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Changes in iron status during pregnancy in peruvian women receiving prenatal iron and folic acid supplements with or without zinc.
Am J Clin Nutr. 2000 Apr; 71(4):956-61.AJ

Abstract

BACKGROUND

Iron deficiency anemia is the most prevalent nutrient deficiency during pregnancy, yet there are few data on the effect of prenatal iron supplementation in women in developing countries.

OBJECTIVE

Our objective was to describe the effect of iron supplementation on hematologic changes during pregnancy, and the effect on those changes of adding zinc to the supplements.

DESIGN

Pregnant women were enrolled in a randomized, double-masked study conducted at a hospital in a shantytown in Lima, Peru. Women were supplemented daily from 10-24 wk gestation to 4 wk postpartum with 60 mg Fe and 250 microg folic acid with or without 15 mg Zn. Hemoglobin and ferritin concentrations were measured in 645 and 613 women, respectively, at enrollment, at 28-30 and 37-38 wk gestation, and in the cord blood of 545 neonates.

RESULTS

No differences in iron status were detected by supplement type, but hematologic changes were related to initial hemoglobin status. Women with anemia (hemoglobin <110 g/L) showed steady increases in hemoglobin concentration throughout pregnancy whereas women with relatively higher initial hemoglobin concentrations had declining values during mid pregnancy, then rising values by 37-38 wk gestation. Women with an initial hemoglobin concentration >95 g/L showed increases in serum ferritin by the end of the pregnancy. Despite supplementation, women with poorer hematologic status; who were younger, single, and multiparous; and who consumed fewer supplements were more likely to have anemia at the end of pregnancy.

CONCLUSIONS

These hematologic changes are congruent with the effects of iron supplementation reported in placebo-controlled trials and the addition of zinc did not significantly affect them.

Authors+Show Affiliations

Instituto de Investigación Nutricional, Lima, Peru. nzavalet@iin.sld.peNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

10731503

Citation

Zavaleta, N, et al. "Changes in Iron Status During Pregnancy in Peruvian Women Receiving Prenatal Iron and Folic Acid Supplements With or Without Zinc." The American Journal of Clinical Nutrition, vol. 71, no. 4, 2000, pp. 956-61.
Zavaleta N, Caulfield LE, Garcia T. Changes in iron status during pregnancy in peruvian women receiving prenatal iron and folic acid supplements with or without zinc. Am J Clin Nutr. 2000;71(4):956-61.
Zavaleta, N., Caulfield, L. E., & Garcia, T. (2000). Changes in iron status during pregnancy in peruvian women receiving prenatal iron and folic acid supplements with or without zinc. The American Journal of Clinical Nutrition, 71(4), 956-61.
Zavaleta N, Caulfield LE, Garcia T. Changes in Iron Status During Pregnancy in Peruvian Women Receiving Prenatal Iron and Folic Acid Supplements With or Without Zinc. Am J Clin Nutr. 2000;71(4):956-61. PubMed PMID: 10731503.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in iron status during pregnancy in peruvian women receiving prenatal iron and folic acid supplements with or without zinc. AU - Zavaleta,N, AU - Caulfield,L E, AU - Garcia,T, PY - 2000/3/25/pubmed PY - 2000/4/25/medline PY - 2000/3/25/entrez SP - 956 EP - 61 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 71 IS - 4 N2 - BACKGROUND: Iron deficiency anemia is the most prevalent nutrient deficiency during pregnancy, yet there are few data on the effect of prenatal iron supplementation in women in developing countries. OBJECTIVE: Our objective was to describe the effect of iron supplementation on hematologic changes during pregnancy, and the effect on those changes of adding zinc to the supplements. DESIGN: Pregnant women were enrolled in a randomized, double-masked study conducted at a hospital in a shantytown in Lima, Peru. Women were supplemented daily from 10-24 wk gestation to 4 wk postpartum with 60 mg Fe and 250 microg folic acid with or without 15 mg Zn. Hemoglobin and ferritin concentrations were measured in 645 and 613 women, respectively, at enrollment, at 28-30 and 37-38 wk gestation, and in the cord blood of 545 neonates. RESULTS: No differences in iron status were detected by supplement type, but hematologic changes were related to initial hemoglobin status. Women with anemia (hemoglobin <110 g/L) showed steady increases in hemoglobin concentration throughout pregnancy whereas women with relatively higher initial hemoglobin concentrations had declining values during mid pregnancy, then rising values by 37-38 wk gestation. Women with an initial hemoglobin concentration >95 g/L showed increases in serum ferritin by the end of the pregnancy. Despite supplementation, women with poorer hematologic status; who were younger, single, and multiparous; and who consumed fewer supplements were more likely to have anemia at the end of pregnancy. CONCLUSIONS: These hematologic changes are congruent with the effects of iron supplementation reported in placebo-controlled trials and the addition of zinc did not significantly affect them. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/10731503/Changes_in_iron_status_during_pregnancy_in_peruvian_women_receiving_prenatal_iron_and_folic_acid_supplements_with_or_without_zinc_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/71.4.956 DB - PRIME DP - Unbound Medicine ER -