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Synphilin-1 is present in Lewy bodies in Parkinson's disease.
Ann Neurol. 2000 Apr; 47(4):521-3.AN

Abstract

Alpha-synuclein is believed to play an important role in Parkinson's disease (PD). Mutations in the alpha-synuclein gene are responsible for familial forms of PD and alpha-synuclein protein is a major component of Lewy bodies in patients with sporadic PD. Synphilin-1 is a novel protein that we have previously found to associate in vivo with alpha-synuclein. We now show that synphilin-1 is present in Lewy bodies of patients with PD. Our data suggest that synphilin-1 could play a role in Lewy body formation and the pathogenesis of PD.

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Authors+Show Affiliations

Wakabayashi K
Brain Disease Research Center, Brain Research Institute, Niigata University, Japan.
Engelender S
No affiliation info available
Yoshimoto M
No affiliation info available
Tsuji S
No affiliation info available
Ross CA
No affiliation info available
Takahashi H
No affiliation info available

MeSH

AgedAged, 80 and overAnimalsAntibodiesBlotting, WesternCarrier ProteinsHumansLewy BodiesMiddle AgedNerve Tissue ProteinsNeuronsParkinson DiseaseRabbitsSubstantia NigraSynucleinsalpha-Synuclein

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10762166

Citation

Wakabayashi, K, et al. "Synphilin-1 Is Present in Lewy Bodies in Parkinson's Disease." Annals of Neurology, vol. 47, no. 4, 2000, pp. 521-3.
Wakabayashi K, Engelender S, Yoshimoto M, et al. Synphilin-1 is present in Lewy bodies in Parkinson's disease. Ann Neurol. 2000;47(4):521-3.
Wakabayashi, K., Engelender, S., Yoshimoto, M., Tsuji, S., Ross, C. A., & Takahashi, H. (2000). Synphilin-1 is present in Lewy bodies in Parkinson's disease. Annals of Neurology, 47(4), 521-3.
Wakabayashi K, et al. Synphilin-1 Is Present in Lewy Bodies in Parkinson's Disease. Ann Neurol. 2000;47(4):521-3. PubMed PMID: 10762166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synphilin-1 is present in Lewy bodies in Parkinson's disease. AU - Wakabayashi,K, AU - Engelender,S, AU - Yoshimoto,M, AU - Tsuji,S, AU - Ross,C A, AU - Takahashi,H, PY - 2000/4/13/pubmed PY - 2000/4/29/medline PY - 2000/4/13/entrez SP - 521 EP - 3 JF - Annals of neurology JO - Ann Neurol VL - 47 IS - 4 N2 - Alpha-synuclein is believed to play an important role in Parkinson's disease (PD). Mutations in the alpha-synuclein gene are responsible for familial forms of PD and alpha-synuclein protein is a major component of Lewy bodies in patients with sporadic PD. Synphilin-1 is a novel protein that we have previously found to associate in vivo with alpha-synuclein. We now show that synphilin-1 is present in Lewy bodies of patients with PD. Our data suggest that synphilin-1 could play a role in Lewy body formation and the pathogenesis of PD. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/10762166/Synphilin_1_is_present_in_Lewy_bodies_in_Parkinson's_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=2000&volume=47&issue=4&spage=521 DB - PRIME DP - Unbound Medicine ER -