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Dyskinesias and the subthalamic nucleus.
Ann Neurol. 2000 Apr; 47(4 Suppl 1):S189-92.AN

Abstract

Severe dyskinesias or ballism can occur following hemorrhagic events in the subthalamic nucleus (STN), and it has recently been established that the STN plays a major role in the pathophysiology of the motor dysfunction of Parkinson's disease (PD) and that STN inhibition improves parkinsonian dysfunction. Deep brain stimulation of the STN in PD patients is therefore currently being evaluated as a therapy. High-frequency stimulation of the STN in PD patients can induce intense dyskinesias that are similar to those induced by levodopa. These may occur with a variable latency and resemble all types of levodopa-induced dyskinesias (LIDs). They can be decreased by reducing the levodopa dosage, which is permitted by the antiparkinsonian effect of stimulating the STN. STN stimulation has been shown to improve all types of LIDs, with the most dramatic effect being that on off-period dystonia. The improvement in LIDs may relate to the decrease in drug dosage, while the off-period dystonia is likely improved by the simultaneous administration of levodopa and STN stimulation. It is thought that the STN is an important node in a network, which can produce dyskinesias when disturbed by a lesion, and is particularly sensitive for the induction of these abnormal movements.

Authors+Show Affiliations

Department of Clinical and Biological Neurosciences, INSERM Preclinical Neurobiology U-318, Joseph Fourier University of Grenoble, Hôpital A. Michallon, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10762147

Citation

Benabid, A L., et al. "Dyskinesias and the Subthalamic Nucleus." Annals of Neurology, vol. 47, no. 4 Suppl 1, 2000, pp. S189-92.
Benabid AL, Benazzouz A, Limousin P, et al. Dyskinesias and the subthalamic nucleus. Ann Neurol. 2000;47(4 Suppl 1):S189-92.
Benabid, A. L., Benazzouz, A., Limousin, P., Koudsie, A., Krack, P., Piallat, B., & Pollak, P. (2000). Dyskinesias and the subthalamic nucleus. Annals of Neurology, 47(4 Suppl 1), S189-92.
Benabid AL, et al. Dyskinesias and the Subthalamic Nucleus. Ann Neurol. 2000;47(4 Suppl 1):S189-92. PubMed PMID: 10762147.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dyskinesias and the subthalamic nucleus. AU - Benabid,A L, AU - Benazzouz,A, AU - Limousin,P, AU - Koudsie,A, AU - Krack,P, AU - Piallat,B, AU - Pollak,P, PY - 2000/4/13/pubmed PY - 2000/4/29/medline PY - 2000/4/13/entrez SP - S189 EP - 92 JF - Annals of neurology JO - Ann Neurol VL - 47 IS - 4 Suppl 1 N2 - Severe dyskinesias or ballism can occur following hemorrhagic events in the subthalamic nucleus (STN), and it has recently been established that the STN plays a major role in the pathophysiology of the motor dysfunction of Parkinson's disease (PD) and that STN inhibition improves parkinsonian dysfunction. Deep brain stimulation of the STN in PD patients is therefore currently being evaluated as a therapy. High-frequency stimulation of the STN in PD patients can induce intense dyskinesias that are similar to those induced by levodopa. These may occur with a variable latency and resemble all types of levodopa-induced dyskinesias (LIDs). They can be decreased by reducing the levodopa dosage, which is permitted by the antiparkinsonian effect of stimulating the STN. STN stimulation has been shown to improve all types of LIDs, with the most dramatic effect being that on off-period dystonia. The improvement in LIDs may relate to the decrease in drug dosage, while the off-period dystonia is likely improved by the simultaneous administration of levodopa and STN stimulation. It is thought that the STN is an important node in a network, which can produce dyskinesias when disturbed by a lesion, and is particularly sensitive for the induction of these abnormal movements. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/10762147/Dyskinesias_and_the_subthalamic_nucleus_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=2000&volume=47&issue=4 Suppl 1&spage=S189 DB - PRIME DP - Unbound Medicine ER -