Tags

Type your tag names separated by a space and hit enter

Pathophysiology of levodopa-induced dyskinesias in Parkinson's disease: problems with the current model.
Ann Neurol. 2000 Apr; 47(4 Suppl 1):S22-32; discussion S32-4.AN

Abstract

The anatomical and physiological basis of levodopa-induced dyskinesias (LIDs) in patients with Parkinson's disease (PD) is reviewed in the light of the current model for the organization of the basal ganglia. This model, which was developed in the late 1980s, works relatively well in explaining the motor features of PD but, for example, it does not account for why tremor, rigidity, bradykinesia, gait dysfunction and postural instability present to differing degrees in different patients, and may respond differently to levodopa treatment or surgical procedures. Recent information suggests that LIDs develop as a consequence of pulsatile stimulation of dopamine receptors, with consequent dysregulation of genes and proteins in downstream neurons resulting in changes in neuronal firing patterns. A modified model of the basal ganglia in PD patients with LID is proposed, which incorporates more recent clinical and experimental data.

Links

Publisher Full Text

Authors+Show Affiliations

Obeso JA
Department of Neurology and Neurosurgery, Clínica Universitaria and Medical School, University of Navarra, Pamplona, Spain.
Rodriguez-Oroz MC
No affiliation info available
Rodriguez M
No affiliation info available
DeLong MR
No affiliation info available
Olanow CW
No affiliation info available

MeSH

Basal GangliaBrain ChemistryDopamine AgentsDyskinesia, Drug-InducedHumansLevodopaParkinson Disease

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

10762129

Clinical Trial Links

Preventing Levodopa Induced Dyskinesia in Parkinson's Disease With HMG-CoA Reductase Inhibitors

Citation

Obeso, J A., et al. "Pathophysiology of Levodopa-induced Dyskinesias in Parkinson's Disease: Problems With the Current Model." Annals of Neurology, vol. 47, no. 4 Suppl 1, 2000, pp. S22-32; discussion S32-4.
Obeso JA, Rodriguez-Oroz MC, Rodriguez M, et al. Pathophysiology of levodopa-induced dyskinesias in Parkinson's disease: problems with the current model. Ann Neurol. 2000;47(4 Suppl 1):S22-32; discussion S32-4.
Obeso, J. A., Rodriguez-Oroz, M. C., Rodriguez, M., DeLong, M. R., & Olanow, C. W. (2000). Pathophysiology of levodopa-induced dyskinesias in Parkinson's disease: problems with the current model. Annals of Neurology, 47(4 Suppl 1), S22-32; discussion S32-4.
Obeso JA, et al. Pathophysiology of Levodopa-induced Dyskinesias in Parkinson's Disease: Problems With the Current Model. Ann Neurol. 2000;47(4 Suppl 1):S22-32; discussion S32-4. PubMed PMID: 10762129.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathophysiology of levodopa-induced dyskinesias in Parkinson's disease: problems with the current model. AU - Obeso,J A, AU - Rodriguez-Oroz,M C, AU - Rodriguez,M, AU - DeLong,M R, AU - Olanow,C W, PY - 2000/4/13/pubmed PY - 2000/4/29/medline PY - 2000/4/13/entrez SP - S22-32; discussion S32-4 JF - Annals of neurology JO - Ann Neurol VL - 47 IS - 4 Suppl 1 N2 - The anatomical and physiological basis of levodopa-induced dyskinesias (LIDs) in patients with Parkinson's disease (PD) is reviewed in the light of the current model for the organization of the basal ganglia. This model, which was developed in the late 1980s, works relatively well in explaining the motor features of PD but, for example, it does not account for why tremor, rigidity, bradykinesia, gait dysfunction and postural instability present to differing degrees in different patients, and may respond differently to levodopa treatment or surgical procedures. Recent information suggests that LIDs develop as a consequence of pulsatile stimulation of dopamine receptors, with consequent dysregulation of genes and proteins in downstream neurons resulting in changes in neuronal firing patterns. A modified model of the basal ganglia in PD patients with LID is proposed, which incorporates more recent clinical and experimental data. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/10762129/Pathophysiology_of_levodopa_induced_dyskinesias_in_Parkinson's_disease:_problems_with_the_current_model_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=2000&volume=47&issue=4 Suppl 1&spage=S22 DB - PRIME DP - Unbound Medicine ER -