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Behavioral effects of acute and chronic imipramine in the elevated T-maze model of anxiety.
Pharmacol Biochem Behav. 2000 Apr; 65(4):571-6.PB

Abstract

The elevated T-maze is an animal model of anxiety, consisting of three elevated arms: one enclosed and two open. Inhibitory avoidance of the open arms-representing learned fear-has been related to generalized anxiety and the unconditioned escape from one of the open arms to panic. In the present study, we investigated the effects of acute and chronic (21 days) administration of imipramine (5, 10, and 15 mg/kg; IP) in male Wistar rats that have been previously exposed for 30 min to one of the open arms of the T-maze, 24 h before the test. The results show that this preexposure shortens the first escape latency, without changing open-arm avoidance. Under these experimental conditions, chronic imipramine exerted anxiolytic-like effects in the two elevated T-maze tasks; impaired the acquisition of inhibitory avoidance and prolonged escape latency from the open arms. Acute imipramine enhanced both avoidance and escape latencies. Both acute and chronic imipramine decreased locomotor activity measured in a square arena. The obtained results are compatible with the view that inhibitory avoidance and one-way escape in the elevated T-maze reflect different types of fear/anxiety, that may be related to generalized anxiety and panic disorder, respectively.

Authors+Show Affiliations

Laboratory of Psychopharmacology, FFCLRP, University of São Paulo, Ribeirão Preto-SP, Brazil.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10764908

Citation

Teixeira, R C., et al. "Behavioral Effects of Acute and Chronic Imipramine in the Elevated T-maze Model of Anxiety." Pharmacology, Biochemistry, and Behavior, vol. 65, no. 4, 2000, pp. 571-6.
Teixeira RC, Zangrossi H, Graeff FG. Behavioral effects of acute and chronic imipramine in the elevated T-maze model of anxiety. Pharmacol Biochem Behav. 2000;65(4):571-6.
Teixeira, R. C., Zangrossi, H., & Graeff, F. G. (2000). Behavioral effects of acute and chronic imipramine in the elevated T-maze model of anxiety. Pharmacology, Biochemistry, and Behavior, 65(4), 571-6.
Teixeira RC, Zangrossi H, Graeff FG. Behavioral Effects of Acute and Chronic Imipramine in the Elevated T-maze Model of Anxiety. Pharmacol Biochem Behav. 2000;65(4):571-6. PubMed PMID: 10764908.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Behavioral effects of acute and chronic imipramine in the elevated T-maze model of anxiety. AU - Teixeira,R C, AU - Zangrossi,H, AU - Graeff,F G, PY - 2000/4/15/pubmed PY - 2000/5/16/medline PY - 2000/4/15/entrez SP - 571 EP - 6 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 65 IS - 4 N2 - The elevated T-maze is an animal model of anxiety, consisting of three elevated arms: one enclosed and two open. Inhibitory avoidance of the open arms-representing learned fear-has been related to generalized anxiety and the unconditioned escape from one of the open arms to panic. In the present study, we investigated the effects of acute and chronic (21 days) administration of imipramine (5, 10, and 15 mg/kg; IP) in male Wistar rats that have been previously exposed for 30 min to one of the open arms of the T-maze, 24 h before the test. The results show that this preexposure shortens the first escape latency, without changing open-arm avoidance. Under these experimental conditions, chronic imipramine exerted anxiolytic-like effects in the two elevated T-maze tasks; impaired the acquisition of inhibitory avoidance and prolonged escape latency from the open arms. Acute imipramine enhanced both avoidance and escape latencies. Both acute and chronic imipramine decreased locomotor activity measured in a square arena. The obtained results are compatible with the view that inhibitory avoidance and one-way escape in the elevated T-maze reflect different types of fear/anxiety, that may be related to generalized anxiety and panic disorder, respectively. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/10764908/Behavioral_effects_of_acute_and_chronic_imipramine_in_the_elevated_T_maze_model_of_anxiety_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(99)00261-0 DB - PRIME DP - Unbound Medicine ER -