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Histopathology and APOE genotype of the first Alzheimer disease patient, Auguste D.
Neurogenetics. 1998 Mar; 1(3):223-8.N

Abstract

Alois Alzheimer published two papers on the disease which was named after him by Emil Kraepelin in 1910. Each of these papers contains clinical and pathological data on a patient Alzheimer had seen at the hospital. We have previously reported on the rediscovery of tissue sections from Alzheimer's second published case of Alzheimer disease, Johann F., which probably gave the disease its name (Neurogenetics 1997; 1:73-80). Here, we describe the histopathology and APOE genotype of Alois Alzheimer's first patient, Auguste D. As in the case of Johann F., a large number of tissue sections belonging to Alzheimer's laboratory, which was later headed by Spielmeyer, were found among material kept at the Institute of Neuropathology of the University of Munich. As described by Alzheimer in his original report (Allg Zeitschr Psychiatr 1907; 64:146-148), there were numerous neurofibrillary tangles and many amyloid plaques, especially in the upper cortical layers of this patient. Yet, there was no microscopic evidence for vascular, i.e., arteriosclerotic, lesions. Interestingly, Alzheimer's histological preparations did not include the hippocampus or entorhinal region. The APOE genotype of this patient was shown to be epsilon3/epsilon3 by PCR-based restriction enzyme analysis, indicating that mutational screening of the tissue is feasible. The historical importance of the case of Auguste D. lies in the fact that it marks the beginning of research into Alzheimer disease. In addition, neurofibrillary tangles were first described in this brain.

Authors+Show Affiliations

Department of Neuromorphology, Max Planck Institute of Neurobiology, Martinsried, Germany. neuropat@neuro.mpg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Biography
Historical Article
Journal Article

Language

eng

PubMed ID

10737127

Citation

Graeber, M B., et al. "Histopathology and APOE Genotype of the First Alzheimer Disease Patient, Auguste D." Neurogenetics, vol. 1, no. 3, 1998, pp. 223-8.
Graeber MB, Kösel S, Grasbon-Frodl E, et al. Histopathology and APOE genotype of the first Alzheimer disease patient, Auguste D. Neurogenetics. 1998;1(3):223-8.
Graeber, M. B., Kösel, S., Grasbon-Frodl, E., Möller, H. J., & Mehraein, P. (1998). Histopathology and APOE genotype of the first Alzheimer disease patient, Auguste D. Neurogenetics, 1(3), 223-8.
Graeber MB, et al. Histopathology and APOE Genotype of the First Alzheimer Disease Patient, Auguste D. Neurogenetics. 1998;1(3):223-8. PubMed PMID: 10737127.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histopathology and APOE genotype of the first Alzheimer disease patient, Auguste D. AU - Graeber,M B, AU - Kösel,S, AU - Grasbon-Frodl,E, AU - Möller,H J, AU - Mehraein,P, PY - 2000/3/29/pubmed PY - 2000/4/15/medline PY - 2000/3/29/entrez SP - 223 EP - 8 JF - Neurogenetics JO - Neurogenetics VL - 1 IS - 3 N2 - Alois Alzheimer published two papers on the disease which was named after him by Emil Kraepelin in 1910. Each of these papers contains clinical and pathological data on a patient Alzheimer had seen at the hospital. We have previously reported on the rediscovery of tissue sections from Alzheimer's second published case of Alzheimer disease, Johann F., which probably gave the disease its name (Neurogenetics 1997; 1:73-80). Here, we describe the histopathology and APOE genotype of Alois Alzheimer's first patient, Auguste D. As in the case of Johann F., a large number of tissue sections belonging to Alzheimer's laboratory, which was later headed by Spielmeyer, were found among material kept at the Institute of Neuropathology of the University of Munich. As described by Alzheimer in his original report (Allg Zeitschr Psychiatr 1907; 64:146-148), there were numerous neurofibrillary tangles and many amyloid plaques, especially in the upper cortical layers of this patient. Yet, there was no microscopic evidence for vascular, i.e., arteriosclerotic, lesions. Interestingly, Alzheimer's histological preparations did not include the hippocampus or entorhinal region. The APOE genotype of this patient was shown to be epsilon3/epsilon3 by PCR-based restriction enzyme analysis, indicating that mutational screening of the tissue is feasible. The historical importance of the case of Auguste D. lies in the fact that it marks the beginning of research into Alzheimer disease. In addition, neurofibrillary tangles were first described in this brain. SN - 1364-6745 UR - https://www.unboundmedicine.com/medline/citation/10737127/Histopathology_and_APOE_genotype_of_the_first_Alzheimer_disease_patient_Auguste_D_ L2 - https://dx.doi.org/10.1007/s100480050033 DB - PRIME DP - Unbound Medicine ER -