Tags

Type your tag names separated by a space and hit enter

Surgery for levodopa-induced dyskinesias.
Ann Neurol. 2000 Apr; 47(4 Suppl 1):S193-9; discussion S199-202.AN

Abstract

The effects of surgical interventions for levodopa-induced dyskinesias (LIDs) in Parkinson's disease are reviewed. Since the introduction of levodopa, thalamotomy has been reported to have variable effects on LIDs. Striking benefit has been demonstrated, and efficacy is probably dependent on the size and location of the lesion. However, it remains unclear whether it is an effective treatment for all types of LIDs. Currently, pallidotomy is probably the most reliable and effective surgical treatment for LIDs, and will continue to play an important role in its management until other treatments become more widely available. Deep brain stimulation is an extremely exciting mode of therapy, particularly in the subthalamic nucleus and the globus pallidus, and early results of its use in the treatment of LIDs are promising. The effects of cerebral transplantation, still an experimental technique, on LIDs are inconsistent and controversial, and there is little reliable evidence that gamma knife radiosurgery can be safely applied to parkinsonian patients for the treatment of LIDs.

Authors+Show Affiliations

Toronto Western Hospital, Division of Neurology, Morton & Gloria Shulman Movement Disorders Clinic, and the University of Toronto, Ontario, Canada.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10762148

Citation

Lang, A E.. "Surgery for Levodopa-induced Dyskinesias." Annals of Neurology, vol. 47, no. 4 Suppl 1, 2000, pp. S193-9; discussion S199-202.
Lang AE. Surgery for levodopa-induced dyskinesias. Ann Neurol. 2000;47(4 Suppl 1):S193-9; discussion S199-202.
Lang, A. E. (2000). Surgery for levodopa-induced dyskinesias. Annals of Neurology, 47(4 Suppl 1), S193-9; discussion S199-202.
Lang AE. Surgery for Levodopa-induced Dyskinesias. Ann Neurol. 2000;47(4 Suppl 1):S193-9; discussion S199-202. PubMed PMID: 10762148.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Surgery for levodopa-induced dyskinesias. A1 - Lang,A E, PY - 2000/4/13/pubmed PY - 2000/4/29/medline PY - 2000/4/13/entrez SP - S193-9; discussion S199-202 JF - Annals of neurology JO - Ann Neurol VL - 47 IS - 4 Suppl 1 N2 - The effects of surgical interventions for levodopa-induced dyskinesias (LIDs) in Parkinson's disease are reviewed. Since the introduction of levodopa, thalamotomy has been reported to have variable effects on LIDs. Striking benefit has been demonstrated, and efficacy is probably dependent on the size and location of the lesion. However, it remains unclear whether it is an effective treatment for all types of LIDs. Currently, pallidotomy is probably the most reliable and effective surgical treatment for LIDs, and will continue to play an important role in its management until other treatments become more widely available. Deep brain stimulation is an extremely exciting mode of therapy, particularly in the subthalamic nucleus and the globus pallidus, and early results of its use in the treatment of LIDs are promising. The effects of cerebral transplantation, still an experimental technique, on LIDs are inconsistent and controversial, and there is little reliable evidence that gamma knife radiosurgery can be safely applied to parkinsonian patients for the treatment of LIDs. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/10762148/Surgery_for_levodopa_induced_dyskinesias_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=2000&volume=47&issue=4 Suppl 1&spage=S193 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.