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Role of gender and genetic variance in plasminogen activator inhibitor-1 secretion from human adipose tissue.
Thromb Haemost 2000; 83(2):304-8TH

Abstract

Gender and the 4G/5G polymorphism in the plasminogen activator inhibitor 1 (PAI-1) gene are believed to play a role in the regulation of plasma PAI-1 activity. Adipose tissue has been found to be an important source of PAI-1. The possible influence of gender and the 4G/5G polymorphism in the PAI-1 gene on PAI-1 secretion from abdominal subcutaneous adipose tissue was investigated in 59 women and 32 men. The subjects were apparently healthy, although they differed markedly inter-individually in body mass index (21-53 kg/m2). The 4G/5G polymorphism did not influence the adipose secretion rate of PAI-1 or plasma PAI-1 activity. There was no gender difference in the adipose secretion of PAI-1. In multiple regression, including body mass index (BMI), waist-to-hip ratio (WHR), plasma insulin and plasma triglycerides as the independent and adipose PAI-1 secretion as the dependent variable, only BMI and plasma triglycerides correlated independently with adipose PAI-1 secretion (r = 0.54, p <0.05; r = 0.51, p <0.05, respectively). Men had a two times higher plasma PAI-1 activity than women (p <0.05). This gender difference was mainly due to gender differences in WHR. In multiple regression analysis, BMI and WHR were identified to be independently correlated with plasma PAI-1 activity (r = 0.60, p <0.05; r = 0.52, p = 0.01, respectively). In conclusion, neither gender nor the 4G/5G polymorphism in the PAI-1 gene are associated with secretion of PAI-1 from abdominal subcutaneous adipose tissue.

Authors+Show Affiliations

Department of Medicine and Research Center, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden. vanessa.van.harmelen@kfcmail.hs.sll.seNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10739390

Citation

van Harmelen, V, et al. "Role of Gender and Genetic Variance in Plasminogen Activator Inhibitor-1 Secretion From Human Adipose Tissue." Thrombosis and Haemostasis, vol. 83, no. 2, 2000, pp. 304-8.
van Harmelen V, Wahrenberg H, Eriksson P, et al. Role of gender and genetic variance in plasminogen activator inhibitor-1 secretion from human adipose tissue. Thromb Haemost. 2000;83(2):304-8.
van Harmelen, V., Wahrenberg, H., Eriksson, P., & Arner, P. (2000). Role of gender and genetic variance in plasminogen activator inhibitor-1 secretion from human adipose tissue. Thrombosis and Haemostasis, 83(2), pp. 304-8.
van Harmelen V, et al. Role of Gender and Genetic Variance in Plasminogen Activator Inhibitor-1 Secretion From Human Adipose Tissue. Thromb Haemost. 2000;83(2):304-8. PubMed PMID: 10739390.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of gender and genetic variance in plasminogen activator inhibitor-1 secretion from human adipose tissue. AU - van Harmelen,V, AU - Wahrenberg,H, AU - Eriksson,P, AU - Arner,P, PY - 2000/3/30/pubmed PY - 2000/5/16/medline PY - 2000/3/30/entrez SP - 304 EP - 8 JF - Thrombosis and haemostasis JO - Thromb. Haemost. VL - 83 IS - 2 N2 - Gender and the 4G/5G polymorphism in the plasminogen activator inhibitor 1 (PAI-1) gene are believed to play a role in the regulation of plasma PAI-1 activity. Adipose tissue has been found to be an important source of PAI-1. The possible influence of gender and the 4G/5G polymorphism in the PAI-1 gene on PAI-1 secretion from abdominal subcutaneous adipose tissue was investigated in 59 women and 32 men. The subjects were apparently healthy, although they differed markedly inter-individually in body mass index (21-53 kg/m2). The 4G/5G polymorphism did not influence the adipose secretion rate of PAI-1 or plasma PAI-1 activity. There was no gender difference in the adipose secretion of PAI-1. In multiple regression, including body mass index (BMI), waist-to-hip ratio (WHR), plasma insulin and plasma triglycerides as the independent and adipose PAI-1 secretion as the dependent variable, only BMI and plasma triglycerides correlated independently with adipose PAI-1 secretion (r = 0.54, p <0.05; r = 0.51, p <0.05, respectively). Men had a two times higher plasma PAI-1 activity than women (p <0.05). This gender difference was mainly due to gender differences in WHR. In multiple regression analysis, BMI and WHR were identified to be independently correlated with plasma PAI-1 activity (r = 0.60, p <0.05; r = 0.52, p = 0.01, respectively). In conclusion, neither gender nor the 4G/5G polymorphism in the PAI-1 gene are associated with secretion of PAI-1 from abdominal subcutaneous adipose tissue. SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/10739390/Role_of_gender_and_genetic_variance_in_plasminogen_activator_inhibitor_1_secretion_from_human_adipose_tissue_ DB - PRIME DP - Unbound Medicine ER -