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Systemic estrogens have no conclusive beneficial effect on human skin connective tissue.
Acta Obstet Gynecol Scand. 2000 Apr; 79(4):250-4.AO

Abstract

SUBJECT

Aging of the skin is affected by intrinsic and extrinsic factors. Especially important extrinsic factor is ultraviolet radiation, which causes premature aging of the skin. Intrinsic aging is influenced by genetic factors, and changes in hormones. In menopause, changes in hormonal balance have been suggested to enhance aging of the skin.

DISCUSSION

Accordingly, several studies have been accomplished, in which hormone replacement therapy (HRT) has been used in order to prevent skin aging at or after the menopause. In this overview the results of previous studies, and a study done recently, are critically reviewed.

CONCLUSION

One year systemic replacement therapy has no beneficial effect on the skin thickness, collagen synthesis, or elastin. Topical estrogens might have some beneficial effects. However, since the number of patients treated with topical estrogens is relatively small, further studies are needed.

Authors+Show Affiliations

Department of Dermatology, University of Oulu and Oulu University Hospital, Finland.

Pub Type(s)

Comment
Journal Article

Language

eng

PubMed ID

10746837

Citation

Oikarinen, A. "Systemic Estrogens Have No Conclusive Beneficial Effect On Human Skin Connective Tissue." Acta Obstetricia Et Gynecologica Scandinavica, vol. 79, no. 4, 2000, pp. 250-4.
Oikarinen A. Systemic estrogens have no conclusive beneficial effect on human skin connective tissue. Acta Obstet Gynecol Scand. 2000;79(4):250-4.
Oikarinen, A. (2000). Systemic estrogens have no conclusive beneficial effect on human skin connective tissue. Acta Obstetricia Et Gynecologica Scandinavica, 79(4), 250-4.
Oikarinen A. Systemic Estrogens Have No Conclusive Beneficial Effect On Human Skin Connective Tissue. Acta Obstet Gynecol Scand. 2000;79(4):250-4. PubMed PMID: 10746837.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Systemic estrogens have no conclusive beneficial effect on human skin connective tissue. A1 - Oikarinen,A, PY - 2000/4/4/pubmed PY - 2000/4/25/medline PY - 2000/4/4/entrez SP - 250 EP - 4 JF - Acta obstetricia et gynecologica Scandinavica JO - Acta Obstet Gynecol Scand VL - 79 IS - 4 N2 - SUBJECT: Aging of the skin is affected by intrinsic and extrinsic factors. Especially important extrinsic factor is ultraviolet radiation, which causes premature aging of the skin. Intrinsic aging is influenced by genetic factors, and changes in hormones. In menopause, changes in hormonal balance have been suggested to enhance aging of the skin. DISCUSSION: Accordingly, several studies have been accomplished, in which hormone replacement therapy (HRT) has been used in order to prevent skin aging at or after the menopause. In this overview the results of previous studies, and a study done recently, are critically reviewed. CONCLUSION: One year systemic replacement therapy has no beneficial effect on the skin thickness, collagen synthesis, or elastin. Topical estrogens might have some beneficial effects. However, since the number of patients treated with topical estrogens is relatively small, further studies are needed. SN - 0001-6349 UR - https://www.unboundmedicine.com/medline/citation/10746837/Systemic_estrogens_have_no_conclusive_beneficial_effect_on_human_skin_connective_tissue_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=10746837.ui DB - PRIME DP - Unbound Medicine ER -