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Effect of 8 week intake of probiotic milk products on risk factors for cardiovascular diseases.

Abstract

OBJECTIVE

To investigate the effect of a probiotic milk product containing the culture CAUSIDO(R) and of two alternative products on risk factors for cardiovascular disease in overweight and obese subjects.

DESIGN

An 8 week randomized, double-blind, placebo- and compliance-controlled, parallel study.

SUBJECTS

Seventy healthy, weight-stable, overweight and obese (25.0<BMI<37.5 kg/m2) males (n=20) and females (n=50), 18-55 y old, were randomly assigned into five groups.

INTERVENTION

Four groups consumed 450 ml fermented milk products (yoghurt) daily. Group 1: a yoghurt fermented with two strains of Streptococcus thermophilus and two strains of Lactobacillus acidophilus (StLa). Group 2: a placebo yoghurt fermented with delta-acid-lactone (PY). Group 3: a yoghurt fermented with two strains of Streptococcus thermophilus and one strain of Lactobacillus rhamnosus (StLr). Group 4: a yoghurt fermented with one strain of Enterococcus faecium and two strains of Streptococcus thermophilus (CAUSIDO(R) culture), GAIO(R) (G). The dietary composition of the yoghurt was otherwise similar. The fifth group was given two placebo pills (PP) daily.

RESULTS

When comparing all five treatment groups, unadjusted for changes in body weight, no statistical effects were observed in week 8 in the G-group on low density lipoproteins (LDL)-cholesterol (P=0.29). After adjustment for small changes in body weight, LDL-cholesterol decreased by 8.4% (0.26+/-0.10 mmol/l; P<0.05) and fibrinogen increased (0.74+/-0.32 mmol/l; P<0.05) after 8 weeks in the G-group. This was significantly different from the group consuming chemically fermented yoghurt and the group consuming placebo pills (P<0.05). After 8 weeks, systolic blood pressure was significantly more reduced in the StLa and G-group compared to StLr. No other differences were found.

CONCLUSION

The CAUSIDO(R) culture reduced LDL-cholesterol and increased fibrinogen in the overweight subjects at a 450 ml consumption daily for 8 weeks. The effect on LDL-cholesterol confirms previous studies. An immunostimulation by one of the strains in the product might explain the effect on fibrinogen in the G-group.

SPONSORSHIP

MD Foods A/S, Denmark.

Authors+Show Affiliations

,

Research Department of Human Nutrition, Centre for Food Research, The Royal Veterinary and Agricultural University, DK-1958 Frederiksberg C, Denmark. lil@kvl.dk

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Source

MeSH

Adult
Analysis of Variance
Blood Pressure
Body Weight
Cardiovascular Diseases
Cholesterol, LDL
Double-Blind Method
Female
Fibrinogen
Humans
Intestinal Absorption
Lactobacillus acidophilus
Male
Middle Aged
Obesity
Patient Compliance
Probiotics
Risk Factors
Yogurt

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10745279

Citation

Agerholm-Larsen, L, et al. "Effect of 8 Week Intake of Probiotic Milk Products On Risk Factors for Cardiovascular Diseases." European Journal of Clinical Nutrition, vol. 54, no. 4, 2000, pp. 288-97.
Agerholm-Larsen L, Raben A, Haulrik N, et al. Effect of 8 week intake of probiotic milk products on risk factors for cardiovascular diseases. Eur J Clin Nutr. 2000;54(4):288-97.
Agerholm-Larsen, L., Raben, A., Haulrik, N., Hansen, A. S., Manders, M., & Astrup, A. (2000). Effect of 8 week intake of probiotic milk products on risk factors for cardiovascular diseases. European Journal of Clinical Nutrition, 54(4), pp. 288-97.
Agerholm-Larsen L, et al. Effect of 8 Week Intake of Probiotic Milk Products On Risk Factors for Cardiovascular Diseases. Eur J Clin Nutr. 2000;54(4):288-97. PubMed PMID: 10745279.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of 8 week intake of probiotic milk products on risk factors for cardiovascular diseases. AU - Agerholm-Larsen,L, AU - Raben,A, AU - Haulrik,N, AU - Hansen,A S, AU - Manders,M, AU - Astrup,A, PY - 2000/4/4/pubmed PY - 2000/5/20/medline PY - 2000/4/4/entrez SP - 288 EP - 97 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 54 IS - 4 N2 - OBJECTIVE: To investigate the effect of a probiotic milk product containing the culture CAUSIDO(R) and of two alternative products on risk factors for cardiovascular disease in overweight and obese subjects. DESIGN: An 8 week randomized, double-blind, placebo- and compliance-controlled, parallel study. SUBJECTS: Seventy healthy, weight-stable, overweight and obese (25.0<BMI<37.5 kg/m2) males (n=20) and females (n=50), 18-55 y old, were randomly assigned into five groups. INTERVENTION: Four groups consumed 450 ml fermented milk products (yoghurt) daily. Group 1: a yoghurt fermented with two strains of Streptococcus thermophilus and two strains of Lactobacillus acidophilus (StLa). Group 2: a placebo yoghurt fermented with delta-acid-lactone (PY). Group 3: a yoghurt fermented with two strains of Streptococcus thermophilus and one strain of Lactobacillus rhamnosus (StLr). Group 4: a yoghurt fermented with one strain of Enterococcus faecium and two strains of Streptococcus thermophilus (CAUSIDO(R) culture), GAIO(R) (G). The dietary composition of the yoghurt was otherwise similar. The fifth group was given two placebo pills (PP) daily. RESULTS: When comparing all five treatment groups, unadjusted for changes in body weight, no statistical effects were observed in week 8 in the G-group on low density lipoproteins (LDL)-cholesterol (P=0.29). After adjustment for small changes in body weight, LDL-cholesterol decreased by 8.4% (0.26+/-0.10 mmol/l; P<0.05) and fibrinogen increased (0.74+/-0.32 mmol/l; P<0.05) after 8 weeks in the G-group. This was significantly different from the group consuming chemically fermented yoghurt and the group consuming placebo pills (P<0.05). After 8 weeks, systolic blood pressure was significantly more reduced in the StLa and G-group compared to StLr. No other differences were found. CONCLUSION: The CAUSIDO(R) culture reduced LDL-cholesterol and increased fibrinogen in the overweight subjects at a 450 ml consumption daily for 8 weeks. The effect on LDL-cholesterol confirms previous studies. An immunostimulation by one of the strains in the product might explain the effect on fibrinogen in the G-group. SPONSORSHIP: MD Foods A/S, Denmark. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/10745279/Effect_of_8_week_intake_of_probiotic_milk_products_on_risk_factors_for_cardiovascular_diseases_ L2 - https://medlineplus.gov/obesity.html DB - PRIME DP - Unbound Medicine ER -