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Genetic testing and surgical decision making in hereditary colorectal cancer.
Int J Colorectal Dis 2000; 15(1):21-8IJ

Abstract

Hereditary colorectal cancer results from specific genetic alterations. The causative genes for familial adenomatous polyposis, juvenile polyposis, Peutz-Jeghers syndrome, and hereditary nonpolyposis colorectal cancer have been cloned and characterized within the past decade. Genetic testing has therefore become more widely used to confirm the clinical diagnosis of each of those syndromes, to provide adequate surveillance, to allow screening of at-risk family members, and to help the surgeon in surgical decision making. The aim of this review is to analyze the importance of genetic testing in view of the clinical and surgical management of those gene-carriers individuals, and to discuss how should the surgeon integrate genetic testing in the evaluation of such patients.

Authors+Show Affiliations

Clinique de Chirurgie Digestive, Geneva University Hospital, Switzerland. Claudio.Soravia@hcuge.chNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10766087

Citation

Soravia, C, et al. "Genetic Testing and Surgical Decision Making in Hereditary Colorectal Cancer." International Journal of Colorectal Disease, vol. 15, no. 1, 2000, pp. 21-8.
Soravia C, Berk T, Cohen Z. Genetic testing and surgical decision making in hereditary colorectal cancer. Int J Colorectal Dis. 2000;15(1):21-8.
Soravia, C., Berk, T., & Cohen, Z. (2000). Genetic testing and surgical decision making in hereditary colorectal cancer. International Journal of Colorectal Disease, 15(1), pp. 21-8.
Soravia C, Berk T, Cohen Z. Genetic Testing and Surgical Decision Making in Hereditary Colorectal Cancer. Int J Colorectal Dis. 2000;15(1):21-8. PubMed PMID: 10766087.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic testing and surgical decision making in hereditary colorectal cancer. AU - Soravia,C, AU - Berk,T, AU - Cohen,Z, PY - 2000/4/15/pubmed PY - 2000/6/8/medline PY - 2000/4/15/entrez SP - 21 EP - 8 JF - International journal of colorectal disease JO - Int J Colorectal Dis VL - 15 IS - 1 N2 - Hereditary colorectal cancer results from specific genetic alterations. The causative genes for familial adenomatous polyposis, juvenile polyposis, Peutz-Jeghers syndrome, and hereditary nonpolyposis colorectal cancer have been cloned and characterized within the past decade. Genetic testing has therefore become more widely used to confirm the clinical diagnosis of each of those syndromes, to provide adequate surveillance, to allow screening of at-risk family members, and to help the surgeon in surgical decision making. The aim of this review is to analyze the importance of genetic testing in view of the clinical and surgical management of those gene-carriers individuals, and to discuss how should the surgeon integrate genetic testing in the evaluation of such patients. SN - 0179-1958 UR - https://www.unboundmedicine.com/medline/citation/10766087/Genetic_testing_and_surgical_decision_making_in_hereditary_colorectal_cancer_ L2 - http://www.diseaseinfosearch.org/result/3345 DB - PRIME DP - Unbound Medicine ER -