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Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy.
Nat Med. 2000 Apr; 6(4):405-13.NMed

Abstract

Ischemic peripheral neuropathy is a frequent, irreversible complication of lower extremity vascular insufficiency. We investigated whether ischemic peripheral neuropathy could be prevented and/or reversed by gene transfer of an endothelial cell mitogen designed to promote therapeutic angiogenesis. Intramuscular gene transfer of naked DNA encoding vascular endothelial growth factor (VEGF) simultaneously with induction of hindlimb ischemia in rabbits abrogated the substantial decrease in motor and sensory nerve parameters, and nerve function recovered promptly. When gene transfer was administered 10 days after induction of ischemia, nerve function was restored earlier and/or recovered faster than in untreated rabbits. These findings are due in part to enhanced hindlimb perfusion. In addition, however, the demonstration of functional VEGF receptor expression by Schwann cells indicates a direct effect of VEGF on neural integrity as well. These findings thus constitute a new paradigm for the treatment of ischemic peripheral neuropathy.

Authors+Show Affiliations

Division of Cardiovascular Research St. Elizabeth's Medical Center-Tufts University School of Medicine, 736 Cambridge Street, Boston, Massachusetts 02135, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10742147

Citation

Schratzberger, P, et al. "Favorable Effect of VEGF Gene Transfer On Ischemic Peripheral Neuropathy." Nature Medicine, vol. 6, no. 4, 2000, pp. 405-13.
Schratzberger P, Schratzberger G, Silver M, et al. Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy. Nat Med. 2000;6(4):405-13.
Schratzberger, P., Schratzberger, G., Silver, M., Curry, C., Kearney, M., Magner, M., Alroy, J., Adelman, L. S., Weinberg, D. H., Ropper, A. H., & Isner, J. M. (2000). Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy. Nature Medicine, 6(4), 405-13.
Schratzberger P, et al. Favorable Effect of VEGF Gene Transfer On Ischemic Peripheral Neuropathy. Nat Med. 2000;6(4):405-13. PubMed PMID: 10742147.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy. AU - Schratzberger,P, AU - Schratzberger,G, AU - Silver,M, AU - Curry,C, AU - Kearney,M, AU - Magner,M, AU - Alroy,J, AU - Adelman,L S, AU - Weinberg,D H, AU - Ropper,A H, AU - Isner,J M, PY - 2000/3/31/pubmed PY - 2000/6/17/medline PY - 2000/3/31/entrez SP - 405 EP - 13 JF - Nature medicine JO - Nat. Med. VL - 6 IS - 4 N2 - Ischemic peripheral neuropathy is a frequent, irreversible complication of lower extremity vascular insufficiency. We investigated whether ischemic peripheral neuropathy could be prevented and/or reversed by gene transfer of an endothelial cell mitogen designed to promote therapeutic angiogenesis. Intramuscular gene transfer of naked DNA encoding vascular endothelial growth factor (VEGF) simultaneously with induction of hindlimb ischemia in rabbits abrogated the substantial decrease in motor and sensory nerve parameters, and nerve function recovered promptly. When gene transfer was administered 10 days after induction of ischemia, nerve function was restored earlier and/or recovered faster than in untreated rabbits. These findings are due in part to enhanced hindlimb perfusion. In addition, however, the demonstration of functional VEGF receptor expression by Schwann cells indicates a direct effect of VEGF on neural integrity as well. These findings thus constitute a new paradigm for the treatment of ischemic peripheral neuropathy. SN - 1078-8956 UR - https://www.unboundmedicine.com/medline/citation/10742147/Favorable_effect_of_VEGF_gene_transfer_on_ischemic_peripheral_neuropathy_ L2 - http://dx.doi.org/10.1038/74664 DB - PRIME DP - Unbound Medicine ER -