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Gastro-oesophageal reflux disease in Asia.

Abstract

Gastro-oesophageal reflux disease (GORD) occurs more frequently in Europe and North America than in Asia but its prevalence is now increasing in many Asian countries. Many reasons have been given for the lower prevalence of GORD in Asia. Low dietary fat and genetically determined factors, such as body mass index and maximal acid output, may be important. Other dietary factors appear to be less relevant. Increased intake of carbonated drinks or aggravating medicines may influence the increasing rates of GORD in some Asian countries but no strong evidence links other factors, such as the age of the population, smoking or alcohol consumption, to GORD. The management of GORD in Asia is similar to that in Europe and North America but the lower incidence of severe oesophagitis in Asia may alter the approach slightly. Also, because Asians tend to develop stomach cancer at an earlier age, endoscopy is used routinely at an earlier stage of investigation. Gastro-oesophageal reflux disease is essentially a motility disorder, so short-term management of the disease can usually be achieved using prokinetic agents (or histamine (H2)-receptor antagonists). More severe and recurrent GORD may require proton pump inhibitors (PPI) or a combination of prokinetic agents and PPI. The choice of long-term treatment may be influenced by the relative costs of prokinetic agents and PPI.

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  • Authors+Show Affiliations

    ,

    Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. klgoh@unimed.po.my

    , , , ,

    Source

    MeSH

    Asia
    Gastroesophageal Reflux
    Humans
    Incidence
    Prevalence
    Risk Factors

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    10764021

    Citation

    Goh, K L., et al. "Gastro-oesophageal Reflux Disease in Asia." Journal of Gastroenterology and Hepatology, vol. 15, no. 3, 2000, pp. 230-8.
    Goh KL, Chang CS, Fock KM, et al. Gastro-oesophageal reflux disease in Asia. J Gastroenterol Hepatol. 2000;15(3):230-8.
    Goh, K. L., Chang, C. S., Fock, K. M., Ke, M., Park, H. J., & Lam, S. K. (2000). Gastro-oesophageal reflux disease in Asia. Journal of Gastroenterology and Hepatology, 15(3), pp. 230-8.
    Goh KL, et al. Gastro-oesophageal Reflux Disease in Asia. J Gastroenterol Hepatol. 2000;15(3):230-8. PubMed PMID: 10764021.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Gastro-oesophageal reflux disease in Asia. AU - Goh,K L, AU - Chang,C S, AU - Fock,K M, AU - Ke,M, AU - Park,H J, AU - Lam,S K, PY - 2000/4/14/pubmed PY - 2000/6/8/medline PY - 2000/4/14/entrez SP - 230 EP - 8 JF - Journal of gastroenterology and hepatology JO - J. Gastroenterol. Hepatol. VL - 15 IS - 3 N2 - Gastro-oesophageal reflux disease (GORD) occurs more frequently in Europe and North America than in Asia but its prevalence is now increasing in many Asian countries. Many reasons have been given for the lower prevalence of GORD in Asia. Low dietary fat and genetically determined factors, such as body mass index and maximal acid output, may be important. Other dietary factors appear to be less relevant. Increased intake of carbonated drinks or aggravating medicines may influence the increasing rates of GORD in some Asian countries but no strong evidence links other factors, such as the age of the population, smoking or alcohol consumption, to GORD. The management of GORD in Asia is similar to that in Europe and North America but the lower incidence of severe oesophagitis in Asia may alter the approach slightly. Also, because Asians tend to develop stomach cancer at an earlier age, endoscopy is used routinely at an earlier stage of investigation. Gastro-oesophageal reflux disease is essentially a motility disorder, so short-term management of the disease can usually be achieved using prokinetic agents (or histamine (H2)-receptor antagonists). More severe and recurrent GORD may require proton pump inhibitors (PPI) or a combination of prokinetic agents and PPI. The choice of long-term treatment may be influenced by the relative costs of prokinetic agents and PPI. SN - 0815-9319 UR - https://www.unboundmedicine.com/medline/citation/10764021/Gastro_oesophageal_reflux_disease_in_Asia_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0815-9319&date=2000&volume=15&issue=3&spage=230 DB - PRIME DP - Unbound Medicine ER -