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Viscoelastic properties of normal and atherosclerotic carotid arteries.
Eur J Vasc Endovasc Surg 2000; 19(3):221-5EJ

Abstract

BACKGROUND

remodelling of the arterial wall occurs with ageing, even in the absence of atherosclerotic risk factors. With increasing age, arteries dilate, thicken, and get stiffer. The aim of this study was to correlate carotid artery stiffness with wall thickness and plaque presence between healthy individuals and patients with early and advanced atherosclerosis.

METHODS

twenty healthy volunteers, 40 carotid segments and 90 patients, 174 carotid segments, with vascular disease were included in the study. The carotid artery was imaged longitudinally and measurements of the intimal-medial thickness (IMT) and plaque were obtained. Systolic and diastolic blood pressures were taken from each arm. The carotid artery stiffness (pressure-strain elastic modulus, Ep) was calculated in all sites from the changes in pressure and diameter. M-mode was used to detect the diameter change (systolic to diastolic) over five cardiac cycles.

RESULTS

in the healthy volunteers there was no evidence of plaque or increased IMT. The mean IMT was significantly higher in the patients compared to control (0.83+/-0.27 mm vs. 0.54+/-0.08 mm, p <0.0001). The IMT had a poor correlation with Ep at lower thickness (r=0.24, p=0.08) but this association became stronger with increasing thickness (r=0.62, p<0.001). Arterial segments with an IMT 5 0.88 mm became significantly stiffer compared to the controls (p<0.001) and to patients with an IMT<0.88 mm (p <0.01). Carotid Ep was markedly greater in arterial segments with plaques than in those with increased IMT (p <0.001) and the controls (p<0.0001).

CONCLUSIONS

carotid wall areas with small increase in IMT have a poor correlation with carotid artery stiffness. The carotid stiffness increases in areas with marked wall thickening and particularly in segments with plaque. The simultaneous study of vessel-wall elastic behaviour with IMT and plaque changes may increase our understanding of atherosclerotic progression and wall remodelling.

Authors+Show Affiliations

Department of Surgery, Loyola University Medical Center, Maywood, IL 60153-3304, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

10753683

Citation

Labropoulos, N, et al. "Viscoelastic Properties of Normal and Atherosclerotic Carotid Arteries." European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, vol. 19, no. 3, 2000, pp. 221-5.
Labropoulos N, Ashraf Mansour M, Kang SS, et al. Viscoelastic properties of normal and atherosclerotic carotid arteries. Eur J Vasc Endovasc Surg. 2000;19(3):221-5.
Labropoulos, N., Ashraf Mansour, M., Kang, S. S., Oh, D. S., Buckman, J., & Baker, W. H. (2000). Viscoelastic properties of normal and atherosclerotic carotid arteries. European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, 19(3), pp. 221-5.
Labropoulos N, et al. Viscoelastic Properties of Normal and Atherosclerotic Carotid Arteries. Eur J Vasc Endovasc Surg. 2000;19(3):221-5. PubMed PMID: 10753683.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Viscoelastic properties of normal and atherosclerotic carotid arteries. AU - Labropoulos,N, AU - Ashraf Mansour,M, AU - Kang,S S, AU - Oh,D S, AU - Buckman,J, AU - Baker,W H, PY - 2001/2/7/pubmed PY - 2001/2/7/medline PY - 2001/2/7/entrez SP - 221 EP - 5 JF - European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery JO - Eur J Vasc Endovasc Surg VL - 19 IS - 3 N2 - BACKGROUND: remodelling of the arterial wall occurs with ageing, even in the absence of atherosclerotic risk factors. With increasing age, arteries dilate, thicken, and get stiffer. The aim of this study was to correlate carotid artery stiffness with wall thickness and plaque presence between healthy individuals and patients with early and advanced atherosclerosis. METHODS: twenty healthy volunteers, 40 carotid segments and 90 patients, 174 carotid segments, with vascular disease were included in the study. The carotid artery was imaged longitudinally and measurements of the intimal-medial thickness (IMT) and plaque were obtained. Systolic and diastolic blood pressures were taken from each arm. The carotid artery stiffness (pressure-strain elastic modulus, Ep) was calculated in all sites from the changes in pressure and diameter. M-mode was used to detect the diameter change (systolic to diastolic) over five cardiac cycles. RESULTS: in the healthy volunteers there was no evidence of plaque or increased IMT. The mean IMT was significantly higher in the patients compared to control (0.83+/-0.27 mm vs. 0.54+/-0.08 mm, p <0.0001). The IMT had a poor correlation with Ep at lower thickness (r=0.24, p=0.08) but this association became stronger with increasing thickness (r=0.62, p<0.001). Arterial segments with an IMT 5 0.88 mm became significantly stiffer compared to the controls (p<0.001) and to patients with an IMT<0.88 mm (p <0.01). Carotid Ep was markedly greater in arterial segments with plaques than in those with increased IMT (p <0.001) and the controls (p<0.0001). CONCLUSIONS: carotid wall areas with small increase in IMT have a poor correlation with carotid artery stiffness. The carotid stiffness increases in areas with marked wall thickening and particularly in segments with plaque. The simultaneous study of vessel-wall elastic behaviour with IMT and plaque changes may increase our understanding of atherosclerotic progression and wall remodelling. SN - 1078-5884 UR - https://www.unboundmedicine.com/medline/citation/10753683/Viscoelastic_properties_of_normal_and_atherosclerotic_carotid_arteries_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1078588499910080 DB - PRIME DP - Unbound Medicine ER -