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Synphilin-1 is present in Lewy bodies in Parkinson's disease.
Ann Neurol. 2000 Apr; 47(4):521-3.AN

Abstract

Alpha-synuclein is believed to play an important role in Parkinson's disease (PD). Mutations in the alpha-synuclein gene are responsible for familial forms of PD and alpha-synuclein protein is a major component of Lewy bodies in patients with sporadic PD. Synphilin-1 is a novel protein that we have previously found to associate in vivo with alpha-synuclein. We now show that synphilin-1 is present in Lewy bodies of patients with PD. Our data suggest that synphilin-1 could play a role in Lewy body formation and the pathogenesis of PD.

Authors+Show Affiliations

Brain Disease Research Center, Brain Research Institute, Niigata University, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10762166

Citation

Wakabayashi, K, et al. "Synphilin-1 Is Present in Lewy Bodies in Parkinson's Disease." Annals of Neurology, vol. 47, no. 4, 2000, pp. 521-3.
Wakabayashi K, Engelender S, Yoshimoto M, et al. Synphilin-1 is present in Lewy bodies in Parkinson's disease. Ann Neurol. 2000;47(4):521-3.
Wakabayashi, K., Engelender, S., Yoshimoto, M., Tsuji, S., Ross, C. A., & Takahashi, H. (2000). Synphilin-1 is present in Lewy bodies in Parkinson's disease. Annals of Neurology, 47(4), 521-3.
Wakabayashi K, et al. Synphilin-1 Is Present in Lewy Bodies in Parkinson's Disease. Ann Neurol. 2000;47(4):521-3. PubMed PMID: 10762166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synphilin-1 is present in Lewy bodies in Parkinson's disease. AU - Wakabayashi,K, AU - Engelender,S, AU - Yoshimoto,M, AU - Tsuji,S, AU - Ross,C A, AU - Takahashi,H, PY - 2000/4/13/pubmed PY - 2000/4/29/medline PY - 2000/4/13/entrez SP - 521 EP - 3 JF - Annals of neurology JO - Ann Neurol VL - 47 IS - 4 N2 - Alpha-synuclein is believed to play an important role in Parkinson's disease (PD). Mutations in the alpha-synuclein gene are responsible for familial forms of PD and alpha-synuclein protein is a major component of Lewy bodies in patients with sporadic PD. Synphilin-1 is a novel protein that we have previously found to associate in vivo with alpha-synuclein. We now show that synphilin-1 is present in Lewy bodies of patients with PD. Our data suggest that synphilin-1 could play a role in Lewy body formation and the pathogenesis of PD. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/10762166/Synphilin_1_is_present_in_Lewy_bodies_in_Parkinson's_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=2000&volume=47&issue=4&spage=521 DB - PRIME DP - Unbound Medicine ER -