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Plasma leptin association with body composition and energy expenditure in sickle cell disease.
J Am Coll Nutr 2000; 19(2):228-36JA

Abstract

OBJECTIVE

To examine the association between fasting plasma leptin concentrations and the hypercatabolic state observed in sickle cell disease (SCD).

METHODS

Plasma leptin concentration and resting energy expenditure (REE) were measured in 37 SCD patients (10 men, 12 boys 14 to 18 years-old, seven women, and eight girls 14 to 18 year-old) and in 37 age, gender and fat mass (FM) matched controls. Body composition was measured hydrostatically, REE by whole room-indirect calorimeter, and plasma leptin using an RIA kit.

RESULTS

Plasma leptin concentration and leptin normalized for body fat (ng/dL*kg FM(-1)) were significantly lower in SCD patients than in non-SCD controls (4.00+/-3.23 vs. 9.94+/-14.69, p=0.021 and 0.406+/-0.260 vs. 0.643+/-0.561, p=0.024, respectively). A positive linear association between log plasma leptin and FM was observed in both males and females, adjusting for age and SCD status. The strength of this association was greater in females compared with males (slope=0.699 and 0.382 log ng/mL per 10 kg FM, respectively; p=0.013). SCD patients on average demonstrated a higher REE, adjusting for FFM (p<0.0001). Log plasma leptin and FM were not statistically significant predictors of REE after adjustment for FFM and SCD.

CONCLUSIONS

Once corrected for body composition, mean plasma leptin concentration was significantly lower among female SCD patients than among non-SCD matched controls. Although REE was higher in SCD patients, there is no simple association between leptin and REE in SCD.

Authors+Show Affiliations

Center for Nutrition at Meharry Medical College, Nashville, Tennessee 37208, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10763904

Citation

Buchowski, M S., et al. "Plasma Leptin Association With Body Composition and Energy Expenditure in Sickle Cell Disease." Journal of the American College of Nutrition, vol. 19, no. 2, 2000, pp. 228-36.
Buchowski MS, Simmons LA, Chen KY, et al. Plasma leptin association with body composition and energy expenditure in sickle cell disease. J Am Coll Nutr. 2000;19(2):228-36.
Buchowski, M. S., Simmons, L. A., Chen, K. Y., Flakoll, P. J., Mellen, B. G., & Turner, E. A. (2000). Plasma leptin association with body composition and energy expenditure in sickle cell disease. Journal of the American College of Nutrition, 19(2), pp. 228-36.
Buchowski MS, et al. Plasma Leptin Association With Body Composition and Energy Expenditure in Sickle Cell Disease. J Am Coll Nutr. 2000;19(2):228-36. PubMed PMID: 10763904.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma leptin association with body composition and energy expenditure in sickle cell disease. AU - Buchowski,M S, AU - Simmons,L A, AU - Chen,K Y, AU - Flakoll,P J, AU - Mellen,B G, AU - Turner,E A, PY - 2000/4/14/pubmed PY - 2000/6/3/medline PY - 2000/4/14/entrez SP - 228 EP - 36 JF - Journal of the American College of Nutrition JO - J Am Coll Nutr VL - 19 IS - 2 N2 - OBJECTIVE: To examine the association between fasting plasma leptin concentrations and the hypercatabolic state observed in sickle cell disease (SCD). METHODS: Plasma leptin concentration and resting energy expenditure (REE) were measured in 37 SCD patients (10 men, 12 boys 14 to 18 years-old, seven women, and eight girls 14 to 18 year-old) and in 37 age, gender and fat mass (FM) matched controls. Body composition was measured hydrostatically, REE by whole room-indirect calorimeter, and plasma leptin using an RIA kit. RESULTS: Plasma leptin concentration and leptin normalized for body fat (ng/dL*kg FM(-1)) were significantly lower in SCD patients than in non-SCD controls (4.00+/-3.23 vs. 9.94+/-14.69, p=0.021 and 0.406+/-0.260 vs. 0.643+/-0.561, p=0.024, respectively). A positive linear association between log plasma leptin and FM was observed in both males and females, adjusting for age and SCD status. The strength of this association was greater in females compared with males (slope=0.699 and 0.382 log ng/mL per 10 kg FM, respectively; p=0.013). SCD patients on average demonstrated a higher REE, adjusting for FFM (p<0.0001). Log plasma leptin and FM were not statistically significant predictors of REE after adjustment for FFM and SCD. CONCLUSIONS: Once corrected for body composition, mean plasma leptin concentration was significantly lower among female SCD patients than among non-SCD matched controls. Although REE was higher in SCD patients, there is no simple association between leptin and REE in SCD. SN - 0731-5724 UR - https://www.unboundmedicine.com/medline/citation/10763904/Plasma_leptin_association_with_body_composition_and_energy_expenditure_in_sickle_cell_disease_ L2 - http://www.tandfonline.com/doi/full/10.1080/07315724.2000.10718921 DB - PRIME DP - Unbound Medicine ER -