroleptic drugs and visual illusions with pseudoperception. The correct diagnosis of this entity is important to administer adequate treatment, to avoid classical neuroleptic drugs and to establish precise prognosis. From a therapeutic point of view, cholinesterase inhibitors show some efficacy in the treatment of cognitive alterations.

Authors+Show Affiliations

Servicio de Neurología, Hospital Nuestra Señora de Aránzazu, San Sebastián.No affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

spa

PubMed ID

10730062

Citation

Martí Massó, J F., and J Ruiz Martínez. "[Dementia With Lewy Bodies]." Neurologia (Barcelona, Spain), vol. 15, no. 1, 2000, pp. 15-21.
Martí Massó JF, Ruiz Martínez J. [Dementia with Lewy bodies]. Neurologia. 2000;15(1):15-21.
Martí Massó, J. F., & Ruiz Martínez, J. (2000). [Dementia with Lewy bodies]. Neurologia (Barcelona, Spain), 15(1), 15-21.
Martí Massó JF, Ruiz Martínez J. [Dementia With Lewy Bodies]. Neurologia. 2000;15(1):15-21. PubMed PMID: 10730062.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Dementia with Lewy bodies]. AU - Martí Massó,J F, AU - Ruiz Martínez,J, PY - 2000/3/24/pubmed PY - 2000/5/16/medline PY - 2000/3/24/entrez SP - 15 EP - 21 JF - Neurologia (Barcelona, Spain) JO - Neurologia VL - 15 IS - 1 N2 - Dementia with Lewy bodies (DLB) is the second most frequent cause of primary degenerative dementias, following Alzheimer's disease (AD). The nosologic situation of this disease has fragile limits. There is controversy as to whether Parkinson's disease (PD) and DLB are two different entities or whether they make up part of the same spectrum. The terms diffuse Lewy bodies disease and the variant of Lewy bodies in senile dementia or AD have been used to describe pathologic changes with clinical manifestations of dementia and parkinsonism. At present, DLB should be understood as an entity with the essential feature being the presence of Lewy bodies in the brain stem and cerebral cortex. From the point of view of clinical examination, DLB is characterized by the presence of subcortical or progressive cortical dementia, at times without severe memory disorders, with great fluctuations and well detailed recurrent visual hallucinations. These cognitive alterations are associated with parkinsonism. Other frequent disorders are falls, syncopes, transitory alterations in consciousness, great sensitivity to neuroleptic drugs and visual illusions with pseudoperception. The correct diagnosis of this entity is important to administer adequate treatment, to avoid classical neuroleptic drugs and to establish precise prognosis. From a therapeutic point of view, cholinesterase inhibitors show some efficacy in the treatment of cognitive alterations. SN - 0213-4853 UR - https://www.unboundmedicine.com/medline/citation/10730062/[Dementia_with_Lewy_bodies]_ L2 - https://medlineplus.gov/parkinsonsdisease.html DB - PRIME DP - Unbound Medicine ER -
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