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A Drosophila model of Parkinson's disease.
Nature. 2000 Mar 23; 404(6776):394-8.Nat

Abstract

Parkinson's disease is a common neurodegenerative syndrome characterized by loss of dopaminergic neurons in the substantia nigra, formation of filamentous intraneuronal inclusions (Lewy bodies) and an extrapyramidal movement disorder. Mutations in the alpha-synuclein gene are linked to familial Parkinson's disease and alpha-synuclein accumulates in Lewy bodies and Lewy neurites. Here we express normal and mutant forms of alpha-synuclein in Drosophila and produce adult-onset loss of dopaminergic neurons, filamentous intraneuronal inclusions containing alpha-synuclein and locomotor dysfunction. Our Drosophila model thus recapitulates the essential features of the human disorder, and makes possible a powerful genetic approach to Parkinson's disease.

Authors+Show Affiliations

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. mel_feany@hms.harvard.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10746727

Citation

Feany, M B., and W W. Bender. "A Drosophila Model of Parkinson's Disease." Nature, vol. 404, no. 6776, 2000, pp. 394-8.
Feany MB, Bender WW. A Drosophila model of Parkinson's disease. Nature. 2000;404(6776):394-8.
Feany, M. B., & Bender, W. W. (2000). A Drosophila model of Parkinson's disease. Nature, 404(6776), 394-8.
Feany MB, Bender WW. A Drosophila Model of Parkinson's Disease. Nature. 2000 Mar 23;404(6776):394-8. PubMed PMID: 10746727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Drosophila model of Parkinson's disease. AU - Feany,M B, AU - Bender,W W, PY - 2000/02/14/received PY - 2000/03/02/accepted PY - 2000/4/4/pubmed PY - 2000/4/15/medline PY - 2000/4/4/entrez SP - 394 EP - 8 JF - Nature JO - Nature VL - 404 IS - 6776 N2 - Parkinson's disease is a common neurodegenerative syndrome characterized by loss of dopaminergic neurons in the substantia nigra, formation of filamentous intraneuronal inclusions (Lewy bodies) and an extrapyramidal movement disorder. Mutations in the alpha-synuclein gene are linked to familial Parkinson's disease and alpha-synuclein accumulates in Lewy bodies and Lewy neurites. Here we express normal and mutant forms of alpha-synuclein in Drosophila and produce adult-onset loss of dopaminergic neurons, filamentous intraneuronal inclusions containing alpha-synuclein and locomotor dysfunction. Our Drosophila model thus recapitulates the essential features of the human disorder, and makes possible a powerful genetic approach to Parkinson's disease. SN - 0028-0836 UR - https://www.unboundmedicine.com/medline/citation/10746727/A_Drosophila_model_of_Parkinson's_disease_ L2 - https://doi.org/10.1038/35006074 DB - PRIME DP - Unbound Medicine ER -