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[Detectability of metastatic brain tumors using gadoteridol-enhanced MRI: usefulness of standard-dose T1-weighted spin-echo image with magnetization transfer and enhanced FLAIR].
Nihon Igaku Hoshasen Gakkai Zasshi. 2000 Mar; 60(3):77-82.NI

Abstract

PURPOSE

The aim of this study was to compare the detectability and image contrast of metastatic brain tumors depicted by T1-weighted MR imaging (T1WI) with the magnetization transfer (MT) technique after the administration of a standard dose(MT-SD-T1WI) or T1WI without MT after the administration of a double dose of gadoteridol(DD-T1WI). We also assessed the usefulness of enhanced fluid attenuated inversion recovery (FLAIR) for depicting very small metastatic tumors.

METHODS

Forty-six MRI procedures were performed in 31 patients with metastatic brain tumors that had been diagnosed clinically and radiologically. An incremental dose technique was used with intravenous injections of 0.1 and 0.1 mmol/kg of gadoteridol. In 28 MRI procedures, enhanced FLAIR was carried out after an MT-SD-T1WI study.

RESULTS

Detectability was significantly greater with both MT-SD-T1WI and DD-T1WI than with SD-T1WI. However, there was no significant difference between MT-SD- and DD-T1WI. Although an MT pulse increased the contrast between the enhanced tumor and white matter, the contrast between edema and white matter was decreased. Both MT-SD- and DD-T1WI showed small but conspicuous enhanced foci, but we could not determine whether these were vessels or small metastases on the brain surface. However, enhanced FLAIR only demonstrated foci that were thought to be small metastases.

CONCLUSIONS

MT-SD- and DD-T1WI had equal ability to detect metastatic brain tumors. Enhanced FLAIR was useful for assessing very small metastases on the brain surface.

Authors+Show Affiliations

Department of Radiology, Fukuoka University School of Medicine.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
English Abstract
Journal Article

Language

jpn

PubMed ID

10741113

Citation

Annoura, K, et al. "[Detectability of Metastatic Brain Tumors Using Gadoteridol-enhanced MRI: Usefulness of Standard-dose T1-weighted Spin-echo Image With Magnetization Transfer and Enhanced FLAIR]." Nihon Igaku Hoshasen Gakkai Zasshi. Nippon Acta Radiologica, vol. 60, no. 3, 2000, pp. 77-82.
Annoura K, Utsunomiya H, Arai S, et al. [Detectability of metastatic brain tumors using gadoteridol-enhanced MRI: usefulness of standard-dose T1-weighted spin-echo image with magnetization transfer and enhanced FLAIR]. Nihon Igaku Hoshasen Gakkai Zasshi. 2000;60(3):77-82.
Annoura, K., Utsunomiya, H., Arai, S., & Okazaki, M. (2000). [Detectability of metastatic brain tumors using gadoteridol-enhanced MRI: usefulness of standard-dose T1-weighted spin-echo image with magnetization transfer and enhanced FLAIR]. Nihon Igaku Hoshasen Gakkai Zasshi. Nippon Acta Radiologica, 60(3), 77-82.
Annoura K, et al. [Detectability of Metastatic Brain Tumors Using Gadoteridol-enhanced MRI: Usefulness of Standard-dose T1-weighted Spin-echo Image With Magnetization Transfer and Enhanced FLAIR]. Nihon Igaku Hoshasen Gakkai Zasshi. 2000;60(3):77-82. PubMed PMID: 10741113.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Detectability of metastatic brain tumors using gadoteridol-enhanced MRI: usefulness of standard-dose T1-weighted spin-echo image with magnetization transfer and enhanced FLAIR]. AU - Annoura,K, AU - Utsunomiya,H, AU - Arai,S, AU - Okazaki,M, PY - 2000/3/31/pubmed PY - 2000/6/17/medline PY - 2000/3/31/entrez SP - 77 EP - 82 JF - Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica JO - Nihon Igaku Hoshasen Gakkai Zasshi VL - 60 IS - 3 N2 - PURPOSE: The aim of this study was to compare the detectability and image contrast of metastatic brain tumors depicted by T1-weighted MR imaging (T1WI) with the magnetization transfer (MT) technique after the administration of a standard dose(MT-SD-T1WI) or T1WI without MT after the administration of a double dose of gadoteridol(DD-T1WI). We also assessed the usefulness of enhanced fluid attenuated inversion recovery (FLAIR) for depicting very small metastatic tumors. METHODS: Forty-six MRI procedures were performed in 31 patients with metastatic brain tumors that had been diagnosed clinically and radiologically. An incremental dose technique was used with intravenous injections of 0.1 and 0.1 mmol/kg of gadoteridol. In 28 MRI procedures, enhanced FLAIR was carried out after an MT-SD-T1WI study. RESULTS: Detectability was significantly greater with both MT-SD-T1WI and DD-T1WI than with SD-T1WI. However, there was no significant difference between MT-SD- and DD-T1WI. Although an MT pulse increased the contrast between the enhanced tumor and white matter, the contrast between edema and white matter was decreased. Both MT-SD- and DD-T1WI showed small but conspicuous enhanced foci, but we could not determine whether these were vessels or small metastases on the brain surface. However, enhanced FLAIR only demonstrated foci that were thought to be small metastases. CONCLUSIONS: MT-SD- and DD-T1WI had equal ability to detect metastatic brain tumors. Enhanced FLAIR was useful for assessing very small metastases on the brain surface. SN - 0048-0428 UR - https://www.unboundmedicine.com/medline/citation/10741113/[Detectability_of_metastatic_brain_tumors_using_gadoteridol_enhanced_MRI:_usefulness_of_standard_dose_T1_weighted_spin_echo_image_with_magnetization_transfer_and_enhanced_FLAIR]_ L2 - https://medlineplus.gov/braintumors.html DB - PRIME DP - Unbound Medicine ER -