Tags

Type your tag names separated by a space and hit enter

Randomized controlled trial of doxycycline prophylaxis against leptospirosis in an endemic area.
Int J Antimicrob Agents. 2000 Feb; 13(4):249-55.IJ

Abstract

Leptospirosis occurs as seasonal outbreaks, lasting for about 3 weeks during October-November in North Andaman. A randomized controlled trial was undertaken to assess the efficacy of doxycycline prophylaxis in the prevention of infection and clinical disease due to leptospires during the outbreak period. A sample population of 782 persons, randomized into two groups was given doxycycline 200 mg/week and a placebo. The microscopic agglutination test was done on blood samples collected on day zero, after 6 weeks and after 12 weeks. Infection rates and attack rates of clinical illness were calculated in the two groups based on the serological results. Statistically there was no difference in the infection rates among the two groups. However, a statistically significant difference was observed in the clinical disease attack rates (3.11 vs. 6.82%) between study group and control group. The results of the study indicate that doxycycline prophylaxis does not prevent leptospiral infection in an endemic area, but has a significant protective effect in reducing the morbidity and mortality during outbreaks.

Authors+Show Affiliations

Regional Medical Research Centre (Indian Council of Medical Research), Port Blair, Andaman and Nicobar Islands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

10755239

Citation

Sehgal, S C., et al. "Randomized Controlled Trial of Doxycycline Prophylaxis Against Leptospirosis in an Endemic Area." International Journal of Antimicrobial Agents, vol. 13, no. 4, 2000, pp. 249-55.
Sehgal SC, Sugunan AP, Murhekar MV, et al. Randomized controlled trial of doxycycline prophylaxis against leptospirosis in an endemic area. Int J Antimicrob Agents. 2000;13(4):249-55.
Sehgal, S. C., Sugunan, A. P., Murhekar, M. V., Sharma, S., & Vijayachari, P. (2000). Randomized controlled trial of doxycycline prophylaxis against leptospirosis in an endemic area. International Journal of Antimicrobial Agents, 13(4), 249-55.
Sehgal SC, et al. Randomized Controlled Trial of Doxycycline Prophylaxis Against Leptospirosis in an Endemic Area. Int J Antimicrob Agents. 2000;13(4):249-55. PubMed PMID: 10755239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Randomized controlled trial of doxycycline prophylaxis against leptospirosis in an endemic area. AU - Sehgal,S C, AU - Sugunan,A P, AU - Murhekar,M V, AU - Sharma,S, AU - Vijayachari,P, PY - 2000/4/8/pubmed PY - 2000/6/10/medline PY - 2000/4/8/entrez SP - 249 EP - 55 JF - International journal of antimicrobial agents JO - Int J Antimicrob Agents VL - 13 IS - 4 N2 - Leptospirosis occurs as seasonal outbreaks, lasting for about 3 weeks during October-November in North Andaman. A randomized controlled trial was undertaken to assess the efficacy of doxycycline prophylaxis in the prevention of infection and clinical disease due to leptospires during the outbreak period. A sample population of 782 persons, randomized into two groups was given doxycycline 200 mg/week and a placebo. The microscopic agglutination test was done on blood samples collected on day zero, after 6 weeks and after 12 weeks. Infection rates and attack rates of clinical illness were calculated in the two groups based on the serological results. Statistically there was no difference in the infection rates among the two groups. However, a statistically significant difference was observed in the clinical disease attack rates (3.11 vs. 6.82%) between study group and control group. The results of the study indicate that doxycycline prophylaxis does not prevent leptospiral infection in an endemic area, but has a significant protective effect in reducing the morbidity and mortality during outbreaks. SN - 0924-8579 UR - https://www.unboundmedicine.com/medline/citation/10755239/Randomized_controlled_trial_of_doxycycline_prophylaxis_against_leptospirosis_in_an_endemic_area_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S092485799900134X DB - PRIME DP - Unbound Medicine ER -