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Use of environmental tobacco smoke constituents as markers for exposure.
Risk Anal. 1999 Jun; 19(3):359-73.RA

Abstract

The 16-City Study analyzed for gas-phase environmental tobacco smoke (ETS) constituents (nicotine, 3-ethenyl pyridine [3-EP], and myosmine) and for particulate-phase constituents (respirable particulate matter [RSP], ultraviolet-absorbing particulate matter [UVPM], fluorescing particulate matter [FPM], scopoletin, and solanesol). In this second of three articles, we discuss the merits of each constituent as a marker for ETS and report pair-wise comparisons of the markers. Neither nicotine nor UVPM were good predictors for RSP. However, nicotine and UVPM were good qualitative predictors of each other. Nicotine was correlated with other gas-phase constituents. Comparisons between UVPM and other particulate-phase constituents were performed. Its relation with FPM was excellent, with UVPM approximately 1 1/2 times FPM. The correlation between UVPM and solanesol was good, but the relationship between the two was not linear. The relation between UVPM and scopoletin was not good, largely because of noise in the scopoletin measures around its limit of detection. We considered the relation between nicotine and saliva continine, a metabolite of nicotine. The two were highly correlated on the group level. That is, for each cell (smoking home and work, smoking home but nonsmoking work, and so forth), there was high correlation between average continine and 24-hour time-weighted average (TWA) nicotine concentrations. However, on the individual level, the correlations, although significant, were not biologically meaningful. A consideration of cotinine and nicotine or 3-EP on a subset of the study whose only exposure to ETS was exclusively at work or exclusively at home showed that home exposure was a more important source of ETS than work exposure.

Authors+Show Affiliations

Johns Hopkins University, Department of Mathematical Sciences, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10765410

Citation

LaKind, J S., et al. "Use of Environmental Tobacco Smoke Constituents as Markers for Exposure." Risk Analysis : an Official Publication of the Society for Risk Analysis, vol. 19, no. 3, 1999, pp. 359-73.
LaKind JS, Jenkins RA, Naiman DQ, et al. Use of environmental tobacco smoke constituents as markers for exposure. Risk Anal. 1999;19(3):359-73.
LaKind, J. S., Jenkins, R. A., Naiman, D. Q., Ginevan, M. E., Graves, C. G., & Tardiff, R. G. (1999). Use of environmental tobacco smoke constituents as markers for exposure. Risk Analysis : an Official Publication of the Society for Risk Analysis, 19(3), 359-73.
LaKind JS, et al. Use of Environmental Tobacco Smoke Constituents as Markers for Exposure. Risk Anal. 1999;19(3):359-73. PubMed PMID: 10765410.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of environmental tobacco smoke constituents as markers for exposure. AU - LaKind,J S, AU - Jenkins,R A, AU - Naiman,D Q, AU - Ginevan,M E, AU - Graves,C G, AU - Tardiff,R G, PY - 2000/4/15/pubmed PY - 2000/4/15/medline PY - 2000/4/15/entrez SP - 359 EP - 73 JF - Risk analysis : an official publication of the Society for Risk Analysis JO - Risk Anal VL - 19 IS - 3 N2 - The 16-City Study analyzed for gas-phase environmental tobacco smoke (ETS) constituents (nicotine, 3-ethenyl pyridine [3-EP], and myosmine) and for particulate-phase constituents (respirable particulate matter [RSP], ultraviolet-absorbing particulate matter [UVPM], fluorescing particulate matter [FPM], scopoletin, and solanesol). In this second of three articles, we discuss the merits of each constituent as a marker for ETS and report pair-wise comparisons of the markers. Neither nicotine nor UVPM were good predictors for RSP. However, nicotine and UVPM were good qualitative predictors of each other. Nicotine was correlated with other gas-phase constituents. Comparisons between UVPM and other particulate-phase constituents were performed. Its relation with FPM was excellent, with UVPM approximately 1 1/2 times FPM. The correlation between UVPM and solanesol was good, but the relationship between the two was not linear. The relation between UVPM and scopoletin was not good, largely because of noise in the scopoletin measures around its limit of detection. We considered the relation between nicotine and saliva continine, a metabolite of nicotine. The two were highly correlated on the group level. That is, for each cell (smoking home and work, smoking home but nonsmoking work, and so forth), there was high correlation between average continine and 24-hour time-weighted average (TWA) nicotine concentrations. However, on the individual level, the correlations, although significant, were not biologically meaningful. A consideration of cotinine and nicotine or 3-EP on a subset of the study whose only exposure to ETS was exclusively at work or exclusively at home showed that home exposure was a more important source of ETS than work exposure. SN - 0272-4332 UR - https://www.unboundmedicine.com/medline/citation/10765410/Use_of_environmental_tobacco_smoke_constituents_as_markers_for_exposure_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0272-4332&date=1999&volume=19&issue=3&spage=359 DB - PRIME DP - Unbound Medicine ER -