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RETRACTED ARTICLE

A comparison of urapidil, clonidine, meperidine and placebo in preventing postanesthetic shivering.
Anesth Analg. 2000 Apr; 90(4):954-7.A&A

Abstract

This placebo-controlled study was performed to evaluate the efficacy of urapidil compared with clonidine and meperidine in preventing postanesthetic shivering, which is common after anesthesia administration and may be very distressing. We studied 120 patients undergoing elective abdominal or orthopedic surgery under standardized general anesthesia. After surgery, patients were randomly assigned to one of four groups (each group n = 30) using a double-blinded protocol: Group A received 0.2 mg/kg urapidil; Group B, 3 microg/kg clonidine; Group C, 0.4 mg/kg meperidine; and Group D, saline 0.9% as placebo. Postanesthetic shivering was scored by using a five-point scale. Clonidine and meperidine significantly reduced the incidence and the severity of shivering in comparison with placebo, whereas there were no significant differences between the urapidil and placebo groups. Both clonidine and meperidine caused a significantly prolonged emergence time (13.4 +/- 5.8 and 13. 3 +/- 5.0 min, respectively) compared with placebo (10.4 +/- 5.3 min) and urapidil (11.4 +/- 2.9 min). We confirmed that both clonidine and meperidine are effective in preventing postanesthetic shivering, whereas urapidil, in our setting and dosage, was not effective. Patients who received clonidine or meperidine had a prolonged emergence time. In the dosage used, urapidil seems to be unable to prevent postanesthetic shivering.

IMPLICATIONS

Shivering (irregular muscle activity) is common after surgery and anesthesia. This study compared urapidil (an antihypertensive drug) as a prophylaxis with two established antishivering drugs (meperidine and clonidine) and placebo. In the dosage used, we were unable to show a significant benefit of urapidil.

Authors+Show Affiliations

Department of Anesthesiology and Critical Care, Hospital of the City Ludwigshafen, Ludwigshafen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Retracted Publication

Language

eng

PubMed ID

10735806

Citation

Piper, S N., et al. "A Comparison of Urapidil, Clonidine, Meperidine and Placebo in Preventing Postanesthetic Shivering." Anesthesia and Analgesia, vol. 90, no. 4, 2000, pp. 954-7.
Piper SN, Maleck WH, Boldt J, et al. A comparison of urapidil, clonidine, meperidine and placebo in preventing postanesthetic shivering. Anesth Analg. 2000;90(4):954-7.
Piper, S. N., Maleck, W. H., Boldt, J., Suttner, S. W., Schmidt, C. C., & Reich, D. G. (2000). A comparison of urapidil, clonidine, meperidine and placebo in preventing postanesthetic shivering. Anesthesia and Analgesia, 90(4), 954-7.
Piper SN, et al. A Comparison of Urapidil, Clonidine, Meperidine and Placebo in Preventing Postanesthetic Shivering. Anesth Analg. 2000;90(4):954-7. PubMed PMID: 10735806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of urapidil, clonidine, meperidine and placebo in preventing postanesthetic shivering. AU - Piper,S N, AU - Maleck,W H, AU - Boldt,J, AU - Suttner,S W, AU - Schmidt,C C, AU - Reich,D G, PY - 2000/3/29/pubmed PY - 2000/4/25/medline PY - 2000/3/29/entrez SP - 954 EP - 7 JF - Anesthesia and analgesia JO - Anesth. Analg. VL - 90 IS - 4 N2 - UNLABELLED: This placebo-controlled study was performed to evaluate the efficacy of urapidil compared with clonidine and meperidine in preventing postanesthetic shivering, which is common after anesthesia administration and may be very distressing. We studied 120 patients undergoing elective abdominal or orthopedic surgery under standardized general anesthesia. After surgery, patients were randomly assigned to one of four groups (each group n = 30) using a double-blinded protocol: Group A received 0.2 mg/kg urapidil; Group B, 3 microg/kg clonidine; Group C, 0.4 mg/kg meperidine; and Group D, saline 0.9% as placebo. Postanesthetic shivering was scored by using a five-point scale. Clonidine and meperidine significantly reduced the incidence and the severity of shivering in comparison with placebo, whereas there were no significant differences between the urapidil and placebo groups. Both clonidine and meperidine caused a significantly prolonged emergence time (13.4 +/- 5.8 and 13. 3 +/- 5.0 min, respectively) compared with placebo (10.4 +/- 5.3 min) and urapidil (11.4 +/- 2.9 min). We confirmed that both clonidine and meperidine are effective in preventing postanesthetic shivering, whereas urapidil, in our setting and dosage, was not effective. Patients who received clonidine or meperidine had a prolonged emergence time. In the dosage used, urapidil seems to be unable to prevent postanesthetic shivering. IMPLICATIONS: Shivering (irregular muscle activity) is common after surgery and anesthesia. This study compared urapidil (an antihypertensive drug) as a prophylaxis with two established antishivering drugs (meperidine and clonidine) and placebo. In the dosage used, we were unable to show a significant benefit of urapidil. SN - 0003-2999 UR - https://www.unboundmedicine.com/medline/citation/10735806/A_comparison_of_urapidil_clonidine_meperidine_and_placebo_in_preventing_postanesthetic_shivering_ L2 - http://dx.doi.org/10.1097/00000539-200004000-00033 DB - PRIME DP - Unbound Medicine ER -