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Efficacy of influenza vaccination in adult liver transplant recipients.
J Med Virol 2000; 61(1):85-93JM

Abstract

To assess the efficacy of influenza vaccination in immunocompromised adult liver transplant (LTx) recipients, the serum antibody responses of 61 of these patients and 35 liver cirrhosis patients with those of 45 of their healthy spouses were compared, after one and two vaccinations with a commercial trivalent subunit influenza vaccine. In addition, virus-specific proliferative T-cell responses were measured in LTx recipients and their healthy spouses. In all three study groups, significant rises in geometric mean antibody titers were observed for all three antigens after one vaccination. These titers did not continue to increase significantly after the second vaccination in patients with cirrhosis and control subjects but did rise for LTx recipients. The overall antibody response to all three influenza virus strains proved to be significantly lower in the LTx recipients than in the group of healthy subjects after both one and two vaccinations. More than 68% of the LTx recipients developed hemagglutination-inhibiting serum antibody titers >/=40 against all three vaccine strains after the first vaccination and more than 80% after the second vaccination. These findings correlated with the T-cell responses determined for the group of LTx recipients and healthy control individuals. Testing of the respective serum samples against influenza virus A/Sydney/5/97, which circulated in the 1997-1998 influenza season and showed a considerable mismatch with the vaccine strain A/Nanchang/933/95, indicated that such a mismatch may have significant consequences for vaccine efficacy, especially for LTx recipients. Collectively the data show that LTx recipients can be vaccinated effectively against influenza despite immunosuppressive therapy. A two-dose vaccination regimen improved vaccination efficacy in LTx recipients. Whether transplant patients generally benefit from a two-dose vaccination regimen should be evaluated further.

Authors+Show Affiliations

Department of Virology, National Influenza Center, Erasmus Medical Center, Rotterdam, the Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

10745238

Citation

Soesman, N M., et al. "Efficacy of Influenza Vaccination in Adult Liver Transplant Recipients." Journal of Medical Virology, vol. 61, no. 1, 2000, pp. 85-93.
Soesman NM, Rimmelzwaan GF, Nieuwkoop NJ, et al. Efficacy of influenza vaccination in adult liver transplant recipients. J Med Virol. 2000;61(1):85-93.
Soesman, N. M., Rimmelzwaan, G. F., Nieuwkoop, N. J., Beyer, W. E., Tilanus, H. W., Kemmeren, M. H., ... Osterhaus, A. D. (2000). Efficacy of influenza vaccination in adult liver transplant recipients. Journal of Medical Virology, 61(1), pp. 85-93.
Soesman NM, et al. Efficacy of Influenza Vaccination in Adult Liver Transplant Recipients. J Med Virol. 2000;61(1):85-93. PubMed PMID: 10745238.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of influenza vaccination in adult liver transplant recipients. AU - Soesman,N M, AU - Rimmelzwaan,G F, AU - Nieuwkoop,N J, AU - Beyer,W E, AU - Tilanus,H W, AU - Kemmeren,M H, AU - Metselaar,H J, AU - de Man,R A, AU - Osterhaus,A D, PY - 2000/4/4/pubmed PY - 2000/8/1/medline PY - 2000/4/4/entrez SP - 85 EP - 93 JF - Journal of medical virology JO - J. Med. Virol. VL - 61 IS - 1 N2 - To assess the efficacy of influenza vaccination in immunocompromised adult liver transplant (LTx) recipients, the serum antibody responses of 61 of these patients and 35 liver cirrhosis patients with those of 45 of their healthy spouses were compared, after one and two vaccinations with a commercial trivalent subunit influenza vaccine. In addition, virus-specific proliferative T-cell responses were measured in LTx recipients and their healthy spouses. In all three study groups, significant rises in geometric mean antibody titers were observed for all three antigens after one vaccination. These titers did not continue to increase significantly after the second vaccination in patients with cirrhosis and control subjects but did rise for LTx recipients. The overall antibody response to all three influenza virus strains proved to be significantly lower in the LTx recipients than in the group of healthy subjects after both one and two vaccinations. More than 68% of the LTx recipients developed hemagglutination-inhibiting serum antibody titers >/=40 against all three vaccine strains after the first vaccination and more than 80% after the second vaccination. These findings correlated with the T-cell responses determined for the group of LTx recipients and healthy control individuals. Testing of the respective serum samples against influenza virus A/Sydney/5/97, which circulated in the 1997-1998 influenza season and showed a considerable mismatch with the vaccine strain A/Nanchang/933/95, indicated that such a mismatch may have significant consequences for vaccine efficacy, especially for LTx recipients. Collectively the data show that LTx recipients can be vaccinated effectively against influenza despite immunosuppressive therapy. A two-dose vaccination regimen improved vaccination efficacy in LTx recipients. Whether transplant patients generally benefit from a two-dose vaccination regimen should be evaluated further. SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/10745238/Efficacy_of_influenza_vaccination_in_adult_liver_transplant_recipients_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0146-6615&date=2000&volume=61&issue=1&spage=85 DB - PRIME DP - Unbound Medicine ER -