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The chemical composition of tooth enamel in junctional epidermolysis bullosa.
Arch Oral Biol. 2000 May; 45(5):377-86.AO

Abstract

The junctionalis form of epidermolysis bullosa (EBJ) is associated with a number of clinical problems involving tooth enamel, including increased susceptibility to caries. The aim here was to carry out a chemical characterization of the enamel of teeth from EBJ patients compared with that of unaffected controls. The results showed that while protein concentration, amino acid composition and carbonate content were similar in both groups, EBJ enamel contained a significantly reduced mineral per volume content, resulting in enamel hypoplasia. In addition, Western blotting revealed the presence of serum albumin (a known inhibitor of enamel crystal growth) in EBJ enamel. This was not detected in control enamel or in enamel of teeth from patients with the dystrophic form of the disease. It is concluded that EBJ enamel is developmentally compromised and that the enamel defects are commensurate with the reported genetic lesions.

Authors+Show Affiliations

Division of Oral Biology, Leeds Dental Institute, Clarendon Way, Leeds, UK. orl.6jen@oralbio.novell.leeds.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

10739859

Citation

Kirkham, J, et al. "The Chemical Composition of Tooth Enamel in Junctional Epidermolysis Bullosa." Archives of Oral Biology, vol. 45, no. 5, 2000, pp. 377-86.
Kirkham J, Robinson C, Strafford SM, et al. The chemical composition of tooth enamel in junctional epidermolysis bullosa. Arch Oral Biol. 2000;45(5):377-86.
Kirkham, J., Robinson, C., Strafford, S. M., Shore, R. C., Bonass, W. A., Brookes, S. J., & Wright, J. T. (2000). The chemical composition of tooth enamel in junctional epidermolysis bullosa. Archives of Oral Biology, 45(5), 377-86.
Kirkham J, et al. The Chemical Composition of Tooth Enamel in Junctional Epidermolysis Bullosa. Arch Oral Biol. 2000;45(5):377-86. PubMed PMID: 10739859.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The chemical composition of tooth enamel in junctional epidermolysis bullosa. AU - Kirkham,J, AU - Robinson,C, AU - Strafford,S M, AU - Shore,R C, AU - Bonass,W A, AU - Brookes,S J, AU - Wright,J T, PY - 2000/3/31/pubmed PY - 2000/6/17/medline PY - 2000/3/31/entrez SP - 377 EP - 86 JF - Archives of oral biology JO - Arch. Oral Biol. VL - 45 IS - 5 N2 - The junctionalis form of epidermolysis bullosa (EBJ) is associated with a number of clinical problems involving tooth enamel, including increased susceptibility to caries. The aim here was to carry out a chemical characterization of the enamel of teeth from EBJ patients compared with that of unaffected controls. The results showed that while protein concentration, amino acid composition and carbonate content were similar in both groups, EBJ enamel contained a significantly reduced mineral per volume content, resulting in enamel hypoplasia. In addition, Western blotting revealed the presence of serum albumin (a known inhibitor of enamel crystal growth) in EBJ enamel. This was not detected in control enamel or in enamel of teeth from patients with the dystrophic form of the disease. It is concluded that EBJ enamel is developmentally compromised and that the enamel defects are commensurate with the reported genetic lesions. SN - 0003-9969 UR - https://www.unboundmedicine.com/medline/citation/10739859/The_chemical_composition_of_tooth_enamel_in_junctional_epidermolysis_bullosa_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-9969(00)00003-0 DB - PRIME DP - Unbound Medicine ER -