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The emergence of salivary cortisol circadian rhythm and its relationship to sleep activity in preterm infants.
Clin Endocrinol (Oxf). 2000 Apr; 52(4):423-6.CE

Abstract

OBJECTIVE

The circadian rhythm of cortisol is established at between 8 and 12 postnatal weeks in term infants. However, there is limited information about the effect of prematurity on this rhythm. We evaluated the emergence of the salivary cortisol circadian rhythm in premature infants and its relationship to the onset of sleep daily rhythm.

DESIGN AND PATIENTS

A longitudinal study of a group of nine premature infants (gestational age 31-34 weeks) was performed. Salivary samples were obtained in the morning and at night at 2, 4, 8, 12, 16, 20 and 24 postnatal weeks and the babies' sleeping periods were recorded by their mothers.

MEASUREMENTS

Cortisol was determined by RIA in 25-microl salivary samples. Two techniques based on assay coefficients of variation were used to characterize the circadian pattern of cortisol.

RESULTS

Five infants (55%) established and maintained their cortisol rhythm at 2 and 8 postnatal weeks. In the remaining four infants the age of appearance was 12 and 16 weeks. This rhythm emerged in the group as a whole between 8 and 12 postnatal weeks. The circadian rhythm of sleep was detected starting from the eighth postnatal week.

CONCLUSIONS

Our data suggest that in this group of premature infants the circadian maturation of the hypothalamic-pituitary-adrenal axis occurred at the same postnatal age as reported for term infants and that there was a parallelism between the appearance of such rhythm and the onset of sleep rhythm.

Authors+Show Affiliations

Department of Paediatrics; Division of Endocrinology, Department of Medicine, Faculty of Medicine of Ribeirão Preto - University of São Paulo, Brazil.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10762284

Citation

Antonini, S R., et al. "The Emergence of Salivary Cortisol Circadian Rhythm and Its Relationship to Sleep Activity in Preterm Infants." Clinical Endocrinology, vol. 52, no. 4, 2000, pp. 423-6.
Antonini SR, Jorge SM, Moreira AC. The emergence of salivary cortisol circadian rhythm and its relationship to sleep activity in preterm infants. Clin Endocrinol (Oxf). 2000;52(4):423-6.
Antonini, S. R., Jorge, S. M., & Moreira, A. C. (2000). The emergence of salivary cortisol circadian rhythm and its relationship to sleep activity in preterm infants. Clinical Endocrinology, 52(4), 423-6.
Antonini SR, Jorge SM, Moreira AC. The Emergence of Salivary Cortisol Circadian Rhythm and Its Relationship to Sleep Activity in Preterm Infants. Clin Endocrinol (Oxf). 2000;52(4):423-6. PubMed PMID: 10762284.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The emergence of salivary cortisol circadian rhythm and its relationship to sleep activity in preterm infants. AU - Antonini,S R, AU - Jorge,S M, AU - Moreira,A C, PY - 2000/4/13/pubmed PY - 2000/6/17/medline PY - 2000/4/13/entrez SP - 423 EP - 6 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 52 IS - 4 N2 - OBJECTIVE: The circadian rhythm of cortisol is established at between 8 and 12 postnatal weeks in term infants. However, there is limited information about the effect of prematurity on this rhythm. We evaluated the emergence of the salivary cortisol circadian rhythm in premature infants and its relationship to the onset of sleep daily rhythm. DESIGN AND PATIENTS: A longitudinal study of a group of nine premature infants (gestational age 31-34 weeks) was performed. Salivary samples were obtained in the morning and at night at 2, 4, 8, 12, 16, 20 and 24 postnatal weeks and the babies' sleeping periods were recorded by their mothers. MEASUREMENTS: Cortisol was determined by RIA in 25-microl salivary samples. Two techniques based on assay coefficients of variation were used to characterize the circadian pattern of cortisol. RESULTS: Five infants (55%) established and maintained their cortisol rhythm at 2 and 8 postnatal weeks. In the remaining four infants the age of appearance was 12 and 16 weeks. This rhythm emerged in the group as a whole between 8 and 12 postnatal weeks. The circadian rhythm of sleep was detected starting from the eighth postnatal week. CONCLUSIONS: Our data suggest that in this group of premature infants the circadian maturation of the hypothalamic-pituitary-adrenal axis occurred at the same postnatal age as reported for term infants and that there was a parallelism between the appearance of such rhythm and the onset of sleep rhythm. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/10762284/The_emergence_of_salivary_cortisol_circadian_rhythm_and_its_relationship_to_sleep_activity_in_preterm_infants_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0300-0664&date=2000&volume=52&issue=4&spage=423 DB - PRIME DP - Unbound Medicine ER -